Borate Bioglass Based Drug Delivery of Teicoplanin for Treating Osteomyelitis

doi:10.3724/SP.J.1077.2010.00293

Abstract

Abstract: A drug delivery system which contains antibiotics for treating osteomyelitis based on a borate bioactive glass was developed. The system was consisted of the borate bioactive glass6Na₂O-8K₂O-8MgO-22CaO-54B₂O₃-2P₂O₅(mol%) as the solid phase, the solution of chitosan, critic acid and glucose as the liquid phase and carried watersoluble teicoplanin as the antibiotics. In vitro test, the drug release behavior, the mechanical properties and the biocompatibility of the drug delivery system were investigated, when the drug delivery device was immersed in phosphate buffer solution (PBS). The drug concentration in PBS were tested by HPLC(High Performance Liquid Chromatography). The drug releasing process could last as long as 30d and 72% of the drug content was released within the first week. The mechanism for the drug releasing from the devices was in accordance with Fick’s diffusion law, when the process was simulated in the Peppas model. The XRD results proved that the bioactive glass material converted into hydroapatite (HA) during the drug release process, indicating that the system had bioactivity in vitro. In vivo test on rabbits, the drug delivery system cured the osteomyelitis in tibial bone, and stimulated the regeneration of tibial bone. The above results proved that the borate bioactive glass was a suitable material for carrying antibiotics to cure osteomyelitis, and for stimulating bone regeneration.

Key words: borate glass, drug carrier, teicoplanin, kinetics, hydroxyapatite

CLC Number:

TB321

ZHANG Xin,JIA Wei-Tao,GU Yi-Fei,ZHANG Chang-Qing,HUANG Wen-Hai,WANG De-Ping. Borate Bioglass Based Drug Delivery of Teicoplanin for Treating Osteomyelitis[J]. Journal of Inorganic Materials, DOI: 10.3724/SP.J.1077.2010.00293.

References

［1］ Oliver V, Faucheux N, Hardouin P. Biomaterial challenges and approaches to stem cell use in bone reconstructive surgery. Drug Discovery Today, 2004, 9(18): 803-811.

［2］Domingues Z R, Cortes M E, Gumes T A, et al. Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin. Biomaterials, 2004, 25(2): 327-333.

［3］王德平, 黄文旵, 陈天丹(WANG De-Ping, et al). 多孔微晶玻璃作为药物载体材料的制备及其体外缓释研究. 无机材料学报(Journal of Inorganic Materials), 2001, 16(6): 1195-1198.

［4］Laurencin C T, Gerhart T, Witschger P, et al. Bioerodible polyanhydrides for antibiotic drug delivery: in vivo osteomyelitis treatment in rat model system. Journal of Orthopaedic Research, 1993, 11(2): 256-262.

［5］ Naur L S, Laurencin C T. Biodegradable polymers as biomaterials. Prog. Polym. Sci., 2007, 32(8/9): 762-798.

［6］Xie Zong-Ping, Liu Xin, Jia Wei-Tao, et al. Treatment of osteomyelitis and repair of bone defect by degradable bioactibe borate glass releasing vancomycin. Journal of Controlled Release, 2009, 139(2): 118-126.

［7］Agnihotri S A, Mallikarjuna N N, Aminabhavi T M. Recent advances on chitosanbased microand nanoparticles in drug delivery. Journal of Controlled Release, 2004, 100(1): 5-28.

［8］Zhang Yang, Zhang Miqin. Calcium phosphate/chitosan composite scaffolds for controlled in vitro antibiotic drug release. Journal of Biomedical Materials Research, 2002, 62(3): 378-386.

［9］Yokoyama A, Yamamoto S, Kawasaki T, et al. Development of calcium phosphate cement using chitosan and citric acid for bone substitute materials. Biomaterials, 2002, 23(4): 1091-1101.

［10］Lopes P P, Leite Ferreira B J M, Almeida N A F, et al. Preparation and study of in vitro bioactivity of PMMA-co-EHA composites filled with a Ca₃(PO₄)₂-SiO₂-MgO glass. Materials Science & Engineering C, 2008, 28(4): 572-577.

［11］Hamadouche M, Meunier A, Greenspan D C, et al. Long-term in-vivo bioactivity and degradability of bulk sol-gel bioactive glasses. J. Biomed. Mater. Res., 2001, 54(4): 560-566.

［12］和峰, 刘昌胜. 骨修复用生物玻璃研究进展. 玻璃与搪瓷, 2004, 32 (4): 54-58.

［13］Marion N W, Liang W, Reilly G. Borate glass supports the in vitro osteogenic differentiation of human mesenchymal stem cells. Mechanics of Advanced Materials and Structures, 2005, 12(3): 239-246.

［14］Yao Aihua, Wang Deping, Huang Wenhai. In vitro bioactive characteristics of borate based glasses with controllable degradation behavior. Journal of American Ceramic Society, 2007, 90(1): 303-306.

［15］Huang Wenhai, Rahaman M N, Day D E, et al. Mechanisms for converting bioactive silicate, borate, and borosilicate glasses to hydroxyapatite in dilute phosphate solutions. Physics and Chemistry of Glasses, 2006, 47(6): 647-658.

［16］Gbureck U, Vorndran E, Barralet J E. Modeling vancomycin release kinetics from microporous calcium phosphate ceramics comparing static and dynamic immersing conditions. Acta Biomaterial, 2008, 4(5): 14801486.

[1]	LI Chengyu, DING Ziyou, HAN Yingchao. In vitro Antibacterial and Osteogenic Properties of Manganese Doped Nano Hydroxyapatite [J]. Journal of Inorganic Materials, 2024, 39(3): 313-320.
[2]	LIU Yan, ZHANG Yufan, WANG Ximan, LI Ting, MA Wenting, YANG Fuwei, CHEN Liang, ZHAO Dongyue, YAN Xiaoqin. Consolidation of Fragile Weathered Bone Relics Using Hydroxyapatite Material as Consolidant [J]. Journal of Inorganic Materials, 2023, 38(11): 1345-1354.
[3]	PANG Libin, WANG Deping. Drug Carrier Based on Mesoporous Borosilicate Glass Microspheres: Preparation and Performance [J]. Journal of Inorganic Materials, 2022, 37(7): 780-786.
[4]	SUN Yangshan, YANG Zhihua, CAI Delong, ZHANG Zhengyi, LIU Qi, FANG Shuqing, FENG Liang, SHI Lifen, WANG Youle, JIA Dechang. Crystallization Kinetics, Properties of α-cordierite Based Glass-ceramics Prepared by Glass Powder Sintering [J]. Journal of Inorganic Materials, 2022, 37(12): 1351-1357.
[5]	CHEN Yaling, SHU Song, WANG Shaoxin, LI Jianjun. Mn-HAP SCR Catalyst: Preparation and Sulfur Resistance [J]. Journal of Inorganic Materials, 2022, 37(10): 1065-1072.
[6]	ZHU Yutong, TAN Peijie, LIN Hai, ZHU Xiangdong, ZHANG Xingdong. Injectable Hyaluronan/Hydroxyapatite Composite: Preparation, Physicochemical Property and Biocompatibility [J]. Journal of Inorganic Materials, 2021, 36(9): 981-990.
[7]	LIN Ziyang, CHANG Yuchen, WU Zhangfan, BAO Rong, LIN Wenqing, WANG Deping. Different Simulated Body Fluid on Mineralization of Borosilicate Bioactive Glass-based Bone Cement [J]. Journal of Inorganic Materials, 2021, 36(7): 745-752.
[8]	WU Zhongcao, HUAN Zhiguang, ZHU Yufang, WU Chengtie. 3D Printing and Characterization of Microsphere Hydroxyapatite Scaffolds [J]. Journal of Inorganic Materials, 2021, 36(6): 601-607.
[9]	WU Yonghao, LI Xiangfeng, ZHU Xiangdong, ZHANG Xingdong. Construction of Hydroxyapatite Nanoceramics with High Mechanical Strength and Efficiency in Promoting the Spreading and Viability of Osteoblasts [J]. Journal of Inorganic Materials, 2021, 36(5): 552-560.
[10]	SONG Keke, HUANG Hao, LU Mengjie, YANG Anchun, WENG Jie, DUAN Ke. Hydrothermal Preparation and Characterization of Zn, Si, Mg, Fe Doped Hydroxyapatite [J]. Journal of Inorganic Materials, 2021, 36(10): 1091-1096.
[11]	ZHANG Junmin, CHEN Xiaowu, LIAO Chunjin, GUO Feiyu, YANG Jinshan, ZHANG Xiangyu, DONG Shaoming. Optimizing Microstructure and Properties of SiC_f/SiC Composites Prepared by Reactive Melt Infiltration [J]. Journal of Inorganic Materials, 2021, 36(10): 1103-1110.
[12]	SHAO Yueting, ZHU Yingjie, DONG Liying, CAI Anyong. Nanocomposite “Xuan Paper” Made from Ultralong Hydroxyapatite Nanowires and Cellulose Fibers and Its Anti-mildew Properties [J]. Journal of Inorganic Materials, 2021, 36(1): 107-112.
[13]	ZHANG Xiaoxu,ZHU Dongbin,LIANG Jinsheng. Progress on Hydrothermal Stability of Dental Zirconia Ceramics [J]. Journal of Inorganic Materials, 2020, 35(7): 759-768.
[14]	SUN Tuanwei,ZHU Yingjie. One-step Solvothermal Synthesis of Strontium-doped Ultralong Hydroxyapatite Nanowires [J]. Journal of Inorganic Materials, 2020, 35(6): 724-728.
[15]	LIU Ziyang, GENG Zhen, LI Zhaoyang. Preparing Biomedical CaCO₃/HA Composite with Oyster Shell [J]. Journal of Inorganic Materials, 2020, 35(5): 601-607.