钛酸钡/硅酸钙复合生物活性压电陶瓷的制备及性能研究

doi:10.15541/jim20210549

无机材料学报 ›› 2022, Vol. 37 ›› Issue (6): 617-622.DOI: 10.15541/jim20210549

所属专题：【生物材料】骨骼与齿类组织修复

钛酸钡/硅酸钙复合生物活性压电陶瓷的制备及性能研究

魏子钦¹^,²(), 夏翔², 李勤², 李国荣², 常江¹^,²()

1.上海师范大学化学与材料科学学院, 上海 200234
2.中国科学院上海硅酸盐研究所, 高性能陶瓷与超微结构国家重点实验室, 上海 200050

收稿日期:2021-08-28 修回日期:2021-10-12 出版日期:2022-06-20 网络出版日期:2021-11-12
通讯作者: 常江, 研究员. E-mail: jchang@mail.sic.ac.cn
作者简介:魏子钦(1996-), 男, 硕士研究生. E-mail: 1149057072@qq.com
基金资助:
国家重点研发计划(2016YFC1100201)

Preparation and Properties of Barium Titanate/Calcium Silicate Composite Bioactive Piezoelectric Ceramics

WEI Ziqin¹^,²(), XIA Xiang², LI Qin², LI Guorong², CHANG Jiang¹^,²()

1. College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China
2. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

Received:2021-08-28 Revised:2021-10-12 Published:2022-06-20 Online:2021-11-12
Contact: CHANG Jiang, professor. E-mail: jchang@mail.sic.ac.cn
About author:WEI Ziqin (1996–), male, Master candidate. E-mail: 1149057072@qq.com
Supported by:
National Key Research and Development Plan of China(2016YFC1100201)

摘要/Abstract

摘要：

压电材料产生的电信号能够促进成骨细胞增殖分化, 但不具有良好的诱导矿化能力; 生物活性材料在生理环境下能够诱导类骨羟基磷灰石的沉积, 但又不能产生电信号促进成骨。因此, 开发出一种既能产生电信号, 又能诱导矿化沉积的复合生物活性压电材料, 具有重要意义。本研究以钛酸钡为压电组分, 以硅酸钙为生物活性组分, 采用固相烧结法制备了钛酸钡/硅酸钙复合生物活性压电陶瓷, 测试了压电性能, 并用体外矿化实验评价了诱导矿化能力。硅酸钙复合含量达到30%时, 复合陶瓷仍具有一定的压电性能(d₃₃=4 pC·N^-1), 并且能够在模拟体液中诱导磷酸钙沉积。钛酸钡与硅酸钙的复合能够同时具有压电性和生物活性, 为骨修复材料提供了新的选择。

关键词: 钛酸钡, 硅酸钙, 压电性, 生物活性

Abstract:

Electrical signals generated by piezoelectric materials can promote proliferation and differentiation of osteoblasts, but they can’t induce mineralization, while bioactive materials can induce the deposition of bone like hydroxyapatite in physiological environment, but can not generate electrical signal to promote osteogenesis. Therefore, it is of great significance to develop a composite bioactive piezoelectric material that can not only generate electrical signals, but also induce mineralization and deposition. Here, we used barium titanate as piezoelectric component and calcium silicate as bioactive component to prepare barium titanate/calcium silicate composite as bioactive/piezoelectric ceramics by solid-state sintering method. Piezoelectric properties of the ceramics were tested, and the ability of inducing mineralization was evaluated by in vitro mineralization experiment. The experimental results show that when the content of calcium silicate reaches 30%, the composite ceramics still have certain piezoelectric property (d₃₃=4 pC·N^-1), and can induce the deposition of calcium phosphate in simulated body fluid. Therefore, the combination of barium titanate and calcium silicate can synchronously afford piezoelectric and biological activities, which provides a new choice for bone repair materials.

Key words: barium titanate, calcium silicate, piezoelectricity, bioactivity

中图分类号:

TQ174

魏子钦, 夏翔, 李勤, 李国荣, 常江. 钛酸钡/硅酸钙复合生物活性压电陶瓷的制备及性能研究[J]. 无机材料学报, 2022, 37(6): 617-622.

WEI Ziqin, XIA Xiang, LI Qin, LI Guorong, CHANG Jiang. Preparation and Properties of Barium Titanate/Calcium Silicate Composite Bioactive Piezoelectric Ceramics[J]. Journal of Inorganic Materials, 2022, 37(6): 617-622.

图/表 8

图1 工艺流程示意图

Fig. 1 Flow chart of sample preparation

表1 复合陶瓷的原料组成

Table 1 Raw material composition of the composite ceramics

	BT	0.9BT 0.1CS	0.8BT 0.2CS	0.7BT 0.3CS	0.6BT 0.4CS	CS
BT/g	2.0000	1.8951	1.7782	1.6481	1.5014	0
CS/g	0	0.1049	0.2215	0.3519	0.4986	2.0000

图2 复合陶瓷的XRD图谱(a)及其SEM照片(b)

Fig. 2 XRD patterns (a) and SEM images (b) of composite ceramics

表2 复合陶瓷的压电常数d33

Table 2 Piezoelectric constant d33 of composite ceramics

	BT	0.9BT0.1CS	0.8BT0.2CS	0.7BT0.3CS	0.6BT0.4CS	CS
Before mineralization/(pC·N^-1)	169	44	11	4	1	0
After mineralization/(pC·N^-1)	161	39	8	3	0	0

图3 复合陶瓷的压电性能表征

Fig. 3 Characterization of piezoelectric properties of composite ceramics BT; (b) 0.9BT0.1CS; (c) 0.8BT0.2CS; (d) 0.7BT0.3CS; (e) 0.6BT0.4CS; (f) CS; (g) Variation trend of hysteresis loop; (h) Piezoelectric constant Colorful figures are available on website

图4 体外矿化表征

Fig. 4 Characterization of in vitro mineralization (a-h) SEM images of different ceramics soaked in SBF for 0 and 14 d; (i-h) EDS spectra of different ceramics soaked in SBF for 14 d SBF: Simulated body fluid

表3 样品矿化14 d后的表面元素组成

Table 3 Surface element composition of sample after 14 d mineralization

	BT/%	0.9BT0.1CS/%	0.8BT0.2CS/%	0.7BT0.3CS/%
O	59.98	60.53	61.37	7.84
P	-	0.74	0.65	6.81
Si	-	2.57	7.34	0.23
Ca	-	2.04	4.12	8.62
Ti	19.97	17.38	14.42	2.65
Ba	20.05	16.74	12.10	2.71
Ca/P	-	2.76	6.34	1.27

图5 不同稀释度的BT和0.7BT0.3CS浸提液对HDF细胞活力影响

Fig. 5 Cell activity of series solutions of extracts from BT and 0.7BT0.3CS by CCK8 assay *** indicates p<0.01

参考文献 26

[1]	ANTALYA H, JOHANNA B, RUSTOM L E, et al. Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives. Biomaterials, 2018, 180: 143-162. DOI URL
[2]	LOBB D C, DEGEORGE B R, CHHABRA A B. Bone graft substitutes: current concepts and future expectations. The Journal of Hand Surgery, 2019, 44(6): 497-505. DOI URL
[3]	MAAZOUZ Y, CHIZZOLA G, DOBELIN N, et al. Cell-free, quantitative mineralization measurements as a proxy to identify osteoinductive bone graft substitutes. Biomaterials, 2021, 275: 120912. DOI URL
[4]	HENCH L L, POLAK J M. Third-generation biomedical materials. Science, 2002, 295(5557): 1014-1017. DOI URL
[5]	FUKADA E, YASUDA I. On the piezoelectric effect of bone. Journal of the Physical Society of Japan, 1957, 12(10): 1158-1162. DOI URL
[6]	BASSETT C A L, BECKER R O. Generation of electric potentials by bone in response to mechanical stress. Science, 1962, 137(3535): 1063-1064. PMID
[7]	FUKADA E, YASUDA I. Piezoelectric effects in collagen. Japanese Journal of Applied Physics, 1964, 3(8): 117-121. DOI URL
[8]	PARK J B, RECUM A F V, KENNER G H, et al. Piezoelectric ceramic implants-a feasibility study. Journal of Biomedical Materials Research, 1980, 14(3): 269-277. DOI URL
[9]	ATTILIO M, JONATHAN B, GIUSEPPE D V, et al. Two-photon lithography of 3D nanocomposite piezoelectric scaffolds for cell stimulation. ACS Applied Materials & Interfaces, 2015, 7(46): 25574-25579.
[10]	BUSUIOC C, OLARET E, STANCU I C, et al. Electrospun fibre webs templated synthesis of mineral scaffolds based on calcium phosphates and barium titanate. Nanomaterials, 2020, 10: 772. DOI URL
[11]	KHARE D, BASU B, DUBEY A K. Electrical stimulation and piezoelectric biomaterials for bone tissue engineering applications. Biomaterials, 2020, 258: 120280-1-25.
[12]	WEINER S, ADDADI L. Crystallization pathways in biomineralization. Annual Review of Materials Research, 2011, 41: 21-40. DOI URL
[13]	REZNIKOV N, STEELE J A M, FRATZL P, et al. A materials science vision of extracellular matrix mineralization. Nature Reviews Materials, 2016, 1(8): 16041. DOI URL
[14]	WU C T, CHANG J. Silicate bioceramics for bone tissue regeneration. Journal of Inorganic Materials, 2013, 28(1): 29-39. DOI URL
[15]	LIN K L, CHANG J, WANG Z. Fabrication and the characterisation of the bioactivity and degradability of macroporous calcium silicate bioceramics in vitro. Journal of Inorganic Materials, 2005, 20(3): 692-698.
[16]	LIU X Y, DING C X, WANG Z Y. Apatite formed on the surface of plasma-sprayed wollastonite coating immersed in simulated body fluid. Biomaterials, 2001, 22(14): 2007-2012. DOI URL
[17]	WANG X, ZHOU Y, XIA L, et al. Fabrication of nano-structured calcium silicate coatings with enhanced stability, bioactivity and osteogenic and angiogenic activity. Colloids Surf. Biointerfaces, 2015, 126: 358-366. DOI URL
[18]	WANG S G, XU Y C, ZHOU J, et al. In vitro degradation and surface bioactivity of iron-matrix composites containing silicate- based bioceramic. Bioactive Materials, 2017, 2(1): 10-18. DOI URL
[19]	KOKUBO T, TAKADAMA H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials, 2006, 27(15): 2907-2915. DOI URL
[20]	LI H T, ZHANG B P, WEN J B, et al. Influences of sintering temperature on structure and properties of Cu-doped lead-free LNKN ceramics. Journal of Functional Materials, 2011, 42(S5): 931-934.
[21]	ZHANG S, YU F, GREEN D J. Piezoelectric materials for high temperature sensors. Journal of the American Ceramic Society, 2011, 94(10): 3153-3170. DOI URL
[22]	TANG Y, WU C, WU Z, et al. Fabrication and in vitro biological properties of piezoelectric bioceramics for bone regeneration. Scientific Reports, 2017, 7: 43360. DOI URL
[23]	KIM D, HAN S A, KIM J H, et al. Biomolecular piezoelectric materials: from amino acids to living tissues. Advanced Materials, 2020, 32(14): 1906989.
[24]	BAXTER F R, TURNER I G, BOWEN C R, et al. The structure and properties of electroceramics for bone graft substitution. Key Engineering Materials, 2008, 361(22): 99-102.
[25]	MAEDA H, TSUDA K, FUKADA E. Dependence on temperature and hydration of piezoelectric, dielectric and elastic-constants of bone. Japanese Journal of Applied Physics, 1976, 15(12): 2333-2336. DOI URL
[26]	SALAHINEJAD E, BAGHJEGHAZ M J. Structure, biomineralization and biodegradation of Ca-Mg oxyfluorosilicates synthesized by inorganic salt coprecipitation. Ceramics International, 2017, 43(13): 10299-10306. DOI URL

钛酸钡/硅酸钙复合生物活性压电陶瓷的制备及性能研究

Preparation and Properties of Barium Titanate/Calcium Silicate Composite Bioactive Piezoelectric Ceramics

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