Progress of Precision Nanomedicine-mediated Gas Therapy

doi:10.15541/jim20170529

Abstract

Abstract:

The precision nanomedicine-mediated gas therapy as an emerging and promising therapy strategy has received increasing attention, due to its low toxicity and high efficacy. Recent studies show that the nanomedicine-mediated gas therapy can not only kill cancer cells in specific diseased sites, but also protect normal cells. This review summarizes and reviews the most recent progress of the nanomedicine-mediated gas therapy. We introduce the therapeutic effects and characteristics of the nanomedicine-mediated gas therapy firstly, and then review several main routes to realize the precision nanomedicine-mediated gas therapy, including targeted gas delivery, controlled gas release, biomedical imaging guidance-monitoring of gas therapy, multi-model combined therapy based on therapeutic gases, and so on, and finally summarize the present existing issues and the prospects of further development in the gas therapy field.

Key words: gas therapy, nanomedicine, controlled release, drug delivery, mesoporous silica, graphene, review

CLC Number:

TB381

HE Qian-Jun, CHEN Dan-Yang, FAN Ming-Jian. Progress of Precision Nanomedicine-mediated Gas Therapy[J]. Journal of Inorganic Materials, 2018, 33(8): 811-824.

Figures/Tables 11

Fig. 1 (A) NIR-responsive CO release mechanism of the MnCO-GON nanomedicine with a caged structure, (B) NIR responsive for CO release profiles of MnCO-GON, and (C) NIR-controllability of MnCO-GON for CO release[27] GON: Graphene Oxide Nanosheet

Fig. 2 (A) The sandwich structure of GO-BNN6 self-assembled by GO nanosheets and BNN6 molecules through the π-π stacking, and the mechanism of NIR-responsive NO release; (B) AFM data of GO-BNN6 and (C) NIR-controlled NO release profiles of the GO-BNN6 nanomedicine[28] BNN: bis-N-nitroso

Fig. 3 (A) Schematic illustration of the coordination-precipitation process of insoluble Me-RBS, (B) the NIR-responsive NO release mechanism of Me-RBS, (C) comparison of UV absorption behaviors of Me-RBS and (D) comparison of NO release behaviors of Me-RBS[38] RBS: Rosen Black Salt

Fig. 4 (A) The mechanism of ultrasound-responsive NO release from the rattle-structured BNN6-SPION@hMSN nanomedicine, (B) TEM image of the nanomedicine, (C) ultrasound-responsive NO release behavior of the nanomedicine and (D) ultrasound-induced cytotoxicity of the nanomedicine[41] BNN: bis-N-nitroso; SPION: Superparamagnetic Iron Oxide-encapsulated; hMSN: hollow Mesoporous Silica Nanoparticles

Fig. 5 (A) The mechanism of X-ray responsive NO release from the PEG-USMSs-SNO nanomedicine with the core-shell structure, (B) TEM images and elementary mapping of the nanomedicine, (C) X-ray controlled NO release behavior of the nanomedicine in vitro, and (D) X-ray controlled NO release behavior of the nanomedicine on zebrafish[42] USMSs: Upconversion nano-theranostic system; SNO: S-nitrosothiol.

Fig. 6 (A) The H2O2-triggered CO release mechanism of the MnCO@hMSN nanomedicine constructed by hMSN and manganese carbonyl prodrug, (B) TEM image and elementary mapping of the nanomedicine, (C) H2O2-triggered CO release behavior of the nanomedicine in vitro, (D) comparison of H2O2 levels in various cells and (E) comparison of cytotoxicity against various cells[43]hMSN: hollow Mesoporous Silica Nanoparticles

Fig. 7 (A) Construction and SEM image of the Arg@hMON-GOx nanomedicine based on the hMON carrier and the Arginie/GOx prodrugs, and the mechanism of glucose-responsive release of NO, (B) effects of glucose concentration on hydrogen peroxide concentration, pH and NO concentration, and (C) in vivo outcome of gas therapy by nanomedicine[44]hMON: hollow Mesoporous Organosilica Nanoparticle

Fig. 8 (A) The construction of the MSN-CaP-NO nanomedicine and its controlled NO release mechanism, (B) acid-responsive NO release behavior of the nanomedicine, and (C) light-controlled NO release profile of the nanomedicine[32]MSN: Mesoporous Silica Nanoparticles

Fig. 9 (A) The MRI-guided ultrasound-triggered NO release mechanism of BNN6-SPION@hMSN nanomedicine, and (B) tumor-targeting property and the corresponding MRI profile[41]BNN: bis-N-nitroso; SPION: Superparamagnetic Iron Oxide-encapsulated; hMSN: hollow Mesoporous Silica Nanoparticles

Fig. 10 (A) The construction of the RuNO@TiO2NPs nanomedicine and its light-controlled ROS/NO co-release mechanism, (B) behavior of light-responsive release of NO and (C) cytotoxicity profile of the nanmedicine[48]

Fig. 11 (A) The mechanism of light-controlled multidrug co-release from the mPEG-BNN6-DOX nanomedicine, (B) behavior of UV-controlled NO release of the nanomedicine, and (C) cytotobxicity profile of the nanomedicine[31]BNN: bis-N-nitroso; DOX: Doxorubicin

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