钛基牙种植体表面改性促进软组织封闭的研究进展

doi:10.15541/jim20250144

无机材料学报

• •

钛基牙种植体表面改性促进软组织封闭的研究进展

李璇^1,2, 叶奎材¹, 冯佳音¹, 邱家军³, 钱文昊¹, 邢敏¹

1.上海市徐汇区口腔医院口腔生物材料与组织再生实验室,上海 200032;
2.东华大学生物与医学工程学院,上海 201620;
3.中国科学院上海硅酸盐研究所生物材料与组织工程研究中心,上海 200050

收稿日期:2025-04-07 修回日期:2025-06-05
通讯作者: 邢敏, 副研究员. E-mail: xingmin0821@126.com;钱文昊, 主任医师. E-mail: pingyanlaoto@163.com
作者简介:李璇 (2000-), 女, 硕士研究生. E-mail: 2233092@mail.dhu.edu.cn
基金资助:
国家自然科学基金(52272283); 上海市徐汇区牙病防治所医学科研项目(SHXYFJX202501)

Surface Modification of Titanium-based Dental Implants for Soft Tissue Sealing: A Review

LI Xuan^1,2, YE Kuicai¹, FENG Jiayin¹, QIU Jiajun³, QIAN Wenhao¹, XING Min¹

1. Laboratory of Dental Biomaterials and Tissue Regeneration, Shanghai Xuhui District Stomatological Hospital, Shanghai 200032, China;
2. College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China;
3. Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

Received:2025-04-07 Revised:2025-06-05
Contact: XING Min, associate professor. E-mail: xingmin0821@126.com; QIAN Wenhao, chief physician. E-mail: pingyanlaoto@163.com
About author:LI Xuan (2000–), female, Master candidate. E-mail: 2233092@mail.dhu.edu.cn
Supported by:
National Natural Science Foundation of China (52272283); Medical Research Project of Shanghai Xuhui District Dental Center (SHXYFJX202501)

摘要/Abstract

摘要： 钛及钛合金因其优异的力学性能、耐腐蚀性和生物相容性,被广泛用作牙种植体材料。然而钛基牙种植体在临床使用中因软组织封闭不佳,细菌容易侵入诱发种植体周炎,导致种植体植入手术失败。因此,为钛基牙种植体赋予软组织封闭能力以有效降低种植体植入手术的失败率,国内外研究者对此作了持续、深入的研究。本文综述了近年来钛基牙种植体软组织封闭表面改性研究系列进展,着重介绍了钛表面化学组分调控和微纳结构构建方法,指出了钛基牙种植体软组织封闭表面改性研究中尚存的挑战以及未来发展趋势,以期为钛基牙种植体软组织封闭研究提供参考。

关键词: 钛, 种植体, 软组织封闭, 抗菌, 表面改性, 综述

Abstract: Titanium and its alloys are widely used as dental implant materials due to their excellent mechanical property, corrosion resistance and biocompatibility. However, in clinical applications, titanium-based dental implants often suffer from poor soft tissue sealing, allowing bacteria to invade and induce peri-implantitis, leading to final implant failure. To address these issues and reduce the failure rate of implant surgery effectively, researchers worldwide have conducted extensive and in-depth studies. This article reviews recent advancements in surface modification strategies for improving soft tissue sealing on titanium-based dental implants, with the focus on methods for regulating surface chemical composition and constructing micro-nano structures. Additionally, it highlights the existing challenges and future trends in this field, aiming to provide valuable insights for further research on soft tissue sealing of titanium-based dental implants.

Key words: titanium, implant, soft tissue sealing, antibacterial, surface modification, review

中图分类号:

李璇, 叶奎材, 冯佳音, 邱家军, 钱文昊, 邢敏. 钛基牙种植体表面改性促进软组织封闭的研究进展[J]. 无机材料学报, DOI: 10.15541/jim20250144.

LI Xuan, YE Kuicai, FENG Jiayin, QIU Jiajun, QIAN Wenhao, XING Min. Surface Modification of Titanium-based Dental Implants for Soft Tissue Sealing: A Review[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250144.

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钛基牙种植体表面改性促进软组织封闭的研究进展

Surface Modification of Titanium-based Dental Implants for Soft Tissue Sealing: A Review

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