硫酸钙骨水泥中硅酸二钙与HPMC协同优化强度与可注射性

doi:10.15541/jim20260101

摘要/Abstract

摘要： 为克服传统硫酸钙骨水泥机械强度不足的临床局限,本研究采用硅酸二钙（C₂S）和羟丙基甲基纤维素（HPMC）改性处理,开发了一种基于硫酸钙半水合物（CSH）的新型复合骨水泥。通过一系列综合表征揭示了其增强机制：C₂S通过填充孔隙并调控CSH水化过程来发挥增强相作用,HPMC通过调节水化动力学及形成氢键与配位复合物进而协同优化复合骨水泥的微观结构。在最佳质量浓度1.5% C₂S和1.0% HPMC下,复合骨水泥的抗压强度达到(21.35±1.36) MPa,比纯CSH (6.46±1.46) MPa提高了3.3倍。此外,可注射性由30.23%显著提升至89.32%,同时凝固时间得到优化。体外评估显示其降解曲线稳定且呈中性pH环境,实现了降解速率与结构稳定性的良好平衡。溶血和细胞毒性检测证实其具有优异的生物相容性,未观察到生物毒性。该改性复合骨水泥兼具卓越的力学性能、优异的可注射性、可控的降解特性及良好的生物相容性,展现出广阔的临床应用前景。

关键词: 硫酸钙半水合物, 硅酸二钙, 羟丙基甲基纤维素(HPMC), 协同修饰, 力学性能, 生物相容性

Abstract: To overcome the clinical limitations of insufficient mechanical strength in traditional calcium sulfate bone cements, in this study, a novel composite bone cement based on calcium sulfate hemihydrate (CSH) modified with dicalcium silicate (C₂S) and hydroxypropyl methylcellulose (HPMC) was developed. Comprehensive characterization reveals the underlying reinforcement mechanism: C₂S acts as a reinforcing phase by filling voids and regulating CSH hydration, while HPMC synergistically optimizes the microstructure by modulating hydration kinetics and forming hydrogen bonds and coordination complexes. At optimal concentrations of 1.5% (in mass) C₂S and 1.0% (in mass) HPMC, the compressive strength of the composite reached (21.35±1.36) MPa, a 3.3-fold increase compared to (6.46±1.46) MPa for pure CSH. Furthermore, injectability was significantly enhanced from 30.23% to 89.32%, and the setting time was also adjusted to a clinically suitable range. In vitro assessments demonstrated stable degradation profiles and a neutral pH environment, achieving a favorable balance between degradation rate and structural stability. Hemolysis and cytotoxicity assays confirmed excellent biocompatibility with no observed biotoxicity. In summary, this modified composite bone cement synergistically combines superior mechanical properties, excellent injectability, controlled degradation and robust biocompatibility, showing great potential for clinical application.

Key words: calcium sulfate hemihydrate, dicalcium silicate, hydroxypropyl methylcellulose (HPMC), synergistic modification, mechanical property, biocompatibility

中图分类号:

TB34
R318

韩佳莹, 许英德, 崔振铎, 朱胜利, 梁砚琴, 姜辉, 高忠辉, 徐文策, 李朝阳. 硫酸钙骨水泥中硅酸二钙与HPMC协同优化强度与可注射性[J]. 无机材料学报, DOI: 10.15541/jim20260101.

HAN Jiaying, XU Yingde, CUI Zhenduo, ZHU Shengli, LIANG Yanqin, JIANG Hui, GAO Zhonghui, XU Wence, LI Zhaoyang. Synergistic Optimization of Dicalcium Silicate and HPMC for Enhanced Calcium Sulfate Cement Strength and Injectability[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20260101.

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