Preparation and Characterization of Nano-hydroxyapatite/PLGA Composites with Novel Surface-modified Nano-hydroxyapatite

doi:10.3724/SP.J.1077.2013.12502

Abstract

Abstract: Nano-hydroxyapatite (n-HA) was modified by a new method of combining silane coupling reagent (KH550) with surface-grafting L-lactide LLA. Then, the surface-modified n-HA (g-n-HA) was introduced into poly(lactic-co-glycolic acid) (PLGA) to prepare a series of g-n-HA/PLGA composites with the concentration of 3wt%, 10wt%, 20wt% and 30wt%. The properties of the g-n-HA/PLGA composites were characterized and compared with PLGA and n-HA/PLGA composites. The results show that n-HA is successfully modified by KH550 and L-LA. The g-n-HA particles could disperse more uniformly in PLGA matrix and promote PLGA to crystallize. The obtained g-n-HA/PLGA composites has better mechanical properties than those of n-HA/PLGA composites with the same amount of n-HA. Moreover, the bending and tensile strength of g-n-HA/PLGA composite containing 10wt% g-n-HA are 14.4% and 11.3% which is higher than that of pure PLGA, respectively. Therefore, the g-n-HA/PLGA composite is promising for bone fracture internal fixation material in future.

Key words: nano-hydroxyapatite (n-HA), surface modification, composite, PLGA

CLC Number:

R318

JIANG Li-Xin, JIANG Liu-Yun, MA Chi, HAN Chong-Tao, XU Li-Juan, XIONG Cheng-Dong. Preparation and Characterization of Nano-hydroxyapatite/PLGA Composites with Novel Surface-modified Nano-hydroxyapatite[J]. Journal of Inorganic Materials, 2013, 28(7): 751-756.

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