Synthesis of Polydopamine Modified Mesoporous Silica Microspheres for Encapsulation of L-menthol

doi:10.15541/jim20160486

Abstract

Abstract:

Ordered mesoporous silica materials (OMS) possess high specific surface areas, large pore volume, open channel structure, easily tunable surface functionalities, and good biocompatibility. They have great potential for application in various fields, such as drug delivery, enzyme immobilization, and catalysis. In this study, ordered mesoporous silica microspheres with large pore sizes were synthesized via a non-polar solvent assisted co-assembly method in a water- n-hexane biliquid solution. The obtained mesoporous silica microspheres possess large pore size of 6.9 nm and high surface area of 615 m²/g. Through a nanocasting method, L-menthol was successfully loaded into the mesopores. Through an interface polymerization of dopamine, polydopamine (PDA) was deposited on the external surface of the composite microspheres. By monitoring the weight change of the composite microspheres during treatment by hot air flow, the menthol release behavior was evaluated. As a result of the presence of permeable PDA in shell, the composite microspheres were found to release L-menthol in a controllable way, especially at an appropriate temperature of about 50℃. This study provides an important primary guideline for potential applications of mesoporous silica functionalized with PDA in bio-medicine, adsorption and separation, and so on.

Key words: mesoporous silica, polydopamine, L-menthol, controlled release

CLC Number:

TQ174

BAI Jia-Feng, WANG Xi-Qing, CHEN Yi-Chang, DENG Yong-Hui, LI Zhi-Hua, LIU Hong, LIU Shao-Hua. Synthesis of Polydopamine Modified Mesoporous Silica Microspheres for Encapsulation of L-menthol[J]. Journal of Inorganic Materials, 2017, 32(8): 845-850.

Figures/Tables 8

Fig. 1 The synthetic route to polydopamine functionalized mesoporous silica microspheres for loading L-menthol(a) Synthesis of ordered mesoporous silica microspheres with pseudo core-shell structure via non-polar solvent assisted co-assembly approach; (b) Loading L-menthol through “nanocasting” method; (c) Polymerization of dopamine on the surface of microspheres with embedded L-menthol

Fig. 2 FESEM and TEM (inset) images of the mesoporous silica (mSiO2) before (a) and after (b) coating with PDA

Fig. 3 Nitrogen adsorption-desorption isotherm and pore size distribution curves of mSiO2 (inset)

Fig. 4 FTIR spectra of (a) SiO2-CTAB microsphere and (b) mSiO2 after removing CTAB, (c) mSiO2-menthol microsphere, (d) mSiO2- menthol@PDA microsphere

Fig. 5 Wide-angle XRD patterns of the commercial L-menthol crystal (a) and mSiO2 loaded with L-menthol (b)

Fig. 6 Release curves of L-menthol as a function of time in mSiO2-menthol (a) and mSiO2-menthol@PDA (b) in air flow at 30℃

Fig. 7 Release rate of L-menthol as a function of time in mSiO2- menthol (a) and mSiO2-menthol@PDA (b) in air flow at 50℃

Fig. 8 Release rate of L-menthol as a function of time in mSiO2- menthol (a) and mSiO2-menthol@PDA (b) in air flow at 80℃

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