Preparation and Characterization of Bioactive Poly (Lactic Acid)/SiO2-CaO Composite Membranes

doi:10.3724/SP.J.1077.2011.11125

Journal of Inorganic Materials ›› 2011, Vol. 26 ›› Issue (9): 998-1002.DOI: 10.3724/SP.J.1077.2011.11125

• Research Letter • Previous Articles Next Articles

Preparation and Characterization of Bioactive Poly (Lactic Acid)/SiO₂-CaO Composite Membranes

LI Jin-Bo^1,2, LIU Xuan-Yong², LI Wei-Feng³, ZHU Jian-Hao⁴

(1. College of Materials Science and Engineering, Hunan University, Changsha 410082, China; 2. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; 3. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China; 4. Department of Physics & Materials Science, City University of Hong Kong, Hong Kong, China)

Received:2011-03-02 Revised:2011-04-26 Published:2011-09-20 Online:2011-08-19
About author:LI Jin-Bo (1976-), male, candidate of PhD. E-mail: lijinbo_yin@163.com
Supported by:
Shanghai Science and Technology R&D Fund (1052nm06600); National Natural Science Foundation of China (51071168); Shanghai-Unilever Research and Development Fund (09520715200)

Abstract

Abstract: A novel porous poly (lactic acid) (PLA)/SiO₂-CaO(n(SiO₂):n(CaO)=1:1) composite membrane is synthesized by Sol-Gel method. The microstructure and composition of the composite membranes are characterized by Fourier transform infrared (FTIR) spectroscope and scanning electron microscope (SEM). The surface zeta potential is monitored by the SurPASS electrokinetic analyzer. The bioactivity is evaluated by investigating the formation of apatite on the surface of the composite membranes in simulated body fluids and the cytotoxicity is evaluated by MTT experiments. After soaked in simulated body fluids for 7d, the surface of the PLA/SiO₂-CaO composite membranes is covered by an apatite layer with an orderly ring structure. The surface zeta potential of the composite membranes decreases with increasing SiO₂-CaO contents suggesting better bioactivity. The PLA/SiO₂-CaO composite membranes do not induce cytotoxcity to MG-63 cells and support cell proliferation.

Key words: PLA, SiO₂-CaO, Zeta potential, bioactivity, MTT

CLC Number:

TB332

LI Jin-Bo, LIU Xuan-Yong, LI Wei-Feng, ZHU Jian-Hao. Preparation and Characterization of Bioactive Poly (Lactic Acid)/SiO₂-CaO Composite Membranes[J]. Journal of Inorganic Materials, 2011, 26(9): 998-1002.

References

[1] Zhang Z, Feng S S. The drug encapsulation efficiency, in vitro drug release, cellular uptake and cytotoxicity of paclitaxel-loaded poly (lactide)-tocopheryl polyethylene glycol succinate nanoparticles. Biomaterials, 2006, 27(21): 4025-4033.

[2] Schugens C, Grandfils C, Jerome R, et al. Preparation of a macroporous biodegradable polylactide implant for neuronal transplantation. J. Biomed. Mater. Res., 1995, 29(11): 1349-1362.

[3] Janorkar A V, Metters A T, Hirt D E. Modification of poly (lactic acid) films: enhanced wettability from surface-confined photografting and increased degradation rate due to an artifact of the photografting process. Macromolecules, 2004, 37(24): 9151-9159.

[4] Tokiwa Y, Calabia B P. Biodegradability and biodegradation of poly(lactide). Appl. Microbiol. Biotechnol., 2006, 72(2): 244-251.

[5] Hench L L, Anderson O. Hench L L, Wilson J, editors. An Introduction to Bioceramics. Singapore: World Scientific, 1993: 41-62.

[6] Kokubo T. Surface chemistry of bioactive glass-ceramics. J. Non-Cryst. Solids, 1990, 120(1/2/3): 138-151.

[7] Liu X Y, Ding C X. Apatite formed on the surface of plasma sprayed wollastonite coating immersed in simulated body fluid. Biomaterials, 2001, 22(14): 2007-2012.

[8] Liu X Y, Tao S Y, Ding C X. Bioactivity of plasma sprayed dicalcium silicate coatings. Biomaterials, 2002, 23(3): 963-968.

[9] Ni S, Chang J, Chou L. A novel bioactive porous CaSiO3 scaffold for bone tissue engineering. J. Biomed. Mater. Res. A, 2006, 76(1): 196-205.

[10] Cai X, Shen X Y, Chen W X, et al. Preparation and characterization of homogeneous chitosan-polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties. Acta. Biomater., 2009, 5(7): 2693-2703.

[11] Yan S F, Yin J B, Yang J Y. Structural characteristics and thermal properties of plasticized poly (L-lactide)-silica nanocomposites synthesized by Sol–Gel method. Mater. Lett., 2007, 61(13): 2683-2686.

[12] Maiti P, Yamada K, Okamoto M, et al. New polylactide/layered silicate nanocomposites:-role of organoclays. Chem.Mater., 2002, 14(11): 4654-4661.

[13] Hofacker R, Mechtel M, Mager M, et al. Sol-Gel: a new tool for coatings chemistry. Prog. Org. Coat., 2002, 45(2/3): 159-164.

[14] Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity. Biomaterials, 2006, 27(15): 2907-2915.

[15] Liu H C, Lee I C, Wang J H, et al. Preparation of PLLA membranes with different morphologies for culture of MG-63 cells. Biomaterials, 2004, 25(18): 4047-4056.

[16] Kim I Y, Kawachi G, Kikuta K, et al. Preparation of bioactive spherical particles in the CaO–SiO2 system through Sol–Gel processing under coexistence of poly (ethylene glycol). J. Eur. Ceram. Soc., 2008, 28(8): 1595-1602.

[17] Murugan R, Ramakrishna S. In situ formation of recombinant humanlike collagen–hydroxyapatite nanohybrid through bionic approach. Appl. Phys. Lett., 2006, 88(19): 193124-1-3.

[18] Weng J, Liu Q, Wolke J G C, et al. Formation and characteristics of the apatite layer on plasma-sprayed hydroxyapatite coatings in simulated body fluid. Biomaterials, 1997, 18(15): 1027–1035.

[19] Takadama H, Kim H M, Kokubo T, et al. Mechanism of biomineralization of apatite on a sodium silicate glass: TEM-EDX study in vitro. Chem. Mater., 2001, 13(3): 1108-1113.

[20] Gao T J, Aro H T, Yl-nen H, et al. Silica-based bioactive glasses modulate expression of bone morphogenetic protein-2 mRNA in Saos-2 osteoblasts in vitro. Biomaterials, 2001, 22(12): 1475-1483.

Preparation and Characterization of Bioactive Poly (Lactic Acid)/SiO₂-CaO Composite Membranes

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	MA Wen, SHEN Zhe, LIU Qi, GAO Yuanming, BAI Yu, LI Rongxing. Preparation of Y₂O₃ Coating by Suspension Plasma Spraying and Its Resistance to Plasma Etching [J]. Journal of Inorganic Materials, 2024, 39(8): 929-936.
[2]	WU Xiangquan, TENG Jiachen, JI Xiangxu, HAO Yubo, ZHANG Zhongming, XU Chunjie. Textured Porous Al₂O₃-SiO₂ Composite Ceramic Platelet-sphere Slurry: Characteristics and Simulation of Light Intensity Distribution [J]. Journal of Inorganic Materials, 2024, 39(7): 769-778.
[3]	LI Jiaqi, LI Xiaosong, LI Xuanhe, ZHU Xiaobing, ZHU Aimin. Transition Metal-doped Manganese Oxide: Synthesis by Warm Plasma and Electrocatalytic Performance for Oxygen Evolution Reaction [J]. Journal of Inorganic Materials, 2024, 39(7): 835-844.
[4]	LI Jie, LUO Zhixin, CUI Yang, ZHANG Guangheng, SUN Luchao, WANG Jingyang. CMAS Corrosion Resistance of Y₃Al₅O₁₂/Al₂O₃ Ceramic Coating Deposited by Atmospheric Plasma Spraying [J]. Journal of Inorganic Materials, 2024, 39(6): 671-680.
[5]	LU Hao, XU Shengrui, HUANG Yong, CHEN Xing, XU Shuang, LIU Xu, WANG Xinhao, GAO Yuan, ZHANG Yachao, DUAN Xiaoling, ZHANG Jincheng, HAO Yue. Epitaxy Single Crystal GaN on AlN Prepared by Plasma-enhanced Atomic Layer Deposition [J]. Journal of Inorganic Materials, 2024, 39(5): 547-553.
[6]	LI Junsheng, ZENG Liang, LIU Rongjun, WANG Yanfei, WAN Fan, LI Duan. Functional Strontium Tantalum Oxynitride Ceramics: Efficient Synthesis, Densification and Dielectric Performance [J]. Journal of Inorganic Materials, 2023, 38(8): 885-892.
[7]	NI Xiaoshi, LIN Ziyang, QIN Muyan, YE Song, WANG Deping. Bioactivity and Mechanical Property of PMMA Bone Cement: Effect of Silanized Mesoporous Borosilicate Bioglass Microspheres [J]. Journal of Inorganic Materials, 2023, 38(8): 971-977.
[8]	XU Zhou, LIU Yuxuan, CHI Junlin, ZHANG Tingting, WANG Shuyue, LI Wei, MA Chunhui, LUO Sha, LIU Shouxin. Horseshoe-shaped Hollow Porous Carbon: Synthesis by Hydrothermal Carbonization with Dual-template and Electrochemical Property [J]. Journal of Inorganic Materials, 2023, 38(8): 954-962.
[9]	FANG Renrui, REN Kuan, GUO Zeyu, XU Han, ZHANG Woyu, WANG Fei, ZHANG Peiwen, LI Yue, SHANG Dashan. Associative Learning with Oxide-based Electrolyte-gated Transistor Synapses [J]. Journal of Inorganic Materials, 2023, 38(4): 399-405.
[10]	QIU Haiyang, MIAO Guangtan, LI Hui, LUAN Qi, LIU Guoxia, SHAN Fukai. Effect of Plasma Treatment on the Long-term Plasticity of Synaptic Transistor [J]. Journal of Inorganic Materials, 2023, 38(4): 406-412.
[11]	WANG Jingyu, WAN Changjin, WAN Qing. Dual-gate IGZO-based Neuromorphic Transistors with Stacked Al₂O₃/Chitosan Gate Dielectrics [J]. Journal of Inorganic Materials, 2023, 38(4): 445-451.
[12]	LI Yicun, LIU Xuedong, HAO Xiaobin, DAI Bing, LYU Jilei, ZHU Jiaqi. Rapid Growth of Single Crystal Diamond at High Energy Density by Plasma Focusing [J]. Journal of Inorganic Materials, 2023, 38(3): 303-309.
[13]	WANG Donghai, LI Dongzhen, XU Jun. An Important Breakthrough in the Technology of Sapphire Plate with Large Size Grown by the Edge-defined Film-fed Growth Method [J]. Journal of Inorganic Materials, 2023, 38(3): 363-364.
[14]	LI Yicun, HAO Xiaobin, DAI Bing, WEN Dongyue, ZHU Jiaqi, GENG Fangjuan, YUE Weiping, LIN Weiqun. Optimization Design of MPCVD Single Crystal Diamond Growth Based on Plasma Diagnostics [J]. Journal of Inorganic Materials, 2023, 38(12): 1405-1412.
[15]	CHAN Siyi, TU Juping, HUANG Ke, SHAO Siwu, YANG Zhiliang, LIU Peng, LIU Jinlong, CHEN Liangxian, WEI Junjun, AN Kang, ZHENG Yuting, LI Chengming. Uniform Growth of Two-inch MPCVD Optical Grade Diamond Film [J]. Journal of Inorganic Materials, 2023, 38(12): 1413-1419.