载铜锌纳米羟基磷灰石的抗菌性能及机理研究

无机材料学报

载铜锌纳米羟基磷灰石的抗菌性能及机理研究

李吉东^1,2, 李玉宝¹, 王学江¹, 杨维虎¹, 周钢^1,2

1. 四川大学纳米生物材料研究中心, 成都 610064; 2. 四川大学化学学院, 成都 610064

收稿日期:2004-11-22 修回日期:2005-01-11 出版日期:2006-01-20 网络出版日期:2006-01-20

Antibacterial Effect and the Mechanism of Cu²⁺, Zn²⁺ Bearing Nano-hydroxyapatite

LI Ji-Dong^1,2, LI Yu-Bao¹, WANG Xue-Jiang¹, YANG Wei-Hu¹, ZHOU Gang¹

1. The Research Center for Nano-Biomaterial, Sichuan University, Chengdu 610064, China; 2. The College of Chemistry, Sichuan
University, Chengdu 610064, China

Received:2004-11-22 Revised:2005-01-11 Published:2006-01-20 Online:2006-01-20

摘要/Abstract

摘要： 在常压下合成了纳米羟基磷灰石(n-HA)浆料, 并在水介质中制备了载铜、载锌和载铜锌双离子n-HA抗菌材料. 运用原子吸收光谱(AAS)、转靶X射线衍射(XRD)、透射电镜(TEM)等手段对材料的理化性能进行了表征. 并对该抗菌材料的抗菌性能进行了研究. 结果表明, 载铜和载铜锌双离子n-HA抗菌材料对革兰氏阴性菌E.coli和革兰氏阳性菌S.aureus均有较强的抑制和杀灭作用, 而载锌n-HA的抗菌能力较弱. 本文还通过实验探讨了该抗菌材料的抗菌机理.

关键词: 纳米羟基磷灰石, 载铜, 抗菌性能, 抗菌机理

Abstract: Nano-hydroxyapatite (n-HA) slurry was synthesized at normal pressure, and Cu-bearing nano-hydroxyapatite (Cu-HA), Zn-bearing nano-hydroxyapatite (Zn-HA) and (Cu, Zn)-bearing
nano-hydroxyapatite (Cu-Zn-HA) were prepared by the ion exchange method in water medium. The properties of antibacterial materials were characterized by AAS, XRD and
TEM. The results of XRD analysis indicate that Cu²⁺ and Zn²⁺ can occupy Ca²⁺ site and also enter the lattice of hydroxyapatite.
The results of antibacterial experiments show that Cu-HA and Cu-Zn-HA have better antibacterial ability on E. coli and S. aureus, while the
antibacterial effect of Zn-HA is not significant. From the analysis of the antibacterial results, it can be concluded that two mechanisms play
the important role in the antibacterial ability, one is electrostatic attraction which making large amount of bacteria adhere on the n-HA surface, the other is the release of antibacterial metal ions slowly into
medium which can inhibit and kill bacteria.

Key words: nano-hydroxyapatite, Cu-bearing, antibacterial effect, antibacterial mechanism

中图分类号:

TQ455

李吉东,李玉宝,王学江,杨维虎,周钢. 载铜锌纳米羟基磷灰石的抗菌性能及机理研究[J]. 无机材料学报.

LI Ji-Dong,LI Yu-Bao,WANG Xue-Jiang,YANG Wei-Hu,ZHOU Gang. Antibacterial Effect and the Mechanism of Cu²⁺, Zn²⁺ Bearing Nano-hydroxyapatite[J]. Journal of Inorganic Materials.

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