Construction of Hydroxyapatite Nanoceramics with High Mechanical Strength and Efficiency in Promoting the Spreading and Viability of Osteoblasts

doi:10.15541/jim20200395

Abstract

Abstract:

The present study focuses on the construction of HA nanoceramics with excellent mechanical property and osteogenic activity, and the correlation between HA precursor powders and resulting ceramics. Three precursor powders were used, i.e. HA-40 synthesized at 40 ℃, HA-40PEG synthesized at 40 ℃ with PEG as a template, and HA-80 synthesized at 80 ℃. The results showed that grain sizes of three HA ceramics prepared by HA-40, HA-40PEG, and HA-80 precursors were (217.87±57.53), (123.22±20.16), and (316.65±68.91) nm, respectively. It demonstrated that compared with HA-40 and HA-80, HA-40PEG was more beneficial for fabricating HA nanoceramics. Among three resulting ceramics, HA-40PEG displayed the highest comprehensive strength (~300 MPa). In addition, the nano-scale HA-40PEG ceramics promoted better cell spreading and proliferation than those of submicro-scale HA-40 and HA-80 ceramics. These findings suggest that the preparation of HA precursor powders plays an important role in fabricating HA nanoceramics with simultaneous improvement of mechanical and biological properties.

Key words: hydroxyapatite, nanoceramics, initial powder, density, cellular viability

CLC Number:

TQ174

WU Yonghao, LI Xiangfeng, ZHU Xiangdong, ZHANG Xingdong. Construction of Hydroxyapatite Nanoceramics with High Mechanical Strength and Efficiency in Promoting the Spreading and Viability of Osteoblasts[J]. Journal of Inorganic Materials, 2021, 36(5): 552-560.

Figures/Tables 8

References 42

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Sample	Particle size, D₅₀/nm	Crystallinity, X_c/%	Specific surface area/(m²·g^-1)	Crystallinity index	Maturity index
HA-40	(124.62±28.71)	31.76	(89.76±3.96)	5.91	2.02
HA-40PEG	(65.16±31.23)	39.48	(81.40±0.66)	5.31	1.91
HA-80	(221.50±48.82)	77.94	(41.76±0.71)	7.45	1.86

Sample	Particle size, D₅₀/nm	Crystallinity, X_c/%	Specific surface area/(m²·g^-1)	Crystallinity index	Maturity index
HA-40	(124.62±28.71)	31.76	(89.76±3.96)	5.91	2.02
HA-40PEG	(65.16±31.23)	39.48	(81.40±0.66)	5.31	1.91
HA-80	(221.50±48.82)	77.94	(41.76±0.71)	7.45	1.86

Sample	Crystallinity, X_c/%	Surface roughness, R_a/nm	Contact angle/(°)	Grain size/nm	Relative density/%
HA-40	97.48	(61.49±5.65)	(69.20±6.94)	(217.87±57.53)	(94.90±2.27)
HA-40PEG	96.92	(66.70±2.81)	(56.07±0.42)	(123.22±20.16)	(93.45±3.32)
HA-80	98.33	(57.81±3.44)	(79.83±1.99)	(316.65±68.91)	(85.57±0.91)

Sample	Crystallinity, X_c/%	Surface roughness, R_a/nm	Contact angle/(°)	Grain size/nm	Relative density/%
HA-40	97.48	(61.49±5.65)	(69.20±6.94)	(217.87±57.53)	(94.90±2.27)
HA-40PEG	96.92	(66.70±2.81)	(56.07±0.42)	(123.22±20.16)	(93.45±3.32)
HA-80	98.33	(57.81±3.44)	(79.83±1.99)	(316.65±68.91)	(85.57±0.91)