Assembly and Release Behavior of Allopurinol Intercalated Zn/Al-NO3-LDH Composite

doi:10.3724/SP.J.1077.2011.01293

Abstract

Abstract: Allopurinot intercalated Zn/Al-NO₃-LDH composite materials were prepared by coprecipitation and ion exchange methods. It was found by XRD, FT-IR and TG-DTA analysis that allopurinol were intercalated into the LDH layers and formed a supramolecular structure in the reaction with laminate. The structure could improved allopurinol acid resistance and thermal stability. The allopurinol intercalated LDH preparaed by coprecipitation method has an excellent sustained-release performance. It was supposed that the intercalation capacity of organic molecules was increased by a Sol-Gel intermediate which was easy for the objects to be ion-exchanged and embedded during the organic molecules intercalating into the LDH layers by coprecipitation method.

Key words: allopurinol, LDH, intercalating assembly, composite, sustained-release

CLC Number:

TQ426

DU Bao-Zhong, TAI Wei, LUO Wei, PENG Zhen-Guo. Assembly and Release Behavior of Allopurinol Intercalated Zn/Al-NO₃-LDH Composite[J]. Journal of Inorganic Materials, 2011, 26(12): 1293-1298.

References

[1] 王亮, 孟祥举, 肖丰收(WANG Liang, et al). 水滑石负载Au纳米粒子的制备及其催化醇氧化反应. 催化学报(Chinese J. Catal.), 2010, 31(8): 943-947.

[2] 雷立旭, 张卫锋, 胡猛(LEI Li-Xu, et al)．层状复合金属氢氧化物: 结构、性质及其应用．无机化学学报(Chinese J. Inorg. Chem.), 2005, 21(4): 451-463.

[3] Koch Chr Bender. Structures and properties of anionic clay minerals. Hyperfine Interactions, 1998, 117(1-4): 171-176.

[4] Evans D G, Xue Duan. Preparation of layered doublehydroxides and their applications as additives in poly-mers, as precursors to magnetic materials and in biologyand medicine. Chem. Commun., 2006, 7(5): 485-496.

[5] 彭霞辉, 黄克龙, 焦飞鹏, 等. 水滑石作为药物载体萘普生的插层和缓释. 功能材料, 2006, 36(3): 415-417.

[6] 吴祥根, 朱建芬, 高永良. 新型医药用载体—层状双金属氢氧化物. 中国药学杂志, 2006, 41(5): 326-329.

[7] Gasser M S. Inorganic layered double hydroxidesas ascorbic acid (vitamin C) delivery system-interca-lationand their controlled release properties. Colloids and Surfaces B: Biointerfaces, 2009, 73:103-109.

[8] 贺新. 别嘌醇的合成和应用研究. 中国现代药物应用, 2008, 4(7): 98-99.

[9] Martindale. The Extro Pharmacopoeia. British: 32ed. The Royal Pharmaoeutical Society, 1999: 390.

[10] Khan A I, O'Hare D. Intercalation chemistry of layered double hydroxides: recent developments and applications. J. Mater. Chem., 2002, 12: 3191-3198.

[11] Newman S P, Jones W. Synthesis, characterization and applications of layered double hydroxides containing organic guests. New J. Chem., 1998, 22(2): 105-115.

[12] 赵保军. 几种阴离子对羟基铝溶液及交联蒙脱石性能的研究. 北京: 北京大学硕士论文, 2002: 26-28.

[13] Lopez T, Bosh P, Ramos E. Synthesis and characterization of Sol-Gel hydrotalcites structure and texture. Langmuir, 1996, 12(1): 189-192.

[14] Bhaskar R, Murthy S, Miglani B D, et al. Novel method to evaluate diffusion controlled release of drug from resinate. Int. J. Pharm., 1986, 28(1): 59-66.

[1]	LIU Pengdong, WANG Zhen, LIU Yongfeng, WEN Guangwu. Research Progress on the Application of Silicon Slurry in Lithium-ion Batteries [J]. Journal of Inorganic Materials, 2024, 39(9): 992-1004.
[2]	QUAN Wenxin, YU Yiping, FANG Bing, LI Wei, WANG Song. Oxidation Behavior and Meso-macro Model of Tubular C/SiC Composites in High-temperature Environment [J]. Journal of Inorganic Materials, 2024, 39(8): 920-928.
[3]	MA Binbin, ZHONG Wanling, HAN Jian, CHEN Liangyu, SUN Jingjing, LEI Caixia. ZIF-8/TiO₂ Composite Mesocrystals: Preparation and Photocatalytic Activity [J]. Journal of Inorganic Materials, 2024, 39(8): 937-944.
[4]	HE Sizhe, WANG Junzhou, ZHANG Yong, FEI Jiawei, WU Aimin, CHEN Yifeng, LI Qiang, ZHOU Sheng, HUANG Hao. Fe/Submicron FeNi Soft Magnetic Composites with High Working Frequency and Low Loss [J]. Journal of Inorganic Materials, 2024, 39(8): 871-878.
[5]	WU Xiangquan, TENG Jiachen, JI Xiangxu, HAO Yubo, ZHANG Zhongming, XU Chunjie. Textured Porous Al₂O₃-SiO₂ Composite Ceramic Platelet-sphere Slurry: Characteristics and Simulation of Light Intensity Distribution [J]. Journal of Inorganic Materials, 2024, 39(7): 769-778.
[6]	SUN Haiyang, JI Wei, WANG Weimin, FU Zhengyi. Design, Fabrication and Properties of Periodic Ordered Structural Composites with TiB-Ti Units [J]. Journal of Inorganic Materials, 2024, 39(6): 662-670.
[7]	WU Xiaochen, ZHENG Ruixiao, LI Lu, MA Haolin, ZHAO Peihang, MA Chaoli. Research Progress on In-situ Monitoring of Damage Behavior of SiC_f/SiC Ceramic Matrix Composites at High Temperature Environments [J]. Journal of Inorganic Materials, 2024, 39(6): 609-622.
[8]	SU Yi, SHI Yangfan, JIA Chenglan, CHI Pengtao, GAO Yang, MA Qingsong, CHEN Sian. Microstructure and Properties of C/HfC-SiC Composites Prepared by Slurry Impregnation Assisted Precursor Infiltration Pyrolysis [J]. Journal of Inorganic Materials, 2024, 39(6): 726-732.
[9]	ZHAO Rida, TANG Sufang. Research Progress of Ceramic Matrix Composites Prepared by Improved Reactive Melt Infiltration through Ceramization of Porous Carbon Matrix [J]. Journal of Inorganic Materials, 2024, 39(6): 623-633.
[10]	FANG Guangwu, XIE Haoyuan, ZHANG Huajun, GAO Xiguang, SONG Yingdong. Progress of Damage Coupling Mechanism and Integrated Design Method for CMC-EBC [J]. Journal of Inorganic Materials, 2024, 39(6): 647-661.
[11]	ZHANG Xinghong, WANG Yiming, CHENG Yuan, DONG Shun, HU Ping. Research Progress on Ultra-high Temperature Ceramic Composites [J]. Journal of Inorganic Materials, 2024, 39(6): 571-590.
[12]	LI Guangyu, YUE Yifan, WANG Bo, ZHANG Chengyu, SUO Tao, LI Yulong. Damage of 2D-SiC/SiC Composites under Projectile Impact and Tensile Properties after Impact [J]. Journal of Inorganic Materials, 2024, 39(5): 494-500.
[13]	XUE Yifan, LI Weijie, ZHANG Zhongwei, PANG Xu, LIU Yu. Process Control of PyC Interphases Microstructure and Uniformity in Carbon Fiber Cloth [J]. Journal of Inorganic Materials, 2024, 39(4): 399-408.
[14]	GUAN Haoyang, ZHANG Li, JING Kaikai, SHI Weigang, WANG Jing, LI Mei, LIU Yongsheng, ZHANG Chengyu. Interfacial Mechanical Properties of the Domestic 3rd Generation 2.5D SiC_f/SiC Composite [J]. Journal of Inorganic Materials, 2024, 39(3): 259-266.
[15]	CHEN Zhengpeng, JIN Fangjun, LI Mingfei, DONG Jiangbo, XU Renci, XU Hanzhao, XIONG Kai, RAO Muming, CHEN Chuangting, LI Xiaowei, LING Yihan. Double Perovskite Sr₂CoFeO₅₊_δ: Preparation and Performance as Cathode Material for Intermediate-temperature Solid Oxide Fuel Cells [J]. Journal of Inorganic Materials, 2024, 39(3): 337-344.

Assembly and Release Behavior of Allopurinol Intercalated Zn/Al-NO₃-LDH Composite

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments