Research Progress on Near-infrared Persistent Luminescence Nanoparticles in Tumor Diagnosis and Treatment

doi:10.15541/jim20260020

Abstract

Abstract: Near-infrared persistent luminescence nanoparticles (NIR-PLNPs) have become a focal point in the field of cancer theranostics due to their unique delayed luminescence properties, which effectively avoid biological autofluorescence interference and significantly enhance imaging signal-to-noise ratio and tissue penetration depth. Through material design and surface functionalization, NIR-PLNPs can achieve tumor-specific recognition and serve as multifunctional nanoplatforms for high-contrast imaging-guided surgical resection and precise synergistic therapy. In contrast to previous reviews, this article particularly emphasizes recent advances in imaging-guided precision tumor resection, stimuli-responsive drug delivery, photodynamic therapy and photothermal therapy, analyzes key bottlenecks in clinical translation, such as biosafety and optimization of persistent luminescence properties, and propose future research directions, aiming to provide a systematic reference for the clinical advancement.

Key words: near-infrared persistent luminescence, nanoparticle, tumor diagnosis, tumor treatment, review

CLC Number:

TB34

ZHU Yaqi, LI Chao, CHEN Tianci, LIU Zhiyan, CHEN Yifei, WANG Haoliang. Research Progress on Near-infrared Persistent Luminescence Nanoparticles in Tumor Diagnosis and Treatment[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20260020.

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