Advances in Silicate Bioceramic/Bioglass for Wound Healing: Effects, Mechanisms and Application Ways

doi:10.15541/jim20250014

Abstract

Abstract:

Extensive skin trauma represents one of the most challenging issues in global public health, and its repair and treatment impose a huge economic burden on healthcare systems. Therefore, there is an urgent need to develop an efficient wound dressing that can promote skin regeneration at the wound site. In recent years, silicate bioceramics/bioglasses have received widespread attention and application in the field of wound healing due to their multiple advantages, including promoting angiogenesis, stimulating collagen deposition, and anti-infection properties. This paper provides a concise overview of the mechanisms through which silicate-based bioceramics/ bioglasses contribute to skin regeneration, analyzes their integration with emerging technologies and their applications in wound healing, and summarizes the advantages and limitations of these materials. This review aims to inform and guide the future clinical application of silicate-based bioceramics/bioglasses in wound healing.

Key words: silicate, bioceramic/bioglass, active ion, wound healing, review

CLC Number:

TQ171

WANG Yutong, CHANG Jiang, XU He, WU Chengtie. Advances in Silicate Bioceramic/Bioglass for Wound Healing: Effects, Mechanisms and Application Ways[J]. Journal of Inorganic Materials, 2025, 40(8): 911-920.

Figures/Tables 6

Fig. 1 Mechanisms and applications of silicate bioceramics/ bioglasses in promoting skin regeneration

Fig. 2 Schematic illustration of the probable regulatory mechanism to macrophage inflammation responses by bioactive silicate ceramics[27] (Reprinted with permission; Copyright (2018) Elsevier Ltd.)

Fig. 3 Fiber scaffolds with surface modification of CaCuSi4O10 for early photothermal therapy and subsequent skin tissue reconstruction[39] (Reprinted with permission; Copyright (2019) Elsevier Ltd.)

Fig. 4 Design strategy for fabrication of multifunctional sandwich-like NF-HG[62] DA: dopamine; TH: tetracycline hydrochloride; NF-HG: nanofibers/hydrogel (Reprinted with permission; Copyright (2020) Elsevier Ltd.)

Fig. 5 Preparation and mechanism of magnesium silicate sprays for burn-wound repair and appendage regeneration[66] TUBB3: Tubulin beta-3; GAP43: Growth-associated protein 43; α-SMA: α-smooth muscle actin (Reprinted with permission; Copyright (2023) Elsevier Ltd.)

Fig. 6 Schematic illustration of silicate composite electrospun scaffolds[69] (Reprinted with permission; Copyright (2019) American Chemical Society)

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