生物陶瓷骨骼模型的制作

doi:10.3724/SP.J.1077.2012.00348

摘要/Abstract

摘要：

目前商用快速成型机的制备工艺参数与原料都受到限制, 不易制作骨骼模型, 为克服上述缺点, 使用自行开发的快速成型机制作骨骼模型. 本研究主要是以羟基磷灰石、二氧化硅溶胶和少许分散剂混合之浆料为原料, 经由适当的调整加工参数后, 可成型生物陶瓷生胚. 生胚试片分别在1200℃、1300℃、1400℃烧结, 并对其体积收缩率、表面粗糙度和抗压强度进行分析. 经由培养MG63类骨母细胞, 研究骨骼模型表面的细胞活性. 结果显示, 生胚在1200℃烧结时性能较佳, 抗压强度明显上升, 表面粗糙度R_a为12.04 μm, 较适合MG63类骨母細胞生长.

关键词: 生物陶瓷, 骨骼模型, 快速成形, 激光

Abstract:

The process parameters and raw materials of current commercial rapid prototyping (RP) machines are limited, thus the bone model is not easily to fabricate. In order to overcome these disadvantages, a self-developed rapid prototyping machine was used to produce bone model. In this work, the hydroxyapatite (HA), silica sol and suspending agent were mixed as raw materials. By adjusting the suitable process parameter, the bio-ceramic green parts could be formed, and then the specimen green parts were sintered at 1200℃, 1300℃, 1400℃, respectively. The shrinkage, surface roughness and compression strength were tested. Furthermore, the cell activities of the bone model were investigated through the osteoblast MG63 cells culture. The results showed that the green part sintered at 1200℃ exhibits optimum properties with greatly improved compression strength and surface roughness of R_a (12.04 μm), which is suitable for the growth of the osteoblast MG63.

Key words: bio-ceramic, bone model, rapid prototyping, laser

中图分类号:

TQ174

刘福兴, 陈思翰. 生物陶瓷骨骼模型的制作[J]. 无机材料学报, 2012, 27(4): 348-352.

LIU Fwu-Hsing, CHEN Ssu-Han. Fabrication of Bio-ceramic Bone Model[J]. Journal of Inorganic Materials, 2012, 27(4): 348-352.

图/表 7

图1 选择性激光固化法快速成型机

Fig. 1 A rapid prototyping machine of selective laser curing

图2 实验流程示意图

Fig. 2 Schematic of the experimental processes

图3 可成型区域图

Fig. 3 Forming range of the selective laser curing

图4 股骨骨骼模型成品图

Fig. 4 A finished part of femur bone model

图5 股骨骨骼模型表面微观结构SEM照片

Fig. 5 SEM surface image of femur bone model

图6 试片烧结温度与体积收缩率(a), 表面粗糙度(b)和抗压强度(c)的关系

Fig. 6 Effect of sintering temperatures on the shrinkage (a), surface roughness (b) and compression strength (c) of specimen

图7 类骨母细胞在不同培养时间下细胞光密度值

Fig. 7 Optical density of osteoblasts cells cultured for different times

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