载不同浓度香丹注射液磷酸钙骨水泥性能研究

doi:10.3724/SP.J.1077.2010.00507

摘要/Abstract

摘要：

研究载不同浓度香丹注射液（简称香丹）磷酸钙骨水泥(CPC)的理化性能和药物释放, 为优化CPC中载入香丹浓度提供理论依据. 将香丹与CPC主要原料之一磷酸氢钙混合烘干代替磷酸氢钙制得一系列载不同浓度香丹的CPC, 香丹浓度范围在0.05～0.5mL/g. 采用Gilmore针、万能材料力学试验机、X射线衍射仪、傅立叶红外光谱仪表征载不同浓度香丹CPC的理化性能, 用扫描电镜观察微观形貌, 测定载不同浓度香丹CPC的药物释放. 结果表明CPC凝结时间随香丹浓度的增加而延长, 浓度不高于0.2mL/g的CPC样品凝结时间符合临床要求; 抗压强度随香丹含量的增加而增加; 香丹加入对CPC转化没有明显影响, 但导致水化产物晶体形貌从颗粒状松散搭接转化为片状交织, 且浓度越高片状晶体越多. 在药物释放的最初4h, 载入香丹浓度范围为0.1～0.5mL/g的CPC其释药量符合临床需要. 因此, 载入香丹浓度范围为0.1～0.2mL/g的CPC凝结时间符合临床要求, 比空白CPC具有更高的抗压强度, 在初阶段药物释放量符合治疗需求.

关键词: 磷酸钙骨水泥, 香丹注射液, 性能, 浓度, 药物释放

Abstract:

Effects of the concentrations of Xiangdan injection on properties of calcium phosphate cement（CPC） and the drug release rate were investigated, which would offer the theory evidence for optimizing the concentration of Xiangdan in CPC. Xiangdan and calcium hydrogen phosphate (DCPD) were mixed and dried to prepare Xiangdanloaded DCPD which was subsequently used to prepare CPCs containing various concentrations of Xiangdan. The properties of CPCs with various Xiangdan concentrations were characterized by Gilmore needles, universal material mechanical machine, Xray diffraction (XRD), Fouriertransform infrared spectrometer (FT-IR), and Scanning electron microscope (SEM). The in vitro drug release was studied. The setting time increased with increasing Xiangdan concentration in CPC, while the setting time at a concentration of or below 0.2mL/g could meet the clinic requirement. The compressive strength increased with increasing Xiangdan concentration in CPC. No significant difference in the phase component and conversion degree was observed in the hydrated CPC with and without Xiangdan. SEM tests found that the morphology of crystals changed from particles to plates with the increase of Xiangdan concentration in CPC. In the first 4h, the in vitro release of Xiangdan from CPC with a Xiangdan concentration of 0.1-0.5mL/g could satisfy with the clinic requirement. It can be concluded that both the properties of CPC and the in vitro release of Xiangdan from CPC could meet the clinical applications in the primary stage when Xiangdan concentrations were in the range of 0.1-0.2mL/g.

Key words: calcium phosphate cement, xiangdan injection, property, concentration, drug release

中图分类号:

TB321
R944

李茂红1,2, 屈树新2, 姚宁2,3, 郭悦华2, 张涛2, 翁杰2. 载不同浓度香丹注射液磷酸钙骨水泥性能研究[J]. 无机材料学报, 2010, 25(5): 507-511.

LI Mao-Hong1,2, QU Shu-Xin2, YAO Ning2,3, GUO Yue-Hua2, ZHANG Tao2, WENG Jie2. Properties of Calcium Phosphate Cement with various Concentrations of Xiangdan Injection[J]. Journal of Inorganic Materials, 2010, 25(5): 507-511.

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