可注射无机材料及其生物医学应用

doi:10.15541/jim20250441

无机材料学报

可注射无机材料及其生物医学应用

王金文^1,2, 杨振², 周欢², 夏丹¹, 杨磊^1,2

河北工业大学 1.材料科学与工程学院,天津 300130; 2.生命科学与健康工程学院,河北省生物医学材料与智能诊疗重点实验室,健康科学与工程中心,天津 300130

收稿日期:2025-10-31 修回日期:2026-01-19
通讯作者: 夏丹, 副教授. E-mail: xiad@hebut.edu.cn; 杨磊, 教授. E-mail: ylei@hebut.edu.cn
作者简介:王金文(1997-), 男, 博士研究生. E-mail: wangjinwen166@126.com
基金资助:
国家自然科学基金杰出青年科学家基金项目(82025025); 中国科学技术部“十四五”国家重点研发计划项目(2023YFC2412300); 国家自然科学基金联合基金项目(U23A6008); 河北省自然科学基金创新研究群体项目(H2022202007); 国家自然科学基金面上项目(32571559)

Biomedical Applications of Injectable Inorganic Biomaterials

WANG Jinwen^1,2, YANG Zhen², ZHOU Huan², XIA Dan¹, YANG Lei^1,2

1. School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China; 2. Center for Health Science and Engineering, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China

Received:2025-10-31 Revised:2026-01-19
Contact: XIA Dan, associate professor. E-mail: xiad@hebut.edu.cn; YANG Lei, professor. E-mail: ylei@hebut.edu.cn
About author:WANG Jinwen (1997-), male, PhD candidate. E-mail: wangjinwen166@126.com
Supported by:
National Science Fund for Distinguished Young Scholars of China (82025025); National Key Research and Development Program of China (2023YFC2412300); Joint Funds of the National Natural Science Foundation of China (U23A6008); Natural Science Foundation of Hebei Province of China (H2022202007); National Natural Science Foundation of China (32571559)

摘要/Abstract

摘要： 随着医工交叉领域和生物医学新兴研究方向的迅速发展,可注射医用材料以其在微创手术等领域的应用优势,在组织修复与再生、医学影像、疾病精准诊疗及微创化治疗等前沿领域得到广泛关注,并形成了一系列创新性医疗器械产品。在各类可注射医用材料中,无机材料因其独特的材料生物学特性、流变学性能以及自固化等特点,在微创骨科、肿瘤诊疗、组织替代与修复等领域展现出巨大的应用潜力和前景。本文综述了可注射无机材料的相关概念、原理及其在生物医学领域的最新进展。首先,介绍了无机材料可注射性的基本概念、原理及其调控因素(包括无机材料颗粒的几何特征,体系的液固比,液相黏度及材料体系的物理化学反应等)；然后,从临床应用角度阐述了可注射无机材料在硬组织修复、医学影像诊断、肿瘤治疗、皮肤和整形等领域的应用现状和研究进展,并分析了其优势和不足；最后,探讨了当前面临的挑战及未来发展趋势。本文有望为推动医用无机材料的应用研究和临床转化提供有益参考,进而促进相关医疗器械产品的技术创新和研发。

关键词: 无机材料, 可注射, 生物医学, 微创手术, 综述

Abstract: With the rapid advancement at the interface of medicine and engineering, as well as the emerging biomedical research, has formed a new research area of injectable biomaterials. Owing to their advantages in minimally invasive surgery, injectable biomaterials have been extensively investigated for biomedical research fields such as tissue repair and regeneration, medical imaging, precision diagnosis and therapy, and other minimally invasive therapies. Furthermore, many injectable biomaterials have been successfully translated into medical devices and products. Among injectable biomaterials, inorganic materials possess distinctive materiobiology properties, rheological properties, and unique self-setting behaviors, making them highly promising for biomedical applications including minimally invasive orthopedics, cancer theranostics and tissue repair. This review aims to introduce the basics of injectable inorganic materials and summarize their latest research advances and application progress. First, the fundamental concepts and governing principles of injectability are introduced, along with a discussion of key regulatory factors (e.g., geometric properties of the particles; liquid-to-solid ratio of the system, liquid phase viscosity, and physicochemical reactions). Second, clinicaly oriented research and development progress in inorganic injectable biomaterials are summarized, covering areas such as hard tissue repair, medical imaging diagnosis, cancer therapy, dermatology, and plastic surgery. Advantages and limitations of these materials are also analyzed. Finally, the key challenges and future research directions for injectable inorganic biomaterials are discussed. This article is expected to provide an overview of advancing application-oriented research and facilitating clinical translation of injectable inorganic biomaterials.

Key words: inorganic material, injectability, biomedical research, minimally invasive surgery, review

中图分类号:

R318

王金文, 杨振, 周欢, 夏丹, 杨磊. 可注射无机材料及其生物医学应用[J]. 无机材料学报, DOI: 10.15541/jim20250441.

WANG Jinwen, YANG Zhen, ZHOU Huan, XIA Dan, YANG Lei. Biomedical Applications of Injectable Inorganic Biomaterials[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250441.

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