无机材料学报 ›› 2023, Vol. 38 ›› Issue (5): 489-502.DOI: 10.15541/jim20220716 CSTR: 32189.14.10.15541/jim20220716

所属专题: 【生物材料】肿瘤治疗(202409)

• 综述 • 上一篇    下一篇

铜基纳米酶的特性及其生物医学应用

牛嘉雪1(), 孙思2, 柳鹏飞1, 张晓东1,2, 穆晓宇1()   

  1. 1.天津大学 医学工程与转化医学研究院, 天津 300072
    2.天津大学 理学院, 天津 300350
  • 收稿日期:2022-11-26 修回日期:2023-01-04 出版日期:2023-01-17 网络出版日期:2023-01-17
  • 通讯作者: 穆晓宇, 副研究员. E-mail: muxiaoyu@tju.edu.cn
  • 作者简介:牛嘉雪(1999-), 女, 硕士研究生. E-mail: jiaxueniu@tju.edu.cn
  • 基金资助:
    国家重点研发计划(2021YFF1200700);国家自然科学基金(91859101);国家自然科学基金(81971744);国家自然科学基金(U1932107);国家自然科学基金(82001952);国家自然科学基金(11804248);天津市杰出青年基金(2021FJ-0009);天津市自然科学基金(19JCZDJC34000);天津市自然科学基金(20JCYBJC00940);天津市自然科学基金(21JCYBJC00550);天津市自然科学基金(21JCZDJC00620);天津市自然科学基金(21JCYBJC00490);中国科学院创新交叉团队(JCTD-2020-08);天津大学创新基金

Copper-based Nanozymes: Properties and Applications in Biomedicine

NIU Jiaxue1(), SUN Si2, LIU Pengfei1, ZHANG Xiaodong1,2, MU Xiaoyu1()   

  1. 1. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
    2. School of Sciences, Tianjin University, Tianjin 300350, China
  • Received:2022-11-26 Revised:2023-01-04 Published:2023-01-17 Online:2023-01-17
  • Contact: MU Xiaoyu, associate professor. E-mail: muxiaoyu@tju.edu.cn
  • About author:NIU Jiaxue (1999-), female, Master candidate. E-mail: jiaxueniu@tju.edu.cn
  • Supported by:
    National Key Research and Development Program of China(2021YFF1200700);National Natural Science Foundation of China(91859101);National Natural Science Foundation of China(81971744);National Natural Science Foundation of China(U1932107);National Natural Science Foundation of China(82001952);National Natural Science Foundation of China(11804248);Outstanding Youth Funds of Tianjin(2021FJ-0009);Natural Science Foundation of Tianjin(19JCZDJC34000);Natural Science Foundation of Tianjin(20JCYBJC00940);Natural Science Foundation of Tianjin(21JCYBJC00550);Natural Science Foundation of Tianjin(21JCZDJC00620);Natural Science Foundation of Tianjin(21JCYBJC00490);CAS Interdisciplinary Innovation Team(JCTD-2020-08);The Innovation Foundation of Tianjin University

摘要:

天然酶对维持生物体生命活动的正常运行具有重要意义, 但天然酶固有的缺点诸如不稳定、反应条件苛刻和提纯成本高等限制了其广泛应用。与天然酶相比, 具有高稳定性、低成本、便于结构调控与改性等优点的纳米酶吸引了科学家们的关注。纳米酶的类天然酶活性和选择性使其在生物医学、环境治理、工业生产等领域得到广泛应用。铜作为人体内必需元素和天然酶活性中心金属之一, 铜基纳米酶受到了人们广泛的关注和研究。本综述重点介绍了铜基纳米酶的分类, 包括铜纳米酶、氧化铜纳米酶、碲化铜纳米酶、铜单原子纳米酶和铜基金属有机框架材料纳米酶等, 并阐述了铜基纳米酶的酶学特性和催化机理, 总结了铜基纳米酶在生物传感、伤口愈合、急性肾损伤和肿瘤治疗等方面的应用, 最后对铜基纳米酶面临的挑战和未来的发展方向进行了总结和展望。

关键词: Cu, 纳米酶, 类酶活性, 生物医学应用, 综述

Abstract:

Natural enzymes play an important role in maintaining normal life activities, but suffer in their inherent instability, harsh reaction conditions and high purification costs, which limit their wide applications in vitro. Compared to natural enzymes, nanozymes with high stability, low cost, and ease of structural regulation and modification attract the great interests and are widely applied to biomedicine, environmental control, industrial production and other fields due to their enzyme-like activities and selectivity. As an essential element and one of the active central metals of natural enzymes in the human body, copper-based (Cu-based) nanozymes have received extensive attentions and researches. This review focused on the classification of Cu-based nanozymes, such as Cu nanozymes, Cu oxide nanozymes, Cu telluride nanozymes, Cu single-atom nanozymes, and Cu-based metal organic framework nanozymes. Then this review described the enzyme-like activities and catalytic mechanisms of Cu-based nanozymes, and also summarized the applications of Cu-based nanozymes, including biosensing, wound healing, acute kidney injury, and tumors. The challenges and future development direction of Cu-based nanozymes were proposed.

Key words: Cu, nanozyme, enzyme-like activity, biomedical application, review

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