Abstract: Bioactive glasses (BG) are an important class of amorphous inorganic biomaterials, which have been clinically used in hard tissue repair for many years, exhibiting unique tissue repair activity. Recent studies have found that BG also shows effective repair activity in soft tissue, demonstrating significant application potential. Compared with traditional BG, micro-nano bioactive glass (MNBG) has a unique micro-nano structure, which not only retains its excellent chemical composition but also has a larger specific surface area and higher reactivity. These special structures and properties enable MNBG to exhibit significant application potential in promoting vascularization and skin repair and regeneration. This work focuses on the research progress of MNBG in regulating vascularization and skin regeneration. The main content of the paper includes the ability of MNBG to promote vascularization, regulate immune cell function, and its antioxidant, anti-inflammatory, and antibacterial properties. These characteristics enable MNBG to effectively stimulate blood vessel formation, reduce inflammation, and inhibit bacterial infection, thus promoting wound healing and tissue repair. This paper summarizes the key research on the role of MNBG in vascularization and skin wound repair and offers recommendations on the existing issues and future research directions in the application of MNBG in skin wound repair. The aim is to promote the application transformation of MNBG in the field of skin repair.

Key words: micro-nano bioactive glass, vascularization, skin regeneration, bioactive materials, review