Inorganic Biomaterials on Regulating Neural Cell and Innervated Tissue Regeneration: A Review

doi:10.15541/jim20250001

Abstract

Abstract: In regarding to the crucial role of nerves in tissue regeneration, developing tissue engineering scaffolds with neural-activities have attracted more attentions. Recently, inorganic biomaterials have been extensively used in regulating neural cell functions and innervated tissue regeneration due to their advantages of highly controllable chemical compositions, micro/nano topographical structures, and excellent physicochemical properties. This review firstly introduces the typical used inorganic biomaterials, including bioceramics and electroactive materials, and then elaborates their biological effects of enhancing neural cells viabilities and functions through modulating cell behaviors, regulating immune microenvironment, and constructing electroactive microenvironment. Subsequently, recent progress of inorganic biomaterials on various innervated tissue regeneration such as spinal cord, peripheral nerves, skin, skeletal muscles, and cavernous tissues was summarized. Finally, the current challenges and future perspectives of inorganic biomaterials in innervated tissue regeneration were discussed.

Key words: inorganic biomaterials, bioceramics, electroactive materials, tissue regeneration, innervation, review

CLC Number:

TQ174

ZHANG Hongjian, ZHAO Ziyi, WU Chengtie. Inorganic Biomaterials on Regulating Neural Cell and Innervated Tissue Regeneration: A Review[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250001.

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