无机材料学报 ›› 2022, Vol. 37 ›› Issue (11): 1192-1202.DOI: 10.15541/jim20220435

• 综述 • 上一篇    下一篇

中空有序介孔有机硅的研究进展: 制备及在肿瘤治疗中的应用

张文君1(), 赵雪莹1, 吕江维1(), 曲有鹏2   

  1. 1.哈尔滨商业大学 药学院, 哈尔滨 150076
    2.哈尔滨工业大学 生命科学与技术学院, 哈尔滨 150080
  • 收稿日期:2022-07-23 修回日期:2022-09-14 出版日期:2022-09-15 网络出版日期:2022-09-15
  • 通讯作者: 吕江维, 副教授, E-mail: pp198259@163.com
  • 作者简介:张文君(1982-), 女, 博士, 副教授. E-mail: wenjun0501@126.com
  • 基金资助:
    国家重点研发计划(MB20160087);2019年哈尔滨商业大学青年人才专项计划项目(2019CX12)

Progresses on Hollow Periodic Mesoporous Organosilicas: Preparation and Application in Tumor Therapy

ZHANG Wenjun1(), ZHAO Xueying1, LÜ Jiangwei1(), QU Youpeng2   

  1. 1. School of Pharmacy, Harbin University of Commerce, Harbin 150076, China
    2. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China
  • Received:2022-07-23 Revised:2022-09-14 Published:2022-09-15 Online:2022-09-15
  • Contact: LÜ Jiangwei, associate professor. E-mail: pp198259@163.com
  • About author:ZHANG Wenjun (1982-), female, PhD, associate professor. E-mail: wenjun0501@126.com
  • Supported by:
    National Key Research and Development Program(MB20160087);Special Program for Young Talents of Harbin University of Commerce 2019(2019CX12)

摘要:

随着介孔材料和生物医学的不断发展, 中空有序介孔有机硅(HPMOs)作为一种新型介孔硅材料, 具有高比表面积、高载药量、良好的生物相容性、多功能的有机-无机杂化框架、较低的细胞毒性以及可生物降解等特点,受到广泛关注, 以HPMOs为载体的药物递送系统得到多方持续开发, 为肿瘤治疗提供了新的策略。本文综述了近年来HPMOs的合成进展, 介绍了HPMOs的种类, 对硬模板法、液界面组装法和界面重组与转化法进行了详细的阐述, 并总结了其在肿瘤治疗中的应用进展。最后对其作为药物载体所面临的挑战及未来的发展趋势作了展望, 以期为HPMOs的制备及在肿瘤治疗中的应用研究提供参考。

关键词: 中空有序介孔有机硅, 硬模板法, 液界面组装法, 界面重组与转化法, 肿瘤治疗, 综述

Abstract:

With the development of mesoporous materials and biomedicine, hollow periodic mesoporous organosilicas (HPMOs), as a new type of mesoporous silicon material, stands out among many mesoporous materials because of its high specific surface area, high drug loading, good biocompatibility, multifunctional organic-inorganic hybrid framework, low cytotoxicity and biodegradability. Drug delivery systems based on HPMOs have been continuously developed, it provides a new strategy for tumor treatment. This article summarized the synthetic progress of HPMOs in recent years, briefly introduced the types of HPMOs, mainly expounded the hard template method, liquid interface assembly method and interface recombination-transformation method, and summarized its application in tumor therapy. Finally, challenges and future development trends as a drug carrier were prospected, in order to provide reference for the preparation and application of HPMOs in tumor therapy.

Key words: hollow periodic mesoporous organosilicas, hard template method, liquid-interface assembly method, interfacial recombination-transformation method, tumor therapy, review

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