Journal of Inorganic Materials ›› 2020, Vol. 35 ›› Issue (2): 173-178.DOI: 10.15541/jim20190127

Special Issue: 生物材料论文精选

• RESEARCH PAPER • Previous Articles     Next Articles

hBMP-2 Contained Composite Coatings on Titanium Mesh Surface: Preparation and hBMP-2 Release

FU Ya-Kang1,WENG Jie2,LIU Yao-Wen3,ZHANG Ke-Hong1   

  1. 1. Ya’an Polytechnic College, Ya’an 625000, China
    2. Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
    3. School of food, Sichuan Agricultural University, Ya’an 625014, China
  • Received:2019-03-25 Revised:2019-05-04 Published:2020-02-20 Online:2019-05-29
  • Supported by:
    National Natural Science Foundation of China(51572228);Natural Science Foundation Project of Sichuan Provincial Education Department(16ZB0546);Natural Science Foundation Project of Ya' an Polytechnic College(2016yzk15)


Titanate nanofibers were prepared on titanium mesh by alkali-heat treatment, and calcium phosphate coating was fabricated on the porous titanate nanofibers by electrochemical deposition technology. Then hBMP-2 was introduced into the coating by different methods to improve its osteointegration and bioactivity. Three kinds of composite coatings modified by hBMP-2 were prepared (TmhB, TmHedhB and TmHhBed). Surface morphology, chemical composition, phase composition and hBMP-2 amounts and hBMP-2 release performance of the composite coatings were characterized by SEM, ATR-FTIR, XRD, and hBMP-2 ELISA kit, respectively. Results showed that all of the coatings display porous fiber structure, calcium phosphate phase in TmHedhB and TmHhBed samples was hydroxyapatite (HA), and bead-like HA particles formed on the surface of titanate nanofibers. Protein adsorption experiments showed that introduction of bead-like HA phase increased the hBMP-2 adsorption on the composite coatings, and composite coatings prepared by electrochemical co-deposition technique further enhanced hBMP-2 adsorption up to 886 ng/mg, which were supported hBMP-2 sustained release within 6-48 h.

Key words: titanium, alkali-heat treatment, electrochemical deposition, hydroxyapatite, composite coating, hBMP-2

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