Puerarin/Mesoporous Bioactive Glass Composites: Preparation and In Vitro Synergistic Osteogenic-promotion

doi:10.15541/jim20250433

Abstract

Abstract: Bone defects caused by trauma, infection, or osteoporosis pose significant clinical challenges. Developing bioactive materials to effectively promote bone regeneration is particularly important. However, osteogenesis is a complex process influenced by multiple factors. Existing bone biomaterials only focus on the effects of limited factors, leading to an urgent need to develop novel composite materials that can synergistically promote osteogenesis. In this study, mesoporous bioactive glass (MBG) was prepared via sol-gel method, and puerarin (Pue)-loaded MBG composites (Pue/MBG) were constructed through physical adsorption. The results show that the prepared MBG exhibits high specific surface area and ordered mesoporous structure, successfully achieving Pue loading and sustained release. In vitro experiments demonstrate that Pue/MBG composites effectively promote the proliferation of mouse embryonic osteoblast precursor cells and bone mesenchymal stem cells, while enhancing their osteogenic differentiation capabilities. This is evidenced by increased early-stage alkaline phosphatase activity and enhanced late-stage mineralization nodule formation, showing synergistic effect of Pue and MBG. In conclusion, this study successfully develops an efficient bone-repair composite material based on the synergistic effect of Pue and MBG, exhibiting excellent osteogenic capacity and promising applications in bone tissue engineering.

Key words: mesoporous bioactive glass, puerarin, osteogenic differentiation, sustained-release, biocompatibility

CLC Number:

R318.08

XU Ming, WANG Yuanfei, WU Tong. Puerarin/Mesoporous Bioactive Glass Composites: Preparation and In Vitro Synergistic Osteogenic-promotion[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250433.

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