微纳米生物活性玻璃：功能化设计与血管化皮肤再生

doi:10.15541/jim20240541

摘要/Abstract

摘要： 生物活性玻璃（BG）材料是一类重要的非晶态无机医用材料, 在硬组织修复领域临床应用多年, 表现出独特的组织修复活性。近年来研究发现, 生物活性玻璃在促进软组织修复方面也表现出有效的修复活性, 具有重要的应用价值。与传统的 BG 相比, 微纳米生物活性玻璃（MNBG）具有独特的微纳米结构, 不仅保留了其优良的化学组成, 而且具有更大的比表面积和更高的反应活性, 在促进血管化皮肤修复再生方面表现出重要的应用潜力。本文将重点讨论 MNBG 在调控血管化及皮肤再生方面的研究进展。本文主要内容包括 MBGN 促进血管化的能力, 调控免疫细胞的功能, 以及其抗氧化、抗炎和抗菌性能, 这些特性使得 MNBG 能够有效刺激血管形成, 同时降低炎症反应, 抑制细菌感染, 从而促进伤口愈合和组织修复。本文重点总结了 MNBG 在皮肤创面血管化和修复方面的重要研究进展, 并对 MNBG 目前皮肤创面修复应用中存在的问题和未来的研究方向提出相应的建议, 以期推动 MNBG 在皮肤修复领域中的应用转化。

关键词: 微纳生物活性玻璃, 血管化, 皮肤再生, 生物活性材料, 综述

Abstract: Bioactive glasses (BG) are an important class of amorphous inorganic biomaterials, which have been clinically used in hard tissue repair for many years, exhibiting unique tissue repair activity. Recent studies have found that BG also shows effective repair activity in soft tissue, demonstrating significant application potential. Compared with traditional BG, micro-nano bioactive glass (MNBG) has a unique micro-nano structure, which not only retains its excellent chemical composition but also has a larger specific surface area and higher reactivity. These special structures and properties enable MNBG to exhibit significant application potential in promoting vascularization and skin repair and regeneration. This work focuses on the research progress of MNBG in regulating vascularization and skin regeneration. The main content of the paper includes the ability of MNBG to promote vascularization, regulate immune cell function, and its antioxidant, anti-inflammatory, and antibacterial properties. These characteristics enable MNBG to effectively stimulate blood vessel formation, reduce inflammation, and inhibit bacterial infection, thus promoting wound healing and tissue repair. This paper summarizes the key research on the role of MNBG in vascularization and skin wound repair and offers recommendations on the existing issues and future research directions in the application of MNBG in skin wound repair. The aim is to promote the application transformation of MNBG in the field of skin repair.

Key words: micro-nano bioactive glass, vascularization, skin regeneration, bioactive materials, review

中图分类号:

TQ171

艾敏慧, 雷波. 微纳米生物活性玻璃：功能化设计与血管化皮肤再生[J]. 无机材料学报, DOI: 10.15541/jim20240541.

AI Minhui, LEI Bo. Micro-nanoscale Bioactive Glass: Functionalized Design and Angiogenic Skin Regeneration[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20240541.

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