Hydraulic Characteristic and Osteoinduction Capacity of Calcium Phosphate/BMP Bioactive Bone Cement

Abstract

Abstract: Calcium phosphate(CPC)/BMP bioactive composite bone cement was prepared with ultrafine α-tricalcium phosphate (α-TCP) powders and assist agent premixed with freezed bone morphogenetic protein
(BMP) powders. By means of the hydraulic characterization, the composition, cement liquid and promoting solidification agent of the bone cement were optimized. Osteogenesis of the BMP combined bone cement
was investigated in the rat muscle pouch. Results show that the novel bone cement with excellent hydraulic properties can be developed with 0.95α-TCP, 0.025CaHPO₄, 0.025CaO as the basic composition
and 0.25mol/L NaH₂PO₄/Na₂HPO₄ solution([P]_T=0.5mol/L)as the cement solution, which can satisfy with the harden strength required for clinic surgery. Initial setting time and final
setting time of the bone cement are 6min and 30min respectively. The particle size of α-TCP has great influence on the characteristics of bone cement, and the suitable particle size (d₅₀)
will be 1.3μm. The compressive strength of the bone cements reaches 33 MPa after soaking in Hank’s solution for 5 days. The morphology of the bone cement becomes a network of hydroxyapatite
(HA) after soaking. Ectopic osteogenesis of CPC/BMP composite bone cement is distinct, and lamellar bone can form within 4 weeks, proving the strong osteo-induction capacity of the materials. This bioactive
bone cement with good hydraulic characteristics and strong osteogenesis is expected to be a promising bone grafting materials for tissue engineering.

Key words: calcium phosphate, bone cement, hydraulic characteristics, bone morphogenetic protein （BMP）

CLC Number:

R318
R329

YANG Wei-Zhong,ZHOU Da-Li,YIN Guang-Fu,YIN Shao-Ya,ZHENG Chang-Qiong. Hydraulic Characteristic and Osteoinduction Capacity of Calcium Phosphate/BMP Bioactive Bone Cement[J]. Journal of Inorganic Materials.

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