无机材料学报 ›› 2020, Vol. 35 ›› Issue (8): 867-881.DOI: 10.15541/jim20190561 CSTR: 32189.14.10.15541/jim20190561
所属专题： 封面文章； 生物材料论文精选(2020)
董少杰1,2(
),王旭东2,沈国芳2,3,王晓虹1(),林开利2()
收稿日期:2019-11-04
修回日期:2019-11-24
出版日期:2020-08-20
网络出版日期:2020-01-20
作者简介:董少杰(1992-), 男, 博士研究生. E-mail: 基金资助:
DONG Shaojie1,2(),WANG Xudong2,SHEN Steve Guofang2,3,WANG Xiaohong1(),LIN Kaili2()
Received:2019-11-04
Revised:2019-11-24
Published:2020-08-20
Online:2020-01-20
Supported by:摘要：
生物陶瓷支架具有良好的生物相容性和引导组织再生特性, 并可提供多孔的表面形貌和孔道结构, 以促进新生组织的长入, 在硬组织修复和骨组织工程支架领域获得了广泛的关注和临床应用。当前, 生物陶瓷支架仍然存在骨诱导活性差、生物功能单一、力学性能差等缺陷, 极大限制了它们的临床治疗效果和应用范围。本文从生物陶瓷支架的功能改性角度出发, 对材料实施表面功能涂层修饰、微纳结构改性、功能元素掺杂、力学增强等策略, 及其在改善植入体生物相容性、促进成骨活性、药物递送、抗肿瘤和抗菌等方面的应用进展进行了归纳和总结, 并对功能改性生物陶瓷支架的未来发展趋势作了展望。
中图分类号:
董少杰,王旭东,沈国芳,王晓虹,林开利. 生物陶瓷支架的功能改性及应用研究进展[J]. 无机材料学报, 2020, 35(8): 867-881.
DONG Shaojie,WANG Xudong,SHEN Steve Guofang,WANG Xiaohong,LIN Kaili. Research Progress on Functional Modifications and Applications of Bioceramic Scaffolds[J]. Journal of Inorganic Materials, 2020, 35(8): 867-881.
图1 无定型碳涂层β-TCP支架的制备流程图(a)及材料对BMSCs细胞黏附(b)、ALP表达(c)的调控[18]
Fig. 1 Procedure for the fabricating of β-TCP scaffold coated with amorphous carbon (a), and adhesion (b) and ALP activity (c) of BMSCs cultured on the samples[18]
图2 白硅钙石支架的(a)制备及表面微纳结构改性, 促(b)软骨和(c)BMSCs细胞的黏附, 及其促进(d)成软骨和(e)成骨分化相关基因表达的能力[28]
Fig. 2 (a) Fabrication procedure of bredigite (BRT) scaffolds with modified micro/nanostructure on the surface, cell adhesion behavior of (b) chondrocytes and (c) BMSCs cultured on different scaffolds, and expression level of (d) chondrogenesis of chondrocytes and (e) osteogenesis related genes of BMSCs cultured on different scaffolds, respectively[28]
图3 β-TCP和CA修饰的β-TCP陶瓷的(a)SEM形貌(黄色箭头为碳气凝胶)和(b)原子力显微镜结构, (c)光热能力, (d)材料调控BMSCs黏附及FN表达和(e)大鼠颅骨缺损修复能力[32]
Fig. 3 Surface morphology of β-TCP and CA coated β-TCP (β-TCP-C) detected with (a) SEM (yellow, CA) and (b) atomic force microscope, (c) photothermal performance of β-TCP and β-TCP-C, (d) cell adhesion behavior and FN-expression of BMSCs cultured on β-TCP and β-TCP-C, and (e) osteogenesis capability of β-TCP and β-TCP-C scaffold in vivo[32]
图4 CS和Sr-CS支架的(a)SEM照片, 材料浸提液对(b)BMSCs-OVX成骨分化和(c)HUVECs成血管分化的促进作用, (d)颅骨(d1, CS; d2, Sr-CS)micro-CT影像和(e)定量分析, 及(f)新生骨的VG染色结果(左: CS; 右: Sr-CS)[39]
Fig. 4 (a) Morphologies of CS and Sr-CS scaffolds, expression level of (b) osteogenic genes of BMSCs-OVX and (c) angiogenic genes of HUVECs cultured with the extracts of CS and Sr-CS scaffolds, (d) micro-CT images (d1, CS; d2, Sr-CS), (e) morphometric analysis and (f) VG staining results of the new formed bone (left: CS; right: Sr-CS)[39]
图5 仿生梯度多孔结构β-TCP支架的(a)结构示意图及(b)数码照片, (c)天然骨(c1~c2)皮质-松质交界区与支架(c3~c4)高密度-低密度交界区SEM照片, (d)高密度/低密度区域面积比与材料压缩强度的定量函数关系[61]
Fig. 5 (a) Structure-diagram and (b) digital images of biomimetic β-TCP scaffolds (c) SEM images of (c1-c2) compact/cancellous interface of natural bone and (c3-c4) dense/porous interface of scaffold, (d) function curves of compression strength, modulus of elasticity and dense/porous cross-sectional area ratio[61]
图6 Cu, Fe, Mn, Co元素掺杂生物玻璃支架的截面(a1~a5)和侧面(b1~b5)形貌及(c~e)促成骨分化能力[55]
Fig. 6 Morphologies (top view (a) and side view (b)) of 3D printing bioglass scaffolds containing Cu, Fe, Mn, Co elements and pure bioglass, (c-e) expression of osteogenic genes of BMSCs cultured on culture plate, 3D printing bioglass scaffolds containing Cu, Fe, Mn, Co elements doping and pure bioglass[55]
图7 BP-BG支架的制备以及骨肉瘤治疗-骨缺损修复机制示意图[16]
Fig. 7 Schematic illustration of fabrication process of BP-BG scaffold and stepwise therapeutic strategy for the elimination of osteosarcoma followed by osteogenesis by BP-BG[16]
图8 功能改性的多功能AKT-Fe3O4-CaO2支架的(a)作用机制、(b)表面形貌、(c)可调控磁化强度、(d~f)骨肿瘤的磁热-催化联合治疗及(g~i)促进成骨基因表达和肿瘤治疗后的骨缺损修复[7]
Fig. 8 (a) Schematic diagram of AKT-Fe3O4-CaO2 scaffold functioning to obtain efficient tumor ablation and enhanced bone regeneration, (b) SEM images of AKT and AKT-Fe3O4-CaO2 scaffold (red arrows: Fe3O4 nanoparticles; yellow arrows: CaO2 nanoparticles), (c) magnetization curves of AKT-Fe3O4-CaO2 scaffolds soaked in Fe3O4 suspensions with various concentrations, (d) in vitro therapeutic effect of AKT-Fe3O4-CaO2 scaffold, (e) infrared images of nude mice in alternating magnetic fields, (f) in vivo therapeutic effect of AKT-Fe3O4-CaO2 scaffold, (g, h) expression of osteogenic genes of BMSCs, and (i) regeneration of cranium defects implanted with AKT and AKT-Fe3O4-CaO2 scaffolds[7] (1 emu?g-1= 1×103 A?m-1?g-1, 1 Oe=80 A?m-1)
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