Preparation and Properties of Supermagnetic Calcium Phosphate Composite Scaffold

doi:10.3724/SP.J.1077.2013.12107

Abstract

Abstract:

Supermagnetic calcium phosphate composite scaffold was fabricated by merging the superparamagnetic iron oxide (SPIO) into the calcium phosphate scaffold, and then sintered in vacuum. Properties of the obtained magnetic scaffold were investigated by SEM, EDS, XRD and VSM. The stability of magnetic scaffold in water was assessed and Ros17/2.8 cells were cultured on the samples to evaluate the cell adhesion on the scaffold. The results demonstrated that the magnetic scaffold had a porous structure. The magnetic nanoparticles were uniformly distributed and firmly merged into the matrix. The content of magnetic nanoparticles could be accurately tuned, and the magnetic scaffold is stable in water. The composite scaffold maintained excellent magnetic properties, as the vacuum sintering procedure avoided the oxidation and phase transition of the magnetic nanoparticles. It is proposed that the magnetic materials might be a kind of potential bone tissue engineering scaffold in the future.

Key words: vacuum sintering, superparamagnetic iron oxide, calcium phosphate, tissue engineering scaffold, biocompatibility

CLC Number:

R318

ZENG Xiao-Bo, HU Hao, XIE Li-Qin, LAN Fang, WU Yao, GU Zhong-Wei. Preparation and Properties of Supermagnetic Calcium Phosphate Composite Scaffold[J]. Journal of Inorganic Materials, 2013, 28(1): 79-84.

Figures/Tables 7

Table1 Types of magnetic scaffolds of calcium phosphate with SPIO

Name of scaffold	Type of SPIO	Mass ratio of SPIO/HA
HA	—	—
MHA0	SPIO-h	2:100
MHA1	SPIO-h	5:100
MHA2	SPIO-h	2:100
MHA3	SPIO-h	1:100
MHA4	SPIO-c	10:100
MHA5	SPIO-c	5:100
MHA6	SPIO-c	2:100

Fig. 1 SEM images of MHA1 (a, d, g), MHA4 (b, e, h) and HA (c, f, i)

Fig. 2 SEM image (a) and EDS pattern (b) of MHA4

Table 2 Fe content and Ca/P ratio of magnetic scaffolds

Name of scaffold	Theoretical content of Fe/%	Actual content of Fe /%	Theoretical Ca/P ratio	Actual Ca/P ratio
HA	Null	0	1.67	1.679
MHA0	0.85	2.87	1.67	1.658
MHA1	2.07	2.09	1.67	1.615
MHA2	0.85	0.83	1.67	1.697
MHA3	0.43	0.51	1.67	1.673
MHA4	6.58	6.60	1.67	1.676
MHA5	3.44	3.41	1.67	1.680
MHA6	1.42	1.44	1.67	1.684

Fig. 3 XRD patterns of MHA1, MHA4, HA and HA-p (HA powder before sintered)

Fig. 4 Magnetization curves of MHA1 after sintered in vacuum (a), MHA1 after sintered in air (b), MHA1 before sintered (c) and HA after sintered in vacuum (d)

Fig. 5 SEM micrographs of Ros17/2.8 cells grown on MHA1 (a, d), MHA5 (b, e) and HA (c, f)

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