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无机材料学报

无机材料学报

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无机生物活性材料调控心肌再生的研究进展

罗晓民1, 乔志龙1, 刘颍1, 杨晨3, 常江2,3   

  1. 1.陕西科技大学 轻工科学与工程学院 生物质与功能材料研究所,西安 710021;
    2.中国科学院上海硅酸盐研究所, 高性能陶瓷和超微结构国家重点实验室,上海 200050;
    3.国科温州研究院 浙江省组织修复材料工程研究中心,温州 325000
  • 收稿日期:2025-01-08 修回日期:2025-02-18
  • 通讯作者: 常 江, 研究员. E-mail: jchang@mail.sic.ac.cn
  • 作者简介:罗晓民 (1966-), 女, 教授. E-mail: luoxiaomin@sust.edu.cn
  • 基金资助:
    国家自然科学基金 (2227825); 国科温州研究院启动项目(WIUCASQD2020013, WIUCASQD2021030)

Inorganic Bioactive Materials Regulate Myocardial Regeneration

LUO Xiaomin1, QIAO Zhilong1, LIU Ying1, YANG Chen3, CHANG Jiang2,3   

  1. 1. College of Bioresources Chemical and Materials Engineering, Institute of Biomass & Functional Materials, Shaanxi University of Science & Technology, Xi’an 710021, China;
    2. State Key Laboratory of High-performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China;
    3. Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China
  • Received:2025-01-08 Revised:2025-02-18
  • Contact: CHANG Jiang, professor. E-mail: jchang@mail.sic.ac.cn
  • About author:LUO Xiaomin (1966-), female, professor. E-mail: luoxiaomin@sust.edu.cn
  • Supported by:
    National Natural Science Foundation of China (2227825); Seed grants from the Wenzhou Institute, University of Chinese Academy of Sciences (WIUCASQD2020013, WIUCASQD2021030)

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摘要： 心血管疾病是全球人类死亡的主要原因,其中心肌梗死对人类的生命健康威胁更为严重。但目前可用的药物和手术干预治疗几乎均为姑息性措施,并未从根本上解决心肌梗死造成的心肌细胞死亡问题。而近年来的再生医学生物材料研究有望提供新的解决方案。无机生物活性材料可在体内与细胞和组织发生相互作用并激活细胞,从而有效调控组织再生和损伤修复,因此在再生医学和组织工程领域引起广泛的关注。其中以硅酸盐为代表的硅基生物材料（如生物陶瓷、生物玻璃等）、碳基纳米材料、金属氧化物等在促进心肌修复和再生方面显示出巨大应用前景。本文重点介绍了无机生物活性材料在心肌再生和修复领域的最新进展,概述了它们的材料类型和作用机制,最后探讨了无机生物活性材料在临床转化过程中所面临的挑战,并展望了其未来的发展前景。

关键词: 无机生物活性材料, 心肌再生, 金属氧化物, 碳基材料, 硅酸盐生物材料, 综述

Abstract: Cardiovascular disease is the leading cause of death worldwide, with myocardial infarction (MI) being a serious threat to human health and life. Current pharmacological and surgical interventions primarily serve as palliative measures, failing to address the root cause of cardiomyocyte death post-MI. Recent advances in regenerative biomedical materials, however, offer promising solutions. Inorganic bioactive materials, capable of interacting with cells and tissues to activate cellular responses and modulate tissue regeneration, have garnered significant attention in regenerative medicine and tissue engineering. Silicate-based biomaterials (e.g., bioceramics, bioactive glasses), carbon-based nanomaterials, and metal oxides exhibit remarkable potential in promoting myocardial repair and regeneration. This review highlights the latest progress in inorganic bioactive materials for myocardial regeneration and repair, elucidates their material categories and mechanisms of action, and discusses current challenges in clinical translation, while providing insights into future research directions.

Key words: inorganic bioactive material, myocardial regeneration, metal oxide, carbon-based material, silicate biomaterial, review

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