氧化铈团簇酶仿生合成及其对急性肝损伤治疗的研究

doi:10.15541/jim20250086

无机材料学报

• 研究论文 •

氧化铈团簇酶仿生合成及其对急性肝损伤治疗的研究

严弥迦^1,2, 张佳乐^1,2, 张秋红¹, 陈航榕^1,2

1.中国科学院大学杭州高等研究院化学与材料科学学院,杭州 310024;
2.中国科学院上海硅酸盐研究所,上海 200050

收稿日期:2025-02-26 修回日期:2025-03-21
通讯作者: 张秋红, 副研究员. E-mail: zhangqh@ucas.ac.cn
作者简介:严弥迦（1999-）, 女, 硕士研究生. E-mail: yanmijia22@mails.ucas.ac.cn
基金资助:
国科大杭州高等研究院科研基金(B03006C01600407, A05006C019014); 关键陶瓷材料全国重点实验室开放课题（SKL202412SIC）

CeO₂ Clusterzymes: Biomimetic Synthesis and Treatment for Acute Liver Injury

YAN Mijia^1,2, ZHANG Jiale^1,2, ZHANG Qiuhong¹, CHEN Hangrong^1,2

1. School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China;
2. Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

Received:2025-02-26 Revised:2025-03-21
Contact: ZHANG Qiuhong, associate professor. E-mail: zhangqh@ucas.ac.cn
About author:YAN Mijia (1999-), female, Master candidate. E-mail: yanmijia22@mails.ucas.ac.cn
Supported by:
Research Funds of Hangzhou Institute for Advanced Study, UCAS(B03006C01600407, A05006C019014); Opening Project of State Key Laboratory of Advanced Ceramics (SKL202412SIC)

摘要/Abstract

摘要： 对乙酰氨基酚过量服用是临床上急性肝损伤的常见诱因,主要病理特征为大量活性氧累积和炎性细胞浸润。本研究通过仿生矿化工艺制备了一种超小尺寸（约1.3 nm）氧化铈团簇酶（CeO₂ clusterzymes, CeCs）,该材料具有高的氧空位含量（52.6%）和高的Ce³⁺/Ce⁴⁺比（1.06）,对多种活性氧（包括自由基）具有优异的吸附和清除能力,可用于肝细胞保护。动物体内实验进一步证实CeCs可以实现对乙酰氨基酚诱导的急性肝损伤的高效干预治疗,显著延长治疗窗口和逆转无菌炎症,表现出潜在的临床应用价值。

关键词: 氧化铈, 团簇酶, 急性肝损伤, 抗氧化, 抗炎

Abstract: Acetaminophen overdose is a common cause of acute liver injury in clinical settings, characterized by the accumulation of reactive oxygen species (ROS) and infiltration of inflammatory cells. In this study, CeO₂clusterzymes (named as CeCs) of ultra-small size (around 1.3 nm) have been synthesized by a biomimetic mineralization process. The obtained CeCs present a high oxygen vacancy content (52.6%) and a high Ce³⁺/Ce⁴⁺ ratio (1.06), showing excellent adsorption and removal ability to a variety of reactive oxygen species (ROS, including free radicals), which can be used for hepatocyte protection. The in vivo animal experiments further confirmed that CeCs provided highly effective therapeutic intervention for acetaminophen-induced acute liver injury, extending the therapeutic window, and reversing sterile inflammation, underscoring their potential for clinical application.

Key words: cerium oxide, clusterzyme, acute liver injury, antioxidant, anti-inflammatory

中图分类号:

R318

严弥迦, 张佳乐, 张秋红, 陈航榕. 氧化铈团簇酶仿生合成及其对急性肝损伤治疗的研究[J]. 无机材料学报, DOI: 10.15541/jim20250086.

YAN Mijia, ZHANG Jiale, ZHANG Qiuhong, CHEN Hangrong. CeO₂ Clusterzymes: Biomimetic Synthesis and Treatment for Acute Liver Injury[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250086.

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氧化铈团簇酶仿生合成及其对急性肝损伤治疗的研究

CeO₂ Clusterzymes: Biomimetic Synthesis and Treatment for Acute Liver Injury

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氧化铈团簇酶仿生合成及其对急性肝损伤治疗的研究

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CeO₂ Clusterzymes: Biomimetic Synthesis and Treatment for Acute Liver Injury