Core-shell Structured Hydroxyapatite/Mesoporous Silica Nanoparticle: Preparation and Application in Drug Delivery

doi:10.15541/jim20170361

Abstract

Abstract:

Core-shell nanoparticle is a kind of composite nanomaterials with unique structure and properties, which has important application prospects in the fields of catalysis, biomedicine and photonic crystal, etc. A new kind of materials, core-shell structured HAp@mSiO₂ nanoparticles with mesoporous were prepared by improved Stöber coating method using hydroxyapatite (HAp) nanoparticles as core and cetyltrimethylammonium bromide (CTAB) as mesoporous template. By controlling concentration of tetraethyl orthosilicate (TEOS) and its hydrolysis and condensation kinetics, the thickness of mSiO₂shell coating on the core HAp surface could be well regulated. The results of TEM, EDS, XRD, FT-IR, and BET testing show that the prepared HAp@mSiO₂ nanoparticles have the characteristics of high specific surface area, narrow pore size and uniform distribution. And using the Ibuprofen as model drug, the prepared materials were tested for drug adsorption and release experiments. It is found that the obtained core-shell structured materials also have good drug control properties and pH response characteristics, and can effectively control the drug release rate and release amount through altering the mSiO₂ shell thickness.

Key words: core-shell structure, hydroxyapatite, mesoporous silica, drug release, pH response

CLC Number:

TQ1741

SONG Jing-Jing, CHEN Bo, LIN Kai-Li. Core-shell Structured Hydroxyapatite/Mesoporous Silica Nanoparticle: Preparation and Application in Drug Delivery[J]. Journal of Inorganic Materials, 2018, 33(6): 623-628.

Figures/Tables 8

Fig. 1 TEM images of the kernel HAp and HAp@mSiO2 coated with different shells(a, b) HAp; (c, d) HAp@mSiO2-1; (e, f) HAp@mSiO2-2; (g, h) HAp@mSiO2-3

Fig. 2 EDS pattern of HAp@mSiO2-2 after mesoporous silica coating

Fig. 3 XRD patterns of core HAp and HAp@mSiO2 with different shell thicknesses(a) HAp; (b) HAp@mSiO2-1; (c) HAp@mSiO2-2; (d) HAp@mSiO2-3

Fig. 4 FT-IR spectra of core HAp and HAp@mSiO2 with different shell thicknesses(a) HAp; (b) HAp@mSiO2-1; (c) HAp@mSiO2-2; (d) HAp@mSiO2-3

Table 1 Pore size, specific surface area, and shell thickness for kernel HAp and different HAp@mSiO2 samples

Samples	V_p/(cm³·g^-1)	S_BET/(m²·g^-1)	D_p/nm	Shell thickness/nm
HAp	1.024	69.7	1.689	—
HAp@mSiO₂-1	0.608	653.4	1.929	9.59
HAp@mSiO₂-2	0.591	666.6	2.188	10.01
HAp@mSiO₂-3	0.467	714.1	2.450	12.97

Fig. 5 N2 adsorption/desorption isotherms for core HAp and HAp@mSiO2 with different shell thicknesses(a) HAp; (b) HAp@mSiO2-1; (c) HAp@mSiO2-2; (d) HAp@mSiO2-3

Fig. 6 Cumulative IBU release from core HAp and HAp@mSiO2 with different shell thicknesses in the release media of PBS (pH=7.4)

Fig. 7 Cumulative IBU release from HAp@mSiO2-2 in the release media of PBS with different pH

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