无机材料学报 ›› 2026, Vol. 41 ›› Issue (4): 432-444.DOI: 10.15541/jim20250144 CSTR: 32189.14.10.15541/jim20250144
李璇1,2(
), 叶奎材1, 冯佳音1, 邱家军3, 钱文昊1(), 邢敏1()
收稿日期:2025-04-07
修回日期:2025-06-05
出版日期:2025-06-27
网络出版日期:2025-06-27
通讯作者:
邢 敏, 副研究员. E-mail: xingmin0821@126.com;作者简介:李 璇(2000-), 女, 硕士研究生. E-mail: 2233092@mail.dhu.edu.cn
基金资助:
LI Xuan1,2(), YE Kuicai1, FENG Jiayin1, QIU Jiajun3, QIAN Wenhao1(), XING Min1()
Received:2025-04-07
Revised:2025-06-05
Published:2025-06-27
Online:2025-06-27
Contact:
XING Min, associate professor. E-mail: xingmin0821@126.com;About author:LI Xuan (2000-), female, Master candidate. E-mail: 2233092@mail.dhu.edu.cn
Supported by:摘要：
钛及钛合金因其优异的力学性能、耐腐蚀性和生物相容性, 被广泛用作牙种植体材料。然而, 钛基牙种植体在临床使用中软组织封闭不佳, 易使细菌侵入诱发种植体周炎, 导致种植体植入手术失败。因此, 为提升钛基牙种植体的软组织封闭性能, 降低种植体植入手术的失败率, 国内外学者开展了持续、深入的研究。本文综述了近年来钛基牙种植体软组织封闭表面改性研究系列进展, 着重介绍了钛表面化学组分调控和微纳结构构建方法, 指出了当前研究面临的挑战以及未来发展趋势, 以期为该领域的进一步研究提供参考。
中图分类号:
李璇, 叶奎材, 冯佳音, 邱家军, 钱文昊, 邢敏. 钛基牙种植体表面改性促进软组织封闭的研究进展[J]. 无机材料学报, 2026, 41(4): 432-444.
LI Xuan, YE Kuicai, FENG Jiayin, QIU Jiajun, QIAN Wenhao, XING Min. Surface Modification of Titanium-based Dental Implants for Soft Tissue Sealing: A Review[J]. Journal of Inorganic Materials, 2026, 41(4): 432-444.
图1 钛基牙种植体口腔微环境、软组织生理学及各种表面改性方法[7]
Fig. 1 Oral microenvironment and soft tissue around titanium-based dental implants along with various surface modification techniques[7]
图2 种植体周围组织结构示意图[6]
Fig. 2 Schematic diagram of peri-implant tissue structure[6]
图3 采用层层自组装法的软组织封闭及抗菌效果[27-28,30]
Fig. 3 Soft tissue sealing and antibacterial effects promoted by layer-by-layer self-assembly method[27-28,30] (a) Schemetic diagram of TA-Ce-Mino coating design and SEM images showing topography of the coating[27]; (b) Hemidesmosome detected by TEM[28]; (c) Immunohistochemistry staining results of expression of the hemidesmosome related protein laminin 5α3[28]; (d) Antibacterial efficacy of Ti-PEMs samples against P. gingivalis[30]
图4 电化学沉积法制备钛基涂层示意图及该涂层对细胞迁移的作用[34]
Fig. 4 Schematic diagram of titanium-based coating prepared by electrochemical deposition and its effect on promoting cell migration[34] (a) Electrochemical deposition model for modification of Col-Ι on Ti[34]; (b1-b3) SEM images of L929 fibroblast cell reseeding on (b1) untreated Ti, (b2) TiO2 porous surface and (b3) coated Ti/Col-Ι (scale bar: 10 and 2 μm, respectively)[34]
图5 等离子喷涂法制备钛基涂层示意图[38]
Fig. 5 Schematic diagram of titanium-based coating prepared by plasma spraying[38]
图6 采用阳极氧化法的软组织封闭及抗菌效果[75-76,78 -79]
Fig. 6 Soft tissue sealing and antibacterial effects promoted by anodic oxidation method [75-76,78 -79] (a) Soft tissue sealing efficacy promoted by TNT-30, TNT-40 and TNT-50 (scale bar: 100 μm)[75]; (b) Soft tissue sealing efficacy promoted by Fe-NC@TNT[76]; (c) Thirty-day cumulative average quantity of doxycycline released under pH 5.4, 6.4 and 7.4[78]; (d) Antibacterial activity of TNTs-Van@ZnO-FA under different pH against S. aureus[79]
图7 微弧氧化法制备钛基涂层示意图及其软组织封闭效果[82-84]
Fig. 7 Titanium-based coating prepared by micro-arc oxidation and its effect on promoting soft tissue sealing[82-84] (a) Schematic illustration of titanium-based coating fabrication via micro-arc oxidation and characteristic surface morphology[82-83]; (b) Schematic diagram of CCN2@MSNs-Ti prepared by micro-arc oxidation[84]; (c) Effects of S-Ti, MAO-Ti, and CCN2@MSNs-Ti on HDFs migration (scale bar: 50 (left) and 10 (right) μm, respectively)[84]; (d) Fluorescence staining of HGFs for incubation on Ti and MAO treated surfaces without UV treatment (UV−) and with UV treatment (UV+)[82]
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