无机生物材料调控神经细胞功能及神经化组织再生的研究进展

doi:10.15541/jim20250001

摘要/Abstract

摘要： 基于神经在组织再生中的关键作用,开发具有神经诱导活性的组织工程支架引起了研究者们的广泛关注。近年来,无机生物材料因具有高度可控的化学组成、微/纳拓扑结构及优异的理化性能,在调控神经细胞功能及神经化组织再生中得到广泛应用。本文首先介绍了常用无机生物材料,主要包括生物陶瓷材料和电活性材料,并阐述了无机生物材料通过调控细胞行为、调节免疫微环境和构建电活性微环境等途径对神经细胞活性及生物学功能的增强作用,重点阐述了无机生物材料在脊髓、周围神经、皮肤、骨骼肌、海绵体等组织神经化再生中的最新研究进展,最后讨论了无机生物材料在调控神经细胞活性及神经化组织再生中存在的难题及未来发展前景。

关键词: 无机生物材料, 生物陶瓷, 电活性材料, 组织再生, 神经化, 综述

Abstract: In regarding to the crucial role of nerves in tissue regeneration, developing tissue engineering scaffolds with neural-activities have attracted more attentions. Recently, inorganic biomaterials have been extensively used in regulating neural cell functions and innervated tissue regeneration due to their advantages of highly controllable chemical compositions, micro/nano topographical structures, and excellent physicochemical properties. This review firstly introduces the typical used inorganic biomaterials, including bioceramics and electroactive materials, and then elaborates their biological effects of enhancing neural cells viabilities and functions through modulating cell behaviors, regulating immune microenvironment, and constructing electroactive microenvironment. Subsequently, recent progress of inorganic biomaterials on various innervated tissue regeneration such as spinal cord, peripheral nerves, skin, skeletal muscles, and cavernous tissues was summarized. Finally, the current challenges and future perspectives of inorganic biomaterials in innervated tissue regeneration were discussed.

Key words: inorganic biomaterials, bioceramics, electroactive materials, tissue regeneration, innervation, review

中图分类号:

TQ174

张洪健, 赵梓壹, 吴成铁. 无机生物材料调控神经细胞功能及神经化组织再生的研究进展[J]. 无机材料学报, DOI: 10.15541/jim20250001.

ZHANG Hongjian, ZHAO Ziyi, WU Chengtie. Inorganic Biomaterials on Regulating Neural Cell and Innervated Tissue Regeneration: A Review[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250001.

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