近红外长余辉发光纳米探针在肿瘤诊疗中的研究进展

doi:10.15541/jim20260020

摘要/Abstract

摘要： 近红外长余辉发光纳米探针(Near-infrared Persistent Luminescence Nanoparticles, NIR-PLNPs)凭借独特的延迟发光特性,可有效避免生物自荧光干扰,显著提升成像信噪比与组织穿透深度,成为肿瘤诊疗一体化领域的研究热点。通过材料设计与表面功能化,可特异性识别肿瘤,同时构建多功能纳米平台,实现高对比度成像引导手术切除术,以及对肿瘤的精准协同治疗。本文系统梳理了NIR-PLNPs的可控合成策略及成像应用。相比于以往综述,本文重点针对其在肿瘤成像引导的精准手术切除、智能药物控释、光动力治疗及光热治疗等领域的最新研究进展进行归纳讨论,提出了当前临床转化面临的生物安全性、余辉性能优化等关键瓶颈问题,并展望了未来的发展方向,旨在为NIR-PLNPs的临床转化提供系统性参考。

关键词: 近红外长余辉发光, 纳米探针, 肿瘤诊断, 肿瘤治疗, 综述

Abstract: Near-infrared persistent luminescence nanoparticles (NIR-PLNPs) have become a focal point in the field of cancer theranostics due to their unique delayed luminescence properties, which effectively avoid biological autofluorescence interference and significantly enhance imaging signal-to-noise ratio and tissue penetration depth. Through material design and surface functionalization, NIR-PLNPs can achieve tumor-specific recognition and serve as multifunctional nanoplatforms for high-contrast imaging-guided surgical resection and precise synergistic therapy. In contrast to previous reviews, this article particularly emphasizes recent advances in imaging-guided precision tumor resection, stimuli-responsive drug delivery, photodynamic therapy and photothermal therapy, analyzes key bottlenecks in clinical translation, such as biosafety and optimization of persistent luminescence properties, and propose future research directions, aiming to provide a systematic reference for the clinical advancement.

Key words: near-infrared persistent luminescence, nanoparticle, tumor diagnosis, tumor treatment, review

中图分类号:

TB34

朱雅琪, 李超, 陈天赐, 刘芷言, 陈怡菲, 王浩良. 近红外长余辉发光纳米探针在肿瘤诊疗中的研究进展[J]. 无机材料学报, DOI: 10.15541/jim20260020.

ZHU Yaqi, LI Chao, CHEN Tianci, LIU Zhiyan, CHEN Yifei, WANG Haoliang. Research Progress on Near-infrared Persistent Luminescence Nanoparticles in Tumor Diagnosis and Treatment[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20260020.

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