Fe掺杂Ti-MOFs用于牙周炎抗菌声动力治疗

doi:10.15541/jim20250165

无机材料学报 ›› 2026, Vol. 41 ›› Issue (4): 527-535.DOI: 10.15541/jim20250165 CSTR: 32189.14.10.15541/jim20250165

Fe掺杂Ti-MOFs用于牙周炎抗菌声动力治疗

王浩宇¹^,²(), 柯学¹^,², 关世伟¹^,², 钱仕¹^,²(), 刘宣勇¹^,²

¹ 中国科学院上海硅酸盐研究所, 关键陶瓷材料全国重点实验室, 上海 200050
² 中国科学院大学材料与光电研究中心, 北京 100049

收稿日期:2025-04-19 修回日期:2025-05-11 出版日期:2026-04-20 网络出版日期:2025-06-05
通讯作者: 钱仕, 研究员. E-mail: qianshi@mail.sic.ac.cn
作者简介:王浩宇(2000-), 男, 硕士研究生. E-mail: wanghaoyu222@mails.ucas.ac.cn

Fe Doped Ti-MOFs for Enhanced Antibacterial Sonodynamic Therapy of Periodontitis

WANG Haoyu¹^,²(), KE Xue¹^,², GUAN Shiwei¹^,², QIAN Shi¹^,²(), LIU Xuanyong¹^,²

¹ State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
² Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2025-04-19 Revised:2025-05-11 Published:2026-04-20 Online:2025-06-05
Contact: QIAN Shi, professor. E-mail: qianshi@mail.sic.ac.cn
About author:WANG Haoyu (2000-), male, Master candidate. E-mail: wanghaoyu222@mails.ucas.ac.cn
Supported by:
National Natural Science Foundation of China(52450110)

摘要/Abstract

摘要：

牙周炎是临床极富挑战的问题, 由口腔致病菌过度生长失衡引起, 可导致牙周组织的不可逆损伤。与清创术相比, 抗菌声动力疗法(aSDT)具有优异的生物相容性和组织穿透能力, 是一种有前景的替代方案。本工作制备了铁掺杂的钛基金属有机框架(Fe/Ti-MOFs), 研究了铁掺杂与声催化效率间的量效关系。引入Fe能够调节MOFs的能带结构和结晶度, 且未改变其晶格结构。结果表明, Fe/Ti-MOFs在超声作用下表现出增强的羟基自由基(•OH)产生能力, 从而催化杀灭细菌病原体。其中, Fe/Ti摩尔比为0.025 : 1的样品表现出较佳的声催化性能, 且受带隙工程、铁掺杂浓度和结晶度的共同调节。此外, 牙龈成纤维细胞增殖和活死染色结果表明, Fe/Ti-MOFs具有优异的生物相容性。超声响应的Fe/Ti-MOFs材料为牙周炎的aSDT提供了新的见解和策略, 有望避免抗生素的不良反应。

关键词: 抗菌, 声动力治疗, 牙周炎, 金属有机框架, NH₂-MIL-125(Ti)

Abstract:

Periodontitis is a clinical challenge caused by bacterial overgrowth, resulting in irreversible damage to periodontal tissue. Antibacterial sonodynamic therapy (aSDT) has emerged as a promising alternative to conventional debridement due to its excellent biocompatibility and tissue penetration capability. However, this therapy cannot cure the periodontitis solely, needing more exploration to find an effectively improved treatment. Here, Fe doped Ti based metal-organic frameworks (Fe/Ti-MOFs) were prepared to explore the relationship between Fe doping and sonoresponsive efficiency. Incorporation of Fe enabled precise modulation of the band structure and crystallinity while maintaining the lattice architecture. Results showed that Fe/Ti-MOFs exhibited enhanced hydroxyl radical (•OH) generation under ultrasonic irradiation, effectively facilitating the eradication of bacterial pathogens. Notably, the sample with a Fe/Ti molar ratio of 0.025 : 1 exhibited exceptional performance. The sonocatalytic activity was collectively influenced by bandgap engineering, Fe doping concentration and crystallinity. Moreover, Fe/Ti-MOFs exhibited no cytotoxicity toward gingival fibroblasts and maintained excellent biocompatibility, without adverse effects on tissue repair. The ultrasound responsive Fe/Ti-MOFs material developed in this study offers potential for mitigating the adverse effects of antibiotics and providing novel insights and strategies for the application of aSDT in periodontitis treatment.

Key words: antibacterial, sonodynamic therapy, periodontitis, metal organic framework, NH₂-MIL-125(Ti)

中图分类号:

R781

王浩宇, 柯学, 关世伟, 钱仕, 刘宣勇. Fe掺杂Ti-MOFs用于牙周炎抗菌声动力治疗[J]. 无机材料学报, 2026, 41(4): 527-535.

WANG Haoyu, KE Xue, GUAN Shiwei, QIAN Shi, LIU Xuanyong. Fe Doped Ti-MOFs for Enhanced Antibacterial Sonodynamic Therapy of Periodontitis[J]. Journal of Inorganic Materials, 2026, 41(4): 527-535.

图/表 12

Fig. 1 SEM images of Ti-MOFs (a1), Fe/Ti-MOFs (0.025 : 1) (a2), Fe/Ti-MOFs (0.05 : 1) (a3), and Fe/Ti-MOFs (0.1 : 1) (a4); XRD patterns (b), FT-IR spectra (c), and N2 adsorption desorption curves (d) of samples

Fig. 2 High resolution XPS spectra of Ti2p (a1-a4) and Fe2p (b1-b4) of Ti-MOFs, Fe/Ti-MOFs (0.025 : 1), Fe/Ti-MOFs (0.05 : 1), and Fe/Ti-MOFs (0.1 : 1)

Fig. 3 UV-Vis spectra (a), bandgap fitting (b), and photoelectric response (c) of Ti-MOFs, Fe/Ti-MOFs (0.025 : 1), Fe/Ti-MOFs (0.05 : 1), and Fe/Ti-MOFs (0.1 : 1)

Fig. 4 MB degradation efficiencies of samples (a), absorption curves of Fe/Ti-MOFs (0.025 : 1) before and after ultrasound at different powers (b), and ESR spectra of samples under ultrasound (c) Colorful figures are available on website

Fig. 5 Photos of re-cultivated bacterial colonies (a) and antibacterial rates against E. coli (b), S. aureus (c) and P. gingivalis (d) of Ti-MOFs, Fe/Ti-MOFs (0.025 : 1), Fe/Ti-MOFs (0.05 : 1), and Fe/Ti-MOFs (0.1 : 1) before and after ultrasonic treatment US+ and US- represent under ultrasonic and non-ultrasonic conditions, respectively. Colorful figures are available on website

Fig. 6 Live-dead staining images (a), cell proliferation (b), and hemolysis tests (c, d) of Ti-MOFs, Fe/Ti-MOFs (0.025 : 1), Fe/Ti-MOFs (0.05 : 1), and Fe/Ti-MOFs (0.1 : 1) Colorful figures are available on website

Table S1 Raw material usage in preparation process of Fe/Ti-MOFs with different Fe : Ti ratios

Sample	H₂BDC-NH₂/g	Fe(acac)₃/mg	TTIP/mL	DMF/mL	CH₃OH/mL
Ti-MOFs	2.72	0	1.15	45.0	5.00
Fe/Ti-MOFs (0.025 : 1)	2.72	33.1	1.15	45.0	5.00
Fe/Ti-MOFs (0.05 : 1)	2.72	66.1	1.15	45.0	5.00
Fe/Ti-MOFs (0.1 : 1)	2.72	132.2	1.15	45.0	5.00

Table S2 Diffraction peak parameters of different crystal planes of Ti-MOFs and different Fe/Ti-MOFs materials

Sample		Ti-MOFs	Fe/Ti-MOFs (0.025 : 1)	Fe/Ti-MOFs (0.05 : 1)	Fe/Ti-MOFs (0.1 : 1)
(101)	Intensity	1858	1405	1123	546
(101)	FWHM/°	0.196	0.192	0.238	0.317
(100)	Intensity	483	386	382	205
(100)	FWHM/°	0.160	0.147	0.164	0.174
(001)	Intensity	1885	1340	1093	631
(001)	FWHM/°	0.208	0.215	0.303	0.543
(211)	Intensity	2171	1612	1427	865
(211)	FWHM/°	0.180	0.170	0.207	0.362

Table S3 Specific surface area and pore volume data of Ti-MOFs and different Fe/Ti-MOFs

Sample	S_BET/(m²·g^-1)	S_DFT/(m²·g^-1)	V_pore/(cm³·g^-1)
Ti-MOFs	1132.08	1722.72	0.69
Fe/Ti-MOFs (0.025 : 1)	1134.90	1702.66	0.66
Fe/Ti-MOFs (0.05 : 1)	1175.66	1736.29	0.74
Fe/Ti-MOFs (0.1 : 1)	1033.73	1533.40	0.77

Fig. S1 (001) crystal plane of NH2-MIL-125(Ti) (a) and secondary building units before (b) and after (c) Fe doping

Fig. S2 Full XPS spectra (a1-d1) and high-resolution C1s (a2-d2), N1s (a3-d3), and O1s (a4-d4) XPS spectra of Ti-MOFs, Fe/Ti-MOFs (0.025 : 1), Fe/Ti-MOFs (0.05 : 1), and Fe/Ti-MOFs (0.1 : 1)

Fig. S3 Degradability evaluation of Ti-MOFs, Fe/Ti-MOFs (0.025 : 1), Fe/Ti-MOFs (0.05 : 1), and Fe/Ti-MOFs (0.1 : 1)

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Fe掺杂Ti-MOFs用于牙周炎抗菌声动力治疗

Fe Doped Ti-MOFs for Enhanced Antibacterial Sonodynamic Therapy of Periodontitis

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