Abstract: A noval Sr-containing calcium phosphate cement (Sr-CPC) was synthesized by mixing tetracalcium phosphate, dicalcium phosphate anhydrous, strontium hydrogen phosphate and phosphate acid. The
effects of weight ratio of cement powder to liquid (P/L), the content of Sr and immersion time of samples in simulated body fluid (SBF) on their compressive strength and microstructure of samples were investigated.
The results show that there exists an optimum P/L ratio for each cement paste with an excellent workability and setting times, and the setting times of the cement paste obtained at its optimum P/L ratio meet
the clinical demands. After immersion in SBF for 24h, the Sr-CPC has transformed into Sr-containing deficient-calcium apatites. The content of Sr and immersion time of samples in SBF have distinct
effects on the compressive strength (CS) of the cement hardened bodies. A proper content of Sr and a shorter immersion time are beneficial to improving the CS, and the variation of macrostructure plays
a significant role in the CS of the hardened bodies during immersion in SBF.

Key words: Calcium phosphate cement, strontium, hydroxyapatite, compressive strength