Ti3C2Tx Piezoelectric Composite Hydrogels for Bacterial-infected Skin Wound Healing

doi:10.15541/jim20250180

Abstract

Abstract: Effective control of bacterial infection, alongside the simultaneous promotion of angiogenesis, represents a significant challenge for accelerating the healing of infected wounds. The development of a multifunctional hydrogel wound dressing with both antibacterial and angiogenesis-promoting functions is of great research value. In this study, Ti₃C₂Al was used as the precursor, and Ti₃C₂T_x MXene nanosheets were prepared by selective chemical etching. These nanosheets were then integrated into a dynamic crosslinking network of injectable poly(vinyl alcohol) (PVA)/cationic guar gum (CGG) hydrogel to construct a PVA/CGG/MXene composite hydrogel (PCM) with ultrasound response properties. Experimental results showed that the quaternary ammonium cationic group in the CGG molecular chain significantly enhanced the antibacterial performance of the PCM hydrogel through electrostatic effect, and the antibacterial rates against S. aureus and E. coli reached 97.34% and 95.40%, respectively. The MXene nanosheets endowed the PCM hydrogel with stable electrical conductivity and piezoelectric properties, and under low-frequency ultrasound stimulation, the PCM hydrogel could generate an electrical signal, which in turn promoted cell proliferation, migration and vascular regeneration. The rat whole-layer skin infection wound model confirmed that PCM hydrogel significantly accelerated the wound healing process by increasing antibacterial, promoting angiogenesis and collagen deposition, and the wound was almost completely healed within 10 d. This study presents a smart hydrogel dressing that integrates ultrasound-responsive electrical stimulation, antibacterial and angiogenesis-promoting, offering an innovative new therapeutic strategy for the repair of infected wounds.

Key words: piezoelectric, Ti₃C₂T_x, antibacterial, hydrogel, wound healing

CLC Number:

R318

NIE Xiaoshuang, LI Dandan, WANG Fang, OUYANG Liping, LI Heng, QIU Jiajun. Ti₃C₂T_x Piezoelectric Composite Hydrogels for Bacterial-infected Skin Wound Healing[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250180.

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Ti₃C₂T_x Piezoelectric Composite Hydrogels for Bacterial-infected Skin Wound Healing

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