骨损伤修复用硫酸钙及其无机复合材料的研究进展

doi:10.3724/SP.J.1077.2013.12758

摘要/Abstract

摘要： 创伤、骨肿瘤、关节置换术等引起骨缺损的修复是目前临床治疗的难点和研究热点领域, 寻找理想的骨修复材料已经成为该领域的重点研究方向。硫酸钙骨水泥作为骨修复材料已有百余年历史, 有着显著的优势。但其降解过快的缺点影响了治疗效果, 限制了应用范围。本文对硫酸钙的理化特性、晶粒形貌与晶型控制、合成方法等进行了系统介绍, 总结了硫酸钙与羟基磷灰石、生物玻璃、磷酸钙和硅酸钙复合材料及其性能研究的新成果, 并提出了克服硫酸钙作为骨修复材料的缺点的若干方法。

关键词: 硫酸钙, 骨水泥, 合成方法, 生物活性, 生物相容性, 无机复合材料, 综述

Abstract: Treatments of bone defects caused by trauma, tumor and arthroplasty are challenging research area which has aroused great interests among biomaterial researchers to design and fabricate ideal artificial implants. Calcium sulfate has been used as biomedical bone cement for over a century, but its too fast bioresorption limits the applications in some clinical conditions. In this paper, its physicochemical properties, crystal polymorph and synthetic techniques are summarized. Furthermore, the recent research progress on calcium sulfate-based inorganic composite with hydroxyapatite, bioactive glasses, calcium phosphate cements and calcium silicate cements are reviewed. In addition, the development perspective on overcoming the shortcomings of calcium sulfate-base biomaterials is also discussed.

Key words: calcium sulfate, bone cements, synthetic method, bioactivity, biocompatibility inorganic composite, review

中图分类号:

TQ174

杨国敬, 林勉, 张雷, 苟中入. 骨损伤修复用硫酸钙及其无机复合材料的研究进展[J]. 无机材料学报, 2013, 28(8): 795-803.

YANG Guo-Jing, LIN Mian, ZHANG Lei, GOU Zhong-Ru. Progress of Calcium Sulfate and Inorganic Composites for Bone Defect Repair[J]. Journal of Inorganic Materials, 2013, 28(8): 795-803.

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