Effect of Citric Acid Concentration on the Properties of Borate Glass Bone Cement

doi:10.15541/jim20160598

Abstract

Abstract:

A novel injectable borate glass bone cement (BGBC) was prepared by using citric acid-β glycerophosphate-chitosan solution as setting solution. The effect of citric acid (H₃Cit) concentration (0.1, 0.2 and 0.4 g/mL) on the properties of BGBC was investigated by using vicat apparatus, universal testing machine, XRD, FTIR, and SEM-EDS measurements. The experimental results indicate that H₃Cit concentration significantly influences setting time and injectability of BGBC. At the H₃Cit concentration of 0.2 g/mL, BGBC obtains the shortest setting time of (16±0.5) min and best injectability, which is almost fully injectable. It compressive strength increases with the increase of H₃Cit concentration, with the maximum compressive strength up to (26.7±1.9) MPa. SEM images show that a large amount of nanoparticles are formed in the BGBC. XRD, FTIR and EDS results confirm that these nanoparticles contain borates, phosphates and phosphates. Furthermore, formation of borate crystals in the BGBC is influenced by H₃Cit concentration. Immersion experiment of borate glass particles into phosphate buffer with different H₃Cit concentrations shows that the degradation of borate glass is accelerated by H₃Cit.

Key words: citric acid, borate glass, bone cement, property

CLC Number:

TB332

LI Hai-Bin, WANG De-Ping, WU Ying-Ying, YAO Ai-Hua, YE Song. Effect of Citric Acid Concentration on the Properties of Borate Glass Bone Cement[J]. Journal of Inorganic Materials, 2017, 32(8): 831-836.

Figures/Tables 10

Table 1 Liquid composition of samples

Sample	H₃Cit/(g·mL^-1)	CS/(g·mL^-1)	GP /(g·mL^-1)
S1	0.1	0.005	0.056
S2	0.2	0.005	0.056
S3	0.4	0.005	0.056

Fig. 1 Injection curve of samples

Table 2 Setting time and injectability of samples

Sample	Setting time/min	Injectability/%	Injection force/N
S1	40±2.0	75±7	86.5
S2	16±0.5	>95	28.1
S3	20±1.0	35±10	17.6

Fig. 2 Compressive strength of samples

Fig. 3 XRD patterns of samples

Fig. 4 Infrared spectra of samples

Fig. 5 SEM images of the fracture surfaces of samples ((a) S1; (b) S2; (c) S3) and EDS pattern of the boxed area in Fig. (b)

Fig. 6 Degradation curves of borate glass in the PBS-0, PBS-0.1, PBS-0.2 and PBS-0.4 (a) and the B ion release concentration in the immersion solution (b)

Fig. 7 Variation of pH of immersion solutions with the immersion time

Fig. 8 Schematic diagram of setting mechanism of bone cement

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