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无机材料学报

• 研究论文 •    

Ti3C2Tx压电复合水凝胶用于感染创面修复研究

聂晓双1,2, 李丹丹1, 王芳1,2, 欧阳丽萍3, 李恒1, 邱家军1   

  1. 1.中国科学院上海硅酸盐研究所 关键陶瓷材料全国重点实验室,上海 200050;
    2.中国科学院大学 材料科学与光电工程中心,北京 100049;
    3.上海交通大学医学机器人研究所 同仁医院柔性医疗机器人上海市重点实验室,上海 200336
  • 收稿日期:2025-04-27 修回日期:2025-05-19
  • 作者简介:聂晓双(2000-),女,硕士研究生. E-mail: niexiaoshuang0908@163.com
  • 基金资助:
    国家重点研发计划(2022YFC2403000); 上海市科学技术委员会(24CL2900700); 中国科学院青年创新促进会(2023263); 横店集团控股有限公司(SHXHZDXK202302); 徐汇区医学重点学科(SHXHZDXK202302)

Ti3C2Tx Piezoelectric Composite Hydrogels for Bacterial-infected Skin Wound Healing

NIE Xiaoshuang1,2, LI Dandan1, WANG Fang1,2, OUYANG Liping3, LI Heng1, QIU Jiajun1   

  1. 1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China;
    2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China;
    3. Shanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200336, China
  • Received:2025-04-27 Revised:2025-05-19
  • About author:NIE Xiaoshuang (2000-), female, Master candidate. E-mail: niexiaoshuang0908@163.com
  • Supported by:
    National Key Research and Development Program of China (2022YFC2403000); Science and Technology Commission of Shanghai Municipality (24CL2900700); Youth Innovation Promotion Association CAS (2023263); Hengdian Group Holding Co. LTD; Medical Key Subject of Xuhui District (SHXHZDXK202302)

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摘要： 有效控制细菌感染并促进血管生成是加速感染性创面愈合面临的重要挑战。开发一种兼具抗菌和促进血管生成的多功能水凝胶创面敷料具有重要研究价值。本研究以Ti3C2Al为前驱体,采用选择性化学刻蚀法制备Ti3C2Tx MXene纳米片,并将其与可注射性聚乙烯醇(PVA)/阳离子瓜尔胶(CGG)水凝胶形成动态交联网络,构建了具有超声响应特性的PVA/CGG/MXene复合水凝胶(PCM)。实验结果表明,CGG分子链中的季铵阳离子基团通过静电相互作用显著增强了PCM水凝胶的抗菌性能,对金黄色葡萄球菌和大肠杆菌的抗菌率分别达到97.34%和95.40%。MXene纳米片赋予水凝胶稳定的导电及压电特性,在低频超声刺激下,PCM水凝胶可通过压电效应产生电信号,进而促进细胞增殖、迁移和血管再生。大鼠全层皮肤感染创面模型证实,PCM水凝胶通过抗菌、促进血管生成和胶原沉积,显著加快了创面愈合过程,10 d内创面几乎完全愈合。本工作成功开发了一种集超声响应电刺激、抗菌与促进血管再生功能于一体的多功能水凝胶敷料,为感染创面修复治疗提供了新策略。

关键词: 压电效应, Ti3C2Tx, 抗菌, 水凝胶, 创面修复

Abstract: Effective control of bacterial infection, alongside the simultaneous promotion of angiogenesis, represents a significant challenge for accelerating the healing of infected wounds. The development of a multifunctional hydrogel wound dressing with both antibacterial and angiogenesis-promoting functions is of great research value. In this study, Ti3C2Al was used as the precursor, and Ti3C2Tx MXene nanosheets were prepared by selective chemical etching. These nanosheets were then integrated into a dynamic crosslinking network of injectable poly(vinyl alcohol) (PVA)/cationic guar gum (CGG) hydrogel to construct a PVA/CGG/MXene composite hydrogel (PCM) with ultrasound response properties. Experimental results showed that the quaternary ammonium cationic group in the CGG molecular chain significantly enhanced the antibacterial performance of the PCM hydrogel through electrostatic effect, and the antibacterial rates against S. aureus and E. coli reached 97.34% and 95.40%, respectively. The MXene nanosheets endowed the PCM hydrogel with stable electrical conductivity and piezoelectric properties, and under low-frequency ultrasound stimulation, the PCM hydrogel could generate an electrical signal, which in turn promoted cell proliferation, migration and vascular regeneration. The rat whole-layer skin infection wound model confirmed that PCM hydrogel significantly accelerated the wound healing process by increasing antibacterial, promoting angiogenesis and collagen deposition, and the wound was almost completely healed within 10 d. This study presents a smart hydrogel dressing that integrates ultrasound-responsive electrical stimulation, antibacterial and angiogenesis-promoting, offering an innovative new therapeutic strategy for the repair of infected wounds.

Key words: piezoelectric, Ti3C2Tx, antibacterial, hydrogel, wound healing

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