Preparing Biomedical CaCO3/HA Composite with Oyster Shell

doi:10.15541/jim20190144

Abstract

Abstract:

To reduce the cost of HA and improve degradation performance of HA, oyster shells were used as raw materials to prepare CaCO₃/ hydroxyapatite (HA) composite materials by a hydrothermal method. Phase analysis and SEM/TEM observation revealed that as-prepared CaCO₃/HA composites had a morphology of HA nanoparticles growing on the lamellar CaCO₃. Three kinds of CaCO₃/HA composites (20%HA、40%HA、60%HA) with HA content of 20%, 40% and 60% were prepared by controlling the proportion of calcium and phosphorus. The actual content of HA in three obtained different composites, determined by ICP, were 17.52%, 34.30% and 43.24%, respectively. With the increase of HA content, the specific surface area and thermal stability of CaCO₃/HA composite are improved. Samples were immersed in PBS simulated body fluid for 14 d to evaluate their in vitro degradation ability. The results showed that degradation rates of three kinds of composites with different HA contents (20%HA, 40%HA and 60%HA) were 15.2%, 12.0% and 10.8%, respectively. The degradation rate decreased with the increase of HA proportion in the composite. All data indicates that the hydrothermal synthesis of CaCO₃/HA composite can control the conversion degree of HA and then adjust the degradation rate of CaCO₃/HA composite by designing the ratio of calcium and phosphorus elements, which have potential application in orthopedics.

Key words: oyster shell, hydroxyapatite, calcium carbonate, degradation rate, orthopedic application

CLC Number:

TQ342

LIU Ziyang, GENG Zhen, LI Zhaoyang. Preparing Biomedical CaCO₃/HA Composite with Oyster Shell[J]. Journal of Inorganic Materials, 2020, 35(5): 601-607.

Figures/Tables 10

References 21

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Element	Calcined product /(mg·kg^-1)	Limit/(mg·kg^-1)
Pb	<10	30
Cd	<1.5	5
Hg	<1	5
As	<1	3

Element	Calcined product /(mg·kg^-1)	Limit/(mg·kg^-1)
Pb	<10	30
Cd	<1.5	5
Hg	<1	5
As	<1	3

	20%HA	40%HA	60%HA
Concentration of Ca/(mg·L^-1)	(19.91±0.72)	(20.00±1.08)	(20.02±0.52)
Concentration of P/(mg·L^-1)	(1.62±0.17)	(3.19±0.22)	(4.02±0.19)
Degree of HA transition/%	(17.5±0.57)	(34.3±1.02)	(43.2±0.33)

	20%HA	40%HA	60%HA
Concentration of Ca/(mg·L^-1)	(19.91±0.72)	(20.00±1.08)	(20.02±0.52)
Concentration of P/(mg·L^-1)	(1.62±0.17)	(3.19±0.22)	(4.02±0.19)
Degree of HA transition/%	(17.5±0.57)	(34.3±1.02)	(43.2±0.33)

	20%HA		40%HA		60%HA		CaCO₃
Degradation time/d	Concentration of Ca²⁺/(mg·L^-1)	Degradation rate/%	Concentration of Ca²⁺/(mg·L^-1)	Degradation rate/%	Concentration of Ca²⁺/(mg·L^-1)	Degradation rate/%	Concentration of Ca²⁺/(mg·L^-1)	Degradation rate/%
7	(16.13±0.40)	8.1	(13.39±0.23)	6.7	(11.61±0.92)	5.8	(18.93±0.17)	9.8
14	(30.26±1.12)	15.2	(24.02±0.83)	12.0	(21.62±1.36)	10.8	(42.70±0.19)	22.1
21	(43.20±1.47)	21.7	(33.40±1.38)	16.2	(28.11±1.07)	14.3	(56.41±0.32)	29.2

Preparing Biomedical CaCO₃/HA Composite with Oyster Shell

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