二维无机材料调控病损皮肤组织再生的研究进展

doi:10.15541/jim20240508

摘要/Abstract

摘要： 二维无机材料作为一类具有单原子层或几层原子层的无机超薄纳米片,呈现出高比表面积、高导电性和/或高光热转换效率等特点。这些独特的理化特性赋予其促凝血、抗菌、抗炎和抗氧化的生物学效应。近年来,鉴于降解和代谢问题,该类材料被探索应用于调控病损皮肤组织,如全层皮肤缺损、烧烫伤及糖尿病创面等,展现出加速伤口愈合、减轻感染及改善炎症微环境的显著效果。本文围绕二维无机材料的特有结构和生物效应,系统性阐述其在伤口愈合中的应用及相关作用机制,并展望了目前二维无机材料在皮肤修复领域所面临的挑战和前景。

关键词: 无机材料, 二维纳米材料, 皮肤修复, 微环境调节, 综述

Abstract: Two-dimensional（2D）inorganic materials , as a class of inorganic ultrathin nanosheets with single or several atomic layers, exhibit high specific surface area, electrical conductivity and/or photothermal conversion efficiency. These unique physicochemical properties confer procoagulant, antibacterial, anti-inflammatory, and antioxidant biological effects. In recent years, in view of degradation and metabolism issues, these materials have been explored for the modulation of diseased skin tissues, such as full-thickness wounds, burns and diabetic wounds, demonstrating remarkable effects in accelerating wound healing, alleviating infections and improving the inflammatory microenvironment. This manuscript focuses on the unique structure and biological effects of 2D inorganic materials, systematically describes their applications in wound healing and related mechanisms, and looks forward to current challenges and prospects of the 2D inorganic materials in the field of skin repair.

Key words: inorganic material, two-dimensional nanomaterial, skin repair, microenvironmental regulation, review

中图分类号:

肖晓琳, 王玉祥, 谷佩洋, 朱圳荣, 孙勇. 二维无机材料调控病损皮肤组织再生的研究进展[J]. 无机材料学报, DOI: 10.15541/jim20240508.

XIAO Xiaolin, WANG Yuxiang, GU Peiyang, ZHU Zhenrong, SUN Yong. Advances in Regulation of Damaged Skin Regeneration by Two-dimensional Inorganic Materials[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20240508.

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