Journal of Inorganic Materials ›› 2015, Vol. 30 ›› Issue (1): 53-58.doi: 10.15541/jim20140178

• Orginal Article • Previous Articles     Next Articles

Synthesis and Application of Magnetic Iron Oxide Nanoparticles as High Efficiency Magnetic Resonance Imaging Contrast Agent

Jun WANG1(), Bao-Lin ZHANG1(), Gao YANG1, Lei WANG2, Song-Bo XIE1, Xuan LI1, Fa-Bao GAO2()   

  1. 1. State Key Laboratory Breeding Base of Nonferrous Metals and Specific Materials Processing, School of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, China
    2. Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2014-04-08 Revised:2014-06-20 Online:2015-01-20 Published:2014-12-29
  • About author:WANG Jun. E-mail: wjs19892008@126.com
  • Supported by:
    National Natural Science Foundation of China (51162003)

Abstract:

Iron oxide nanoparticles were synthesized by thermal decomposition of iron (III) acetylacetonate (Fe(acac)3) in poly(ethylene glycol) (PEG), which was used as the solvent, reducing agent and modifying agent. X-ray powder diffraction (XRD) analysis indicates that the nanoparticles have magnetite crystal structure. The results of transmission electron microscope (TEM) show that the shapes of iron oxide nanoparticles coated with PEG are equiaxial with uniform morphology. Particles and Zeta potential analyses show that the surface of iron oxide nanoparticles is negatively charged, and their hydrodynamics size dispersed in deionized water is 20 nm. Iron oxide nanoparticles show superparamagnetic behavior at room temperature and high r2/r1 ratio. MTT studies show that PEG-SPIONs have low cytotoxicity. In vivo magnetic resonance imaging reveals their excellent contrast effects of the PEG-SPIONs. This work demonstrates that iron oxide nanoparticles coated with PEG can be excellent T2 MRI contrast agents.

Key words: iron oxide, nanoparticles, superparamagnetic, magnetic resonance imaging (MRI), contrast agents

CLC Number: 

  • O614