中空有序介孔有机硅的研究进展: 制备及在肿瘤治疗中的应用

doi:10.15541/jim20220435

无机材料学报 ›› 2022, Vol. 37 ›› Issue (11): 1192-1202.DOI: 10.15541/jim20220435 CSTR: 32189.14.10.15541/jim20220435

中空有序介孔有机硅的研究进展: 制备及在肿瘤治疗中的应用

张文君¹(), 赵雪莹¹, 吕江维¹(), 曲有鹏²

1.哈尔滨商业大学药学院, 哈尔滨 150076
2.哈尔滨工业大学生命科学与技术学院, 哈尔滨 150080

收稿日期:2022-07-23 修回日期:2022-09-14 出版日期:2022-11-20 网络出版日期:2022-09-15
通讯作者: 吕江维, 副教授, E-mail: pp198259@163.com
作者简介:张文君(1982-), 女, 博士, 副教授. E-mail: wenjun0501@126.com
基金资助:
国家重点研发计划(MB20160087);2019年哈尔滨商业大学青年人才专项计划项目(2019CX12)

Progresses on Hollow Periodic Mesoporous Organosilicas: Preparation and Application in Tumor Therapy

ZHANG Wenjun¹(), ZHAO Xueying¹, LÜ Jiangwei¹(), QU Youpeng²

1. School of Pharmacy, Harbin University of Commerce, Harbin 150076, China
2. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China

Received:2022-07-23 Revised:2022-09-14 Published:2022-11-20 Online:2022-09-15
Contact: LÜ Jiangwei, associate professor. E-mail: pp198259@163.com
About author:ZHANG Wenjun (1982-), female, PhD, associate professor. E-mail: wenjun0501@126.com
Supported by:
National Key Research and Development Program(MB20160087);Special Program for Young Talents of Harbin University of Commerce 2019(2019CX12)

摘要/Abstract

摘要：

随着介孔材料和生物医学的不断发展, 中空有序介孔有机硅(HPMOs)作为一种新型介孔硅材料, 具有高比表面积、高载药量、良好的生物相容性、多功能的有机-无机杂化框架、较低的细胞毒性以及可生物降解等特点,受到广泛关注, 以HPMOs为载体的药物递送系统得到多方持续开发, 为肿瘤治疗提供了新的策略。本文综述了近年来HPMOs的合成进展, 介绍了HPMOs的种类, 对硬模板法、液界面组装法和界面重组与转化法进行了详细的阐述, 并总结了其在肿瘤治疗中的应用进展。最后对其作为药物载体所面临的挑战及未来的发展趋势作了展望, 以期为HPMOs的制备及在肿瘤治疗中的应用研究提供参考。

关键词: 中空有序介孔有机硅, 硬模板法, 液界面组装法, 界面重组与转化法, 肿瘤治疗, 综述

Abstract:

With the development of mesoporous materials and biomedicine, hollow periodic mesoporous organosilicas (HPMOs), as a new type of mesoporous silicon material, stands out among many mesoporous materials because of its high specific surface area, high drug loading, good biocompatibility, multifunctional organic-inorganic hybrid framework, low cytotoxicity and biodegradability. Drug delivery systems based on HPMOs have been continuously developed, it provides a new strategy for tumor treatment. This article summarized the synthetic progress of HPMOs in recent years, briefly introduced the types of HPMOs, mainly expounded the hard template method, liquid interface assembly method and interface recombination-transformation method, and summarized its application in tumor therapy. Finally, challenges and future development trends as a drug carrier were prospected, in order to provide reference for the preparation and application of HPMOs in tumor therapy.

Key words: hollow periodic mesoporous organosilicas, hard template method, liquid-interface assembly method, interfacial recombination-transformation method, tumor therapy, review

中图分类号:

TB34

张文君, 赵雪莹, 吕江维, 曲有鹏. 中空有序介孔有机硅的研究进展: 制备及在肿瘤治疗中的应用[J]. 无机材料学报, 2022, 37(11): 1192-1202.

ZHANG Wenjun, ZHAO Xueying, LÜ Jiangwei, QU Youpeng. Progresses on Hollow Periodic Mesoporous Organosilicas: Preparation and Application in Tumor Therapy[J]. Journal of Inorganic Materials, 2022, 37(11): 1192-1202.

图/表 10

图1 HPMOs的制备方法及在肿瘤治疗中的应用

Fig. 1 Preparation of HPMOs and their application in tumor therapy

图2 单壳、蛋黄壳和多壳HPMOs结构示意图

Fig. 2 Structures of HPMOs, yolk-shell HPMOs and multishelled HPMOs

图 3 蛋黄壳和单壳HPMOs的合成策略

Fig. 3 Synthetic processes for yolk-shell structured HPMOs and HPMOs

图4 通过HF蚀刻获得的(a)蛋黄壳HPMOs和(b)单壳HPMOs的TEM照片[34]

Fig. 4 TEM images of (a) yolk-shell HPMOs and (b) HPMOs obtained by HF etching [34]

图5 界面重组与转化法制备HPMOs的过程[35]

Fig. 5 Preparation process of HPMOs by interface recombination-transformation method [35]

表1 HPMOs制备方法的比较

Table 1 Comparison of preparation methods of HPMOs

		Hard-core templating method	Liquid-interface assembly method	Interfacial reassembly and transformation method
Synthesis strategy	Difference	①Using solid particles as template ②Etchant required	①Using droplets or micelles as templates ②No etchant required	①No sacrificial template required ②No etchant required
Synthesis strategy	Similarity	The surfactant was extracted by HCl/EtOH solution
Influence factor		①Amount and type of etchant ②Etching temperature ③SNs size and organosilicon source concentration	Stability of droplets or micelles	Hydrothermal time and temperature
Advantages		Easy to control cavity diameter	①No sacrificial template required ②No etchant required ③Simple operation	①No sacrificial template required ②No etchant required
Disadvantages		①High costs ②Cumbersome operation ③Some of etchants are toxic	①Stability of droplets or micelles should be considered	High temperature of hydrothermal process

图6 HPMOs的药物递送过程[34]

Fig. 6 Drug delivery process of HPMOs [34]

图7 光响应型药物递送系统的DOX释放过程[67]

Fig. 7 DOX release process of photoresponsive drug delivery system[67]

图8 光控制药物释放的聚合方案[71]

Fig. 8 Scheme of the polymerization within HMPDINs for photocontrolled drug release [71]

图9 还原响应型药物递送系统的CO释放过程[72]

Fig. 9 CO release process of reduction responsive drug delivery system[72]

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中空有序介孔有机硅的研究进展: 制备及在肿瘤治疗中的应用

Progresses on Hollow Periodic Mesoporous Organosilicas: Preparation and Application in Tumor Therapy

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