Microwave-assisted Solvothermal Synthesis of Calcium Phosphate Microspheres and Polyhedra

doi:10.3724/SP.J.1077.2014.14148

Abstract

Abstract:

Synthetic calcium phosphate (CaP) has been investigated as promising biomaterial due to its excellent biocompatibility. CaP nanosheet-assembled microspheres were prepared using Ca(CH₃COO)₂, NaH₂PO₄•2H₂O and PLA-mPEG in aqueous solution by microwave-assisted hydrothermal method at 120℃ for 30 min. Meanwhile, CaP polyhedral were prepared using Ca(CH₃COO)₂, NaH₂PO₄•2H₂O and PLA-mPEG in mixed solvent of water and ethylene glycol (EG) by microwave-assisted solvothermal method at 120℃ for 30 min. The products were characterized with X-ray powder diffraction (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM) and thermogravimetric analysis (TG). EG showed a significant effect on the chemical composition and morphology of the product. The hemoglobin protein adsorption properties of the as-prepared products were investigated. The Hb adsorption amount increased with increasing Hb initial concentration, and were decreased with increasing volume of EG.

Key words: biomaterials, calcium phosphate, microwave, self-assembling, protein adsorption

CLC Number:

TQ174

CHEN Feng, SUN Tuan-Wei, QI Chao, WU Jin, CUI Da-Xiang, ZHU Ying-Jie. Microwave-assisted Solvothermal Synthesis of Calcium Phosphate Microspheres and Polyhedra[J]. Journal of Inorganic Materials, 2014, 29(7): 776-780.

Figures/Tables 6

Fig. 1 SEM images of CaP products prepared using Ca (CH3COO)2, NaH2PO4•2H2O and PLA-mPEG in mixed solvent of water and EG by the microwave-assisted solvothermal method at 120℃ for 30 min The volume of EG: (a,b) 0 mL; (c,d) 10 mL; (e,f) 15 mL; (g,h) 20 mL

Fig. 2 TEM micrographs (a)-(d) of the CaP products prepared using Ca(CH3COO)2, NaH2PO4•2H2O and PLA-mPEG in mixed solvent of water and EG by the microwave-assisted solvothermal method at 120℃ for 30 min The volume of EG: (a) 0 mL; (b) 10 mL; (c) 15 mL; (d) 20 mL

Fig. 3 Schematic illustration of the formation process of the CaP microspheres and polyhedra by the microwave-assisted hydrothermal/solvothermal methods

Fig. 4 XRD patterns (a) and FTIR spectra (b) of the products prepared using Ca(CH3COO)2, NaH2PO4•2H2O and PLA-mPEG in mixed solvent of water and EG with different volumes of EG by the microwave-assisted solvothermal method at 120℃ for 30 min

Fig. 5 TG curves of the products prepared using Ca (CH3COO)2, NaH2PO4•2H2O and PLA-mPEG in mixed solvent of water and EG with different volumes of EG by the microwave-assisted solvothermal method at 120℃ for 30 min

Fig. 6 Hb protein adsorption properties of the products prepared using Ca(CH3COO)2, NaH2PO4•2H2O and PLA-mPEG in mixed solvent of water and EG with different volumes of EG by the microwave-assisted solvothermal method at 120℃ for 30 min

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