Research on Calcium Phosphate Cement Bone Adhesive

doi:10.3724/SP.J.1077.2013.12318

Abstract

Abstract:

Using citric acid and chitosan as hardening liquid, and calcium phosphate cement (CPC) as powder, gum-like adhesive bone cement is obtained after mixing the powder and liquid components together, which can be used as calcium phosphate cement bone adhesive (CPCBA). The effect of citric acid concentration on compressive strength, setting time and hydration products were investigated. In vitro cytocompatibility of the cements was also researched through cell culture on the cement surface. The results show that setting time is shorten and anti-washout is improved by introducing citric acid. Cohesion strength increases owing to chitosan chelated with calcium ion of CPC. The cements are transformed to hydroxyapatite after incubation 3 d in SBF and osteoblasts (MC3T3-E1) can attach and proliferate on the surface. Results indicate that the calcium phosphate cement bone adhesive is a suitable adhesive material for comminuted fracture.

Key words: calcium phosphate, bone adhesive, bone defect, solidification

CLC Number:

R318

YANG Sheng-Bing, WANG Jing, LIU Chang-Sheng. Research on Calcium Phosphate Cement Bone Adhesive[J]. Journal of Inorganic Materials, 2013, 28(1): 85-90.

Figures/Tables 10

Fig. 1 Schematic illustration of cohesion test

Fig. 2 Effect of citric acid concentration on compressive strength of CPCBA

Fig. 3 Effect of citric acid concentration on antiwashout

Fig. 4 Effect of citric acid concentration on washout

Fig. 5 Effect of citric acid concentration on setting time of CPCBA

Fig. 6 XRD patterns of CPCBA with different citric acid concentration

Fig. 7 Gum-like adhesive bone cement

Fig. 8 Cohesion strength of CPCBA with different citric acid concentration

Fig. 9 Schematic illustration of Ca2+ complex with CS

Fig . 10 SEM image of osteoblast (MC3T3-E1) cultured for 12 h on the CPCBA surface with 40% citric acid

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