新型改性的n-HA与PLGA复合材料的制备及性能研究

doi:10.3724/SP.J.1077.2013.12502

无机材料学报 ›› 2013, Vol. 28 ›› Issue (7): 751-756.DOI: 10.3724/SP.J.1077.2013.12502 CSTR: 32189.14.SP.J.1077.2013.12502

新型改性的n-HA与PLGA复合材料的制备及性能研究

蒋立新^1,2, 蒋柳云¹, 马驰^1,2, 韩崇涛^1,2, 徐莉娟^1,2, 熊成东¹

(1. 中国科学院成都有机化学研究所, 成都 610041; 2. 中国科学院大学, 北京 100039)

收稿日期:2012-08-17 修回日期:2012-10-18 出版日期:2013-07-20 网络出版日期:2013-06-19
作者简介:蒋立新(1987–), 男, 硕士研究生. E-mail: jlx198765@126.com
基金资助:
中国科学院“西部之光”人才培养计划项目; 国家自然科学基金(31000440)

Preparation and Characterization of Nano-hydroxyapatite/PLGA Composites with Novel Surface-modified Nano-hydroxyapatite

JIANG Li-Xin^{1, 2}, JIANG Liu-Yun¹, MA Chi^{1, 2}, HAN Chong-Tao^{1, 2}, XU Li-Juan^{1, 2}, XIONG Cheng-Dong¹

(1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; 2. Graduated University of the Chinese Academy of Sciences, Beijing 100049, China)

Received:2012-08-17 Revised:2012-10-18 Published:2013-07-20 Online:2013-06-19
About author:JIANG Li-Xin. E-mail: jlx198765@126.com
Supported by:
Talent Training Project of West Light Foundation of Chinese Academy of Science; National Natural Science Foundation of China (31000440)

摘要/Abstract

摘要： 采用硅烷偶联剂(KH550)和L-丙交酯LLA联合接枝处理的新方法对纳米羟基磷灰石(n–HA)进行表面改性, 然后将其与聚乳酸-羟基乙酸(PLGA)作不同比例复合(n-HA为3wt%、10wt%、20wt%及30wt%), 得到改性n-HA/PLGA复合材料(g-n-HA/PLGA)。将其与未改性n-HA及未改性n-HA/PLGA复合材料作对比检测。结果表明, 该联合处理方法是n-HA进行表面接枝改性的新型有效方法。且改性处理后的n-HA与未改性处理的n-HA相比, 能更好地在PLGA基体中分散均匀, 并能提高PLGA结晶能力和PLGA的力学性能。当改性处理后的n-HA添加量为10wt%时, 其复合材料抗弯强度和拉伸强度分别比未改性n-HA/PLGA提高14.4%和11.3%。该新型g-n-HA/PLGA复合材料有望用作骨折固定材料。

关键词: 纳米羟基磷灰石, 表面改性, 复合材料, PLGA

Abstract: Nano-hydroxyapatite (n-HA) was modified by a new method of combining silane coupling reagent (KH550) with surface-grafting L-lactide LLA. Then, the surface-modified n-HA (g-n-HA) was introduced into poly(lactic-co-glycolic acid) (PLGA) to prepare a series of g-n-HA/PLGA composites with the concentration of 3wt%, 10wt%, 20wt% and 30wt%. The properties of the g-n-HA/PLGA composites were characterized and compared with PLGA and n-HA/PLGA composites. The results show that n-HA is successfully modified by KH550 and L-LA. The g-n-HA particles could disperse more uniformly in PLGA matrix and promote PLGA to crystallize. The obtained g-n-HA/PLGA composites has better mechanical properties than those of n-HA/PLGA composites with the same amount of n-HA. Moreover, the bending and tensile strength of g-n-HA/PLGA composite containing 10wt% g-n-HA are 14.4% and 11.3% which is higher than that of pure PLGA, respectively. Therefore, the g-n-HA/PLGA composite is promising for bone fracture internal fixation material in future.

Key words: nano-hydroxyapatite (n-HA), surface modification, composite, PLGA

中图分类号:

R318

蒋立新, 蒋柳云, 马驰, 韩崇涛, 徐莉娟, 熊成东. 新型改性的n-HA与PLGA复合材料的制备及性能研究[J]. 无机材料学报, 2013, 28(7): 751-756.

JIANG Li-Xin, JIANG Liu-Yun, MA Chi, HAN Chong-Tao, XU Li-Juan, XIONG Cheng-Dong. Preparation and Characterization of Nano-hydroxyapatite/PLGA Composites with Novel Surface-modified Nano-hydroxyapatite[J]. Journal of Inorganic Materials, 2013, 28(7): 751-756.

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新型改性的n-HA与PLGA复合材料的制备及性能研究

Preparation and Characterization of Nano-hydroxyapatite/PLGA Composites with Novel Surface-modified Nano-hydroxyapatite

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