自固化硅羟基磷灰石骨水泥的制备及性能研究

doi:10.3724/SP.J.1077.2011.00055

无机材料学报 ›› 2011, Vol. 26 ›› Issue (1): 55-60.DOI: 10.3724/SP.J.1077.2011.00055 CSTR: 32189.14.SP.J.1077.2011.00055

自固化硅羟基磷灰石骨水泥的制备及性能研究

苏佳灿, 曹烈虎, 禹宝庆, 王志伟, 陈晓, 李明

上海市第二军医大学附属长海医院骨科, 上海 200433

收稿日期:2010-04-23 修回日期:2010-09-03 出版日期:2011-01-20 网络出版日期:2010-12-23
作者简介:苏佳灿(1976-), 男, 博士, 副教授. E-mail: sujiacan@yahoo.com.cn
基金资助:
上海市科委纳米专项基金(0852nm04300); 上海市人事局人才发展资金(2009003);中国博士后基金(20100470756)

Study on Preparation and Properties of Self-setting Silicon HydroxyapatiteBone Cement

SU Jia-Can, CAO Lie-Hu, YU Bao-Qing, WANG Zhi-Wei, CHEN Xiao, LI Ming

Department of Orthopaedics,Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Received:2010-04-23 Revised:2010-09-03 Published:2011-01-20 Online:2010-12-23
Supported by:
ShanghaiNano-technology Promotion Center and the Science&Technology Committee ofShanghai Municipality (0852nm04300); Talents Project of Shanghai MunicipalPersonnel Bureau (2009003); China's Post-doctoral Science Fund (20100470756)

摘要/Abstract

摘要： 采用磷酸四钙和磷酸氢钙为羟基磷灰石水泥(HAC)粉末,5wt%硅酸钠水溶液为固化液, 制备了硅羟基磷灰石水泥(s-HAC). 结果显示: s-HAC的凝结时间和抗压强度性能明显优于以水为固化液的HAC. XRD和IR结果分析表明: s-HAC的最终水化产物为硅羟基磷灰石. s-HAC在Tris-HCl缓冲溶液中不仅能够释放出Ca、P离子,而且还能释放出Si离子, s-HAC的体外降解性优于HAC. 细胞培养实验显示: MG₆₃细胞不仅能够在s-HAC和HAC表面粘附并保持正常的细胞形态; 而且MG₆₃细胞在s-HAC上的光密度(OD)值和碱性磷酸酶(ALP)活性明显高于HAC, 这说明s-HAC能促进成骨细胞增殖和分化.

关键词: 硅羟基磷灰石, 水泥, 降解, 细胞增殖, 分化

Abstract: Siliconhydroxyapatite cement (s-HAC) was prepared by using the mixed powders oftetracalcium phosphate and dicalcium phosphate anhydrous, and 5wt% sodiumsilicate water solutions as cement liquid. The results show that the settingtime of s-HAC is shorter than hydroxyapatite cement (HAC), and the compressivestrength of s-HAC is higher than HAC in the same situation. The XRD resultsreveal that the finally hardening product of s-HAC is hydroxyapatite structure,which is similar to that of HAC. The s-HAC in the could release calcium (Ca),phosphorus (P) and silicon (Si) ions. The <>in vitro degradability of s-HACin Tris-HCl solution is better than that of HAC. The cell culture experimentalresults indicate that the cell can attach on both the surfaces of s-HAC andHAC, and have good cell morphology. The optical density (OD) and alkalinephosphate (ALP) activity of MG₆₃ cells on s-HAC are significantlyhigher that that of HAC, indicating that the s-HAC could promote the cellproliferation and differentiation.

Key words: silicon hydroxyapatite, cement, degradation, cell proliferation, differentiation

中图分类号:

TB383

苏佳灿, 曹烈虎, 禹宝庆, 王志伟, 陈晓, 李明. 自固化硅羟基磷灰石骨水泥的制备及性能研究[J]. 无机材料学报, 2011, 26(1): 55-60.

SU Jia-Can, CAO Lie-Hu, YU Bao-Qing, WANG Zhi-Wei, CHEN Xiao, LI Ming. Study on Preparation and Properties of Self-setting Silicon HydroxyapatiteBone Cement[J]. Journal of Inorganic Materials, 2011, 26(1): 55-60.

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自固化硅羟基磷灰石骨水泥的制备及性能研究

Study on Preparation and Properties of Self-setting Silicon HydroxyapatiteBone Cement

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