Influence of Bimodal Mesopores Large Pore Structure on Ibuprofen Loading and Delivery Property

doi:10.3724/SP.J.1077.2012.00337

Abstract

Abstract:

Three kinds of bimodal mesopores silica-based nanomaterials (BMMs) with different accumulated pores structure were synthesized by tuning the stirring rate in the preparation process and then functionalized with silane coupling agent 3-(2-aminoethylamino) propyltrimethoxysilane (NN-TES). The modified BMMs were used as ibuprofen carriers and their delivery property were studied with Korsmeyer-Peppas model. With the help of XRD, TEM, N₂ adsorption and desorption isotherms and elemental analysis, it indicated that the hydrolysis and condensation polymerization rate of TEOS would be influenced by changing the stirring rate, which resulted in the formation of three kinds of BMMs with different small pores order and large accumulated pores structure. When applying NN-TES modified BMMs as ibuprofen carriers, the ibuprofen loading amount in three different kinds of BMMs were almost the same, while the release rate had great difference from each other. These results demonstrate that the drug loading capacity was affected by the small pores of BMMs, while the large pores of BMMs would influence the drug diffusion behaviors in the mesoporous channels, leading to the increase of release rate with the increment of the large pore size.

Key words: bimodal mesopores, SiO₂, ibuprofen, loading, delivery

CLC Number:

GAO Lin, SUN Ji-Hong, LI Yu-Zhen, REN Bo. Influence of Bimodal Mesopores Large Pore Structure on Ibuprofen Loading and Delivery Property[J]. Journal of Inorganic Materials, 2012, 27(4): 337-342.

Figures/Tables 5

Fig. 1 XRD patterns of three kinds of BMMs

Fig. 2 TEM images of three kinds of BMMs and typical particle size distribution (insert)

Fig. 3 N2 adsorption-desorption isotherms of three series of BMMs and their corresponding plots of the pore size distribution (insert)

Fig. 4 Loadings of Ibuprofen in three kinds of modified BMMs

Fig. 5 Ibuprofen release profiles (A) and the initial 60wt% of ibuprofen release fitted with the Korsmeyer-Peppas model (B)

References 29

[1]	Vallet-Regi M, Ramila A, Del Real R P, et al. A new property of MCM-41: drug delivery system. Chem. Mater. , 2001, 13(2): 308-311.
[2]	Cavallaro G, Pierro P, Palumbo F S, et al. Drug delivery devices based on mesoporous silicate. Drug Deliv., 2004, 11(1): 41-46.
[3]	Izquierdo-Barba I, Martinez A, Doadrio A L, et al. Release evaluation of drugs from ordered three-dimensional silica structures. Eur. J. Pharm. Sci., 2006, 26(5): 365-373.
[4]	Ford D M, Simanek E E, Shantz D F. Engineering nanospaces: ordered mesoporous silicas as model substrates for building complex hybrid materials. Nanotechnology, 2005, 16(7): S458-S475.
[5]	Zhang H D, Sun Y H, Ye K Q, et al. Oxygen sensing materials based on mesoporous silica MCM-41 and Pt(II)–porphyrin complexes. J. Mater. Chem., 2005, 15(31): 3181-3186.
[6]	Brieler F J, Grundmann P, Fröba M, et al. Comparison of the magnetic and optical properties of wide-gap (II, Mn)VI nanostructures confined in mesoporous silica. Eur. J. Inorg. Chem., 2005, 36(47): 3597-3611.
[7]	Jia M J, Seifert A, Berger M, et al. Hybrid mesoporous materials with a uniform ligand distribution: synthesis, characterization, and application in epoxidation catalysis. Chem. Mater., 2004, 16(5): 877-882.
[8]	Slowing I I, Trewyn B G, Giri S, et al. Mesoporous silica nanoparticles for drug delivery and biosensing applications. Adv. Funct. Mater., 2007, 17(8): 1225-1236.
[9]	Balas F, Manzano M, Horcajada P, et al. Confinement and controlled release of bisphosphonates on ordered mesoporous silica- based materials. J. Am. Chem. Soc., 2006, 128(25): 8116-8117.
[10]	Huang X L, Li L L, Liu T L, et al. The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. ACS Nano, 2011, 5(7): 5390-5399.
[11]	Doadrio A L, Sousa E M B, Doadrio J C, et al. Mesoporous SBA-15 HPLC evaluation for controlled gentamicin drug delivery. J. Control Release, 2004, 97(1): 125-132.
[12]	Qu F Y, Zhu G S, Huang S Y, et al. An effective control release of captopril drug by silylation of mesoporous MCM-41. Chemphyschem., 2006, 7(2): 400-406.
[13]	Munoz B, Ramila A, Perez-Pariente J, et al. MCM-41 Organic modification as drug delivery rate regulator. Chem. Mater., 2003, 15(2): 500-503.
[14]	Qu F Y, Zhu G S, Lin H M, et al. A controlled release of ibuprofen by systematically tailoring the morphology of mesoporous silica materials. Journal of Solid State Chemistry, 2006, 179(7): 2027-2035.
[15]	Sun J H, Shan Z P, Maschmeyer T, et al. Synthesis of bimodal nanostructured silicas with independently controlled small and large mesopore sizes. Langmuir, 2003, 19(20): 8395-8402.
[16]	Gao L, Sun J H, Li Y Z, et al. Bimodal mesoporous silicas functionalized with different level and species of the amino groups for adsorption and controlled release of aspirin. Journal of Nanoscience and Nanotechnology, 2011, 11(8): 6690-6697.
[17]	Manzano M, Aina V, Arean C F, et al. Studies on MCM-41 mesoporous silica for drug delivery: effect of particle morphology and amine functionalization. Chemical Engineering Journal, 2008, 137(1): 30-37.
[18]	Trewyn B G, Whitman C M, Lin V S Y. Morphological control of room-temperature ionic liquid templated mesoporous silica nanoparticles for controlled release of antibacterial agents. Nano Lett., 2004, 4(11): 2139-2143.
[19]	Zhu Y F, Shi J L, Shen W H, et al. Novel stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/polyelectrolyte multilayers core-shell structure. Angew. Chem. Int. Ed., 2005, 44(32): 5083-5087.
[20]	Zhu Y F, Shi J L, Li Y S, et al. Hollow mesoporous spheres with cubic pore network as a potential carrier for drug storage and its in vitro release kinetics. J. Mater. Res., 2005. 20(1): 54-61.
[21]	Xu W J, Gao Q, Xu Y, et al. Controllable release of ibuprofen from size-adjustable and surface hydrophobic mesoporous silica spheres. Powder Technology, 2009, 191(1/2): 13-20.
[22]	Kokubo T, Kushitani H, Sakka S, et al. Solution able to reproduce in vivo surface-structure changes in bioactive glass-ceramics A-W3. J. Biomed. Mater. Res. , 1990, 24(6): 721-734.
[23]	Chen C Y, Li H X, Davis M E. Studies on mesoporous materials. (I) Synyhesis and characterization of MCM-41. Microporous Mater. , 1993, 2(1): 17-26.
[24]	Huo Q S, Leon R, Petroff P M, et al. Mesostructre design with gemini surfactants: supercage formation in a three dimensional hexagonal array. Science, 1995, 268(5212): 1324-1327.
[25]	Ying J Y, Benziger J B, Navrotsky A.The structural evolution of alkoxide silica gels to glass: efect of catalyst pH. J. Am. Ceram. Soc., 1993, 76(10): 2571-2582.
[26]	顾宇辉, 古宏晨, 徐宏, 等(GU Yu-Hui, et al).正硅酸乙酯水解过程的半经验量子化学研究. 无机化学学报(Chinese J. Inorg. Chem), 2003, 19(12): 1301-1306.
[27]	Gregg S J,Sing K S W. Adsorption, Surface Area and Porosity. Academic Press: London. 1982.
[28]	Costa P J, Lobo M S. Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci. , 2001, 13(2): 123-133.
[29]	Heikkila T, Salonen J, Tuura J, et al. Mesoporous silica material TUD-I as a drug delivery system. Int. J. Pharm. , 2007, 331(1): 133-138.