Progresses on Hollow Periodic Mesoporous Organosilicas: Preparation and Application in Tumor Therapy

doi:10.15541/jim20220435

Abstract

Abstract:

With the development of mesoporous materials and biomedicine, hollow periodic mesoporous organosilicas (HPMOs), as a new type of mesoporous silicon material, stands out among many mesoporous materials because of its high specific surface area, high drug loading, good biocompatibility, multifunctional organic-inorganic hybrid framework, low cytotoxicity and biodegradability. Drug delivery systems based on HPMOs have been continuously developed, it provides a new strategy for tumor treatment. This article summarized the synthetic progress of HPMOs in recent years, briefly introduced the types of HPMOs, mainly expounded the hard template method, liquid interface assembly method and interface recombination-transformation method, and summarized its application in tumor therapy. Finally, challenges and future development trends as a drug carrier were prospected, in order to provide reference for the preparation and application of HPMOs in tumor therapy.

Key words: hollow periodic mesoporous organosilicas, hard template method, liquid-interface assembly method, interfacial recombination-transformation method, tumor therapy, review

CLC Number:

TB34

ZHANG Wenjun, ZHAO Xueying, LÜ Jiangwei, QU Youpeng. Progresses on Hollow Periodic Mesoporous Organosilicas: Preparation and Application in Tumor Therapy[J]. Journal of Inorganic Materials, 2022, 37(11): 1192-1202.

Figures/Tables 10

References 77

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		Hard-core templating method	Liquid-interface assembly method	Interfacial reassembly and transformation method
Synthesis strategy	Difference	①Using solid particles as template ②Etchant required	①Using droplets or micelles as templates ②No etchant required	①No sacrificial template required ②No etchant required
Synthesis strategy	Similarity	The surfactant was extracted by HCl/EtOH solution
Influence factor		①Amount and type of etchant ②Etching temperature ③SNs size and organosilicon source concentration	Stability of droplets or micelles	Hydrothermal time and temperature
Advantages		Easy to control cavity diameter	①No sacrificial template required ②No etchant required ③Simple operation	①No sacrificial template required ②No etchant required
Disadvantages		①High costs ②Cumbersome operation ③Some of etchants are toxic	①Stability of droplets or micelles should be considered	High temperature of hydrothermal process

		Hard-core templating method	Liquid-interface assembly method	Interfacial reassembly and transformation method
Synthesis strategy	Difference	①Using solid particles as template ②Etchant required	①Using droplets or micelles as templates ②No etchant required	①No sacrificial template required ②No etchant required
Synthesis strategy	Similarity	The surfactant was extracted by HCl/EtOH solution
Influence factor		①Amount and type of etchant ②Etching temperature ③SNs size and organosilicon source concentration	Stability of droplets or micelles	Hydrothermal time and temperature
Advantages		Easy to control cavity diameter	①No sacrificial template required ②No etchant required ③Simple operation	①No sacrificial template required ②No etchant required
Disadvantages		①High costs ②Cumbersome operation ③Some of etchants are toxic	①Stability of droplets or micelles should be considered	High temperature of hydrothermal process