Setting Mechanism of Nano-hydroxyapatite/Chitosan Bone Cement

doi:10.3724/SP.J.1077.2006.01197

Abstract

Abstract: A n-HA/chitosan composite cement containing ZnO as the coagulant was prepared, and its physic-chemical properties and the setting mechanism were also investigated. The results showed that both the compressive strength and the corresponding setting time of the cement could meet with the demand in clinic. A chelate having the tight network structure was formed due to the reaction of Zn²⁺and Ca²⁺ ions with amino group of chitosan, which produced a contractive force. The force extruded H₂O molecules out of the cement body and made the cement set fast, and with higher compressive strength.

Key words: nano-hydroxyapatite, chitosan, zinc oxide, coagulant, bone cementend

CLC Number:

TB321

ZHANG Li,LI Yu-Bao,ZHOU Gang,LU Guo-Yu,ZUO Yi. Setting Mechanism of Nano-hydroxyapatite/Chitosan Bone Cement[J]. Journal of Inorganic Materials, DOI: 10.3724/SP.J.1077.2006.01197.

References

[1] Li Y B, Wijn J D, Groot K D, et al. J Mater Sci: Mater Med, 1994, 5: 252--255.
[2] Li Y B, Klein C P A T, Groot K D, et al. J Mater Sci: Mater Med, 1994, 5: 263--268.
[3] Yang Z, Yuan H, Zou P, et al. Journal of Materials Science: Materials in Medicine, 1997, 8 (11): 697--701.
[4] Chu C L, Lin P H, Dong Y S, et al. Journal of Materials Science Letters, 2002, 21: 1793--1798.
[5] Zhang Y, Zhang M Q. Journal of Biomedical Materials Research, 2002, 62: 378--386.
[6] Kumar G, Bristow J F, Smith P J, et al. Ploymer, 2000, 41: 2157--2163.
[7] Wang J H, Wei C W, Liu H C, et al. Journal of Biomedical Materials Research, 2003, 64A: 606--615.
[8] Muzzarelli R A A, Biagini G, Debenedittis A, et al. Carbohydrate Polymer, 2001, 45: 35--41.
[9] Sivakumar M, Manjubala I, Panduranga Rao K. Carbohydrate Polymer, 2002, 49: 281--288.
[10] Zhang Li, Li Yubao, Yang Aiping, et al. Journal of Materials Science: Materials in Medicine. 2005, 16 (3): 213--219.
[11] 张利, 李玉宝, 杨爱萍, 等. 功能材料, 2005, 36 (2): 314--317.
[12] 陈歌, 蒋电明. 创伤外科杂志, 2002, 4: 55--58.
[13] Kweon D K, Lim S T. Journal of Applied Polymer Science, 2003, 87 (11): 1784--1789.
[14] 蒋挺大主编. 壳聚糖. 北京: 化学工业出版社, 2001. 51--89.
[15] Brugnerotto J, Lizardi J, Goycoolea F M, et al. Polymer, 2001, 42: 3569--3580.
[16] Garnpimol C. Ritthidej, Thawatchai Phaechamud, Tamotsu Koizumi. International Journal of Pharmaceutics, 2002, 232: 11--22.
[17] Corrado Muzzarelli, Giorgio Tosi, Oriano Francescangeli, et al. Carbohydrate Research, 2003, 338: 2247--2255.
[18] Jia Zhishen, Shen Dongfeng, Xu Weiliang. Carbohydrate Research, 2001, 333: 1--6.
[19] Juang R S, Wu F C, Tsang R L. Water Research, 1999, 33 (10): 2403--2409.
[20] Wang X H, Li D P, Wang W J, et al. Biomaterials, 2003, 24: 3213--3220.
[21] Sawai J. Journal of Microbiological Methods. 2003, 54: 177--182.
[22] Wang X, Du Y, Liu H. Carbohydrate Polymers, 2004, 56: 21--26.