Advances in Silicate Bioceramic/Glass for Wound Healing: Effects, Mechanisms and Application Ways

doi:10.15541/jim20250014

Abstract

Abstract: Extensive skin trauma represents one of the most challenging issues in global public health, and its repair and treatment impose a huge economic burden on healthcare systems. Therefore, there is an urgent need to develop an efficient wound dressing that can promote skin regeneration at the wound site. In recent years, silicate bioceramics/bioglass have received widespread attention and application in the field of wound healing due to their multiple advantages, including promoting angiogenesis, stimulating collagen deposition, and anti-infection properties. This paper provides a concise overview of the mechanisms through which silicate-based bioceramics and bioactive glass contribute to skin regeneration, analyzes their integration with emerging technologies and their applications in wound healing, and summarizes advantages and limitations of these materials. This review aims to inform and guide the future clinical application of silicate-based bioceramics and bioactive glass in wound healing.

Key words: silicate, bioceramic/bioglass, active ion, wound healing, review

CLC Number:

TQ171

WANG Yutong, CHANG Jiang, XU He, WU Chengtie. Advances in Silicate Bioceramic/Glass for Wound Healing: Effects, Mechanisms and Application Ways[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250014.

References

[1] SANJARNIA P, PICCHIO M L, POLEGRE SOLIS A N, et al. Bringing innovative wound care polymer materials to the market: challenges, developments, and new trends. Advanced Drug Delivery Reviews, 2024, 207: 115217.
[2] RAZIYEVA K, KIM Y, ZHARKINBEKOV Z, et al. Immunology of acute and chronic wound healing. Biomolecules, 2021, 11(5): 700.
[3] SEN C K.Human wounds and its burden: an updated compendium of estimates.Advances in Wound Care, 2019, 8(2): 39.
[4] WU M, GAO B B, WEI X B.Recent advances in Raman spectroscopy for skin diagnosis.Journal of Innovative Optical Health Sciences, 2023, 16(03): 2330003.
[5] SHANG F, LU Y H, GAO J, et al. Comparison of therapeutic effects between artificial dermis combined with autologous split-thickness skin grafting and autologous intermediate-thickness skin grafting alone in severely burned patients: a prospective randomised study. International Wound Journal, 2021, 18(1): 24.
[6] FAN C, XU Q, HAO R Q, et al. Multi-functional wound dressings based on silicate bioactive materials. Biomaterials, 2022, 287: 121652.
[7] WANG L L, ZHAO R, LI J Y, et al. Pharmacological activation of cannabinoid 2 receptor attenuates inflammation, fibrogenesis, and promotes re-epithelialization during skin wound healing. European Journal of Pharmacology, 2016, 786: 128.
[8] YU Q Q, CHANG J, WU C T.Silicate bioceramics: from soft tissue regeneration to tumor therapy.Journal of Materials Chemistry B, 2019, 7(36): 5449.
[9] LI H Y, CHANG J.Stimulation of proangiogenesis by calcium silicate bioactive ceramic.Acta Biomaterialia, 2013, 9(2): 5379.
[10] LI H, CHANG J.Bioactive silicate materials stimulate angiogenesis in fibroblast and endothelial cell co-culture system through paracrine effect.Acta Biomaterialia, 2013, 9(6): 6981.
[11] ZHAI W Y, LU H X, CHEN L, et al. Silicate bioceramics induce angiogenesis during bone regeneration. Acta Biomaterialia, 2012, 8(1): 341.
[12] LI B M, HU W Z, MA K, et al. Are hair follicle stem cells promising candidates for wound healing? Expert Opinion on Biological Therapy, 2019, 19(2): 119.
[13] WU Y K, CHENG N C, CHENG C M.Biofilms in chronic wounds: pathogenesis and diagnosis.Trends in Biotechnology, 2019, 37(5): 505.
[14] LAXMINARAYAN R, SRIDHAR D, BLASER M, et al. Achieving global targets for antimicrobial resistance. Science, 2016, 353(6302): 874.
[15] HU S, CHANG J, LIU M Q, et al. Study on antibacterial effect of 45S5 Bioglass^®. Journal of Materials Science-Materials in Medicine, 2009, 20(1): 281.
[16] ZHANG E L, WANG X Y, CHEN M, et al. Effect of the existing form of Cu element on the mechanical properties, bio-corrosion and antibacterial properties of Ti-Cu alloys for biomedical application. Materials Science & Engineering C-Materials for Biological Applications, 2016, 69: 1210.
[17] REWAK-SOROCZYNSKA J, DOROTKIEWICZ-JACH A, DRULIS-KAWA Z, et al. Culture media composition influences the antibacterial effect of silver, cupric, and zinc ions against pseudomonas aeruginosa. Biomolecules, 2022, 12(7): 963.
[18] RAF A, YE J W, ZHANG S Q, et al. Copper(ii)-based coordination polymer nanofibers as a highly effective antibacterial material with a synergistic mechanism. Dalton Transactions, 2019, 48(48): 17810.
[19] YANG T T, WANG D H, LIU X Y.Antibacterial activity of an NIR-induced Zn ion release film.Journal of Materials Chemistry B, 2020, 8(3): 406.
[20] KERAYECHIAN N, MARDANY A, BAHRAINI F, et al. Evaluation of the antibacterial effects of the various nanoparticles coated orthodontic brackets: a systematic review and meta-analysis br. Medicina Balear, 2023, 38(3): 107
[21] LI J Y, ZHAI D, LV F, et al. Preparation of copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing. Acta Biomaterialia, 2016, 36: 254.
[22] LI Y H, HAN Y, WANG X Y, et al. Multifunctional hydrogels prepared by dual ion cross-linking for chronic wound healing. ACS Applied Materials & Interfaces, 2017, 9(19): 16054.
[23] JOHNSON A P, SABU C, NIVITHA K P, et al. Bioinspired and biomimetic micro- and nanostructures in biomedicine. Journal of Controlled Release, 2022, 343: 724.
[24] WANG B, ZHAO J Y, LU W X, et al. The preparation of lactoferrin/magnesium silicate lithium injectable hydrogel and application in promoting wound healing. International Journal of Biological Macromolecules, 2022, 220: 1501.
[25] GRANEY P L, BEN-SHAUL S, LANDAU S,#magtechI#et al. Macrophages of diverse phenotypes drive vascularization of engineered tissues. Science Advances, 2020, 6(18): eaay6391.
[26] XU P, XING M, HUANG H Z, et al. Calcium silicate-human serum albumin composite hydrogel decreases random pattern skin flap necrosis by attenuating vascular endothelial cell apoptosis and inflammation. Chemical Engineering Journal, 2021, 423: 130285.
[27] HUANG Y, WU C T, ZHANG X L, et al. Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration. Acta Biomaterialia, 2018, 66: 81.
[28] WANG H N, YU H Q, ZHOU X, et al. An overview of extracellular matrix-based bioinks for 3D bioprinting. Frontiers in Bioengineering and Biotechnology, 2022, 10: 905438.
[29] GARDEAZABAL L, IZETA A.Elastin and collagen fibres in cutaneous wound healing.Experimental Dermatology, 2024, 33(3): e15052.
[30] CAO Z, WANG X Y, JIANG C Q, et al. Thermo-sensitive hydroxybutyl chitosan/diatom biosilica hydrogel with immune microenvironment regulatory for chronic wound healing. International Journal of Biological Macromolecules, 2024, 262: 130189.
[31] QUE Y M, ZHANG Z W B, ZHANG Y X, et al. Silicate ions as soluble form of bioactive ceramics alleviate aortic aneurysm and dissection. Bioactive Materials, 2023, 25: 716.
[32] REFFITT D M, OGSTON N, JUGDAOHSINGH R, et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone, 2003, 32(2): 127.
[33] LV F, WANG J, XU P, et al. A conducive bioceramic/polymer composite biomaterial for diabetic wound healing. Acta Biomaterialia, 2017, 60: 128.
[34] LIN F S, LEE J J, LEE A K X, et al. Calcium silicate-activated gelatin methacrylate hydrogel for accelerating human dermal fibroblast proliferation and differentiation. Polymers, 2021, 13(1): 70.
[35] NOSRATI H, KHOUY R A, NOSRATI A, et al. Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis. Journal of Nanobiotechnology, 2021, 19(1): 1.
[36] DASHNYAM K, JIN G Z, KIM J H, et al. Promoting angiogenesis with mesoporous microcarriers through a synergistic action of delivered silicon ion and VEGF. Biomaterials, 2017, 116: 145.
[37] YU J, XU Y Z, ZHANG Z W B, et al. Strontium zinc silicate bioceramic composite electrospun fiber membrane for hair follicle regeneration in burn wounds. Composites Part B-Engineering, 2023, 266: 110953.
[38] LIU Y Q, LI T, MA H S, et al. 3D-printed scaffolds with bioactive elements-induced photothermal effect for bone tumor therapy. Acta Biomaterialia, 2018, 73: 531.
[39] YU Q Q, HAN Y M, TIAN T, et al. Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction. Biomaterials, 2019, 194: 25.
[40] MEHRABI T, MESGAR A S, MOHAMMADI Z.Bioactive glasses: a promising therapeutic on release strategy for enhancing wound healing.Acs Biomaterials Science & Engineering, 2020, 6(10): 5399.
[41] SHAO H J, WU X, DENG J J, et al. Application and progress of inorganic composites in haemostasis: a review. Journal of Materials Science, 2024, 59(17): 7169.
[42] LIU C Y, CUI X, DU Y B, et al. Unusual surface coagulation activation patterns of crystalline and amorphous silicate-based biominerals. Advanced Healthcare Materials, 2023, 12(20): 2300039.
[43] ZHENG C Y, LIU J X, BAI Q, et al. Preparation and hemostatic mechanism of bioactive glass-based membrane-like structure camouflage composite particles. Materials & Design, 2022, 223: 111116.
[44] WANG Y D, LUO M, LI T, et al. Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair. Bioactive Materials, 2023, 25: 319.
[45] GUO B L, DONG R N, LIANG Y P, et al. Haemostatic materials for wound healing applications. Nature Reviews Chemistry, 2021, 5(11): 773.
[46] MATAI I, KAUR G, SEYEDSALEHI A, et al. Progress in 3D bioprinting technology for tissue/organ regenerative engineering. Biomaterials, 2020, 226: 119536.
[47] YAN W C, DAVOODI P, VIJAYAVENKATARAMAN S, et al. 3D bioprinting of skin tissue: from pre-processing to final product evaluation. Advanced Drug Delivery Reviews, 2018, 132: 270.
[48] MA J G, QIN C, WU J F, et al. 3D printing of strontium silicate microcylinder-containing multicellular biomaterial inks for vascularized skin regeneration. Advanced Healthcare Materials, 2021, 10(16): 2100523.
[49] ZHOU F F, HONG Y, LIANG R J, et al. Rapid printing of bio-inspired 3D tissue constructs for skin regeneration. Biomaterials, 2020, 258: 120287.
[50] MA H S, FENG C, CHANG J, et al. 3D-printed bioceramic scaffolds: from bone tissue engineering to tumor therapy. Acta Biomaterialia, 2018, 79: 37.
[51] MA J G, QIN C, WU J F, et al. 3D multicellular micropatterning biomaterials for hair regeneration and vascularization. Materials Horizons, 2023, 10(9): 3773.
[52] XU H, LV F, ZHANG Y L, et al. Hierarchically micro-patterned nanofibrous scaffolds with a nanosized bio-glass surface for accelerating wound healing. Nanoscale, 2015, 7(44): 18446.
[53] ZHANG J P, ZENG Z, CHEN Y X,#magtechI#et al. 3D-printed GelMA/CaSiO₃ composite hydrogel scaffold for vascularized adipose tissue restoration. Regenerative Biomaterials, 2023, 10: rbad049.
[54] ZHOU Y L, GAO L, PENG J L, et al. Bioglass activated albumin hydrogels for wound healing. Advanced Healthcare Materials, 2018, 7(16): 1800144.
[55] MA W P, ZHENG Y, YANG G Z, et al. A bioactive calcium silicate nanowire-containing hydrogel for organoid formation and functionalization. Materials Horizons, 2024, 11(12): 2957.
[56] TEHRANY P M, RAHMANIAN P, REZAEE A, et al. Multifunctional and theranostic hydrogels for wound healing acceleration: an emphasis on diabetic-related chronic wounds. Environmental Research, 2023, 238: 117087.
[57] BAI Q, TENG L, ZHANG X L, et al. Multifunctional single-component polypeptide hydrogels: the gelation mechanism, superior biocompatibility, high performance hemostasis, and scarless wound healing. Advanced Healthcare Materials, 2022, 11(6): 2101809.
[58] ZENG Q Y, HAN Y, LI H Y, et al. Design of a thermosensitive bioglass/agarose-alginate composite hydrogel for chronic wound healing. Journal of Materials Chemistry B, 2015, 3(45): 8856.
[59] HAN Y, LI Y H, ZENG Q Y, et al. Injectable bioactive akermanite/alginate composite hydrogels for in situ skin tissue engineering. Journal of Materials Chemistry B, 2017, 5(18): 3315.
[60] MA H S, ZHOU Q, CHANG J, et al. Grape seed-inspired smart hydrogel scaffolds for melanoma therapy and wound healing. ACS Nano, 2019, 13(4): 4302.
[61] ZARACA F, VACCARILI M, ZACCAGNA G, et al. Can a standardised ventilation mechanical test for quantitative intraoperative air leak grading reduce the length of hospital stay after video-assisted thoracoscopic surgery lobectomy? Journal of visualized surgery, 2017, 3(12): 179.
[62] CHEN Y J, QIU Y Y, WANG Q Q, et al. Mussel-inspired sandwich-like nanofibers/hydrogel composite with super adhesive, sustained drug release and anti-infection capacity. Chemical Engineering Journal, 2020, 399: 125668.
[63] PLEGUEZUELOS-BELTRáN P, GáLVEZ-MARTíN P, NIETO-GARCíA D, et al. Advances in spray products for skin regeneration. Bioactive Materials, 2022, 16: 187.
[64] MA W P, MA H S, QIU P F, et al. Sprayable β-FeSi₂ composite hydrogel for portable skin tumor treatment and wound healing. Biomaterials, 2021, 279: 121225.
[65] DONG X, CHANG J, LI H Y.Bioglass promotes wound healing through modulating the paracrine effects between macrophages and repairing cells.Journal of Materials Chemistry B, 2017, 5(26): 5240.
[66] XU S X, ZHANG Y T, DAI B Y, et al. Green‐prepared magnesium silicate sprays enhance the repair of burn‐skin wound and appendages regeneration in rats and minipigs. Advanced Functional Materials, 2023, 34(9): 2307439.
[67] JOHN J V, MCCARTHY A, KARAN A, et al. Electrospun nanofibers for wound management. Chemnanomat, 2022, 8(7): e202100349.
[68] BAO F, CHANG J.Calcium silicate nanowires based composite electrospun scaffolds: preparation, ion release and cytocompatibility.Journal of Inorganic Materials, 2021, 36(11): 1199.
[69] JIANG Y Q, HAN Y M, WANG J, et al. Space-oriented nanofibrous scaffold with silicon-doped amorphous calcium phosphate nanocoating for diabetic wound healing. ACS Applied Bio Materials, 2019, 2(2): 787.