Journal of Inorganic Materials ›› 2019, Vol. 34 ›› Issue (4): 444-454.DOI: 10.15541/jim20180466

Special Issue: 优秀作者论文集锦 优秀作者作品欣赏(六)

• RESEARCH LETTERS • Previous Articles     Next Articles

Zirconia Incorporation in 3D Printed β-Ca2SiO4 Scaffolds on Their Physicochemical and Biological Property

Sheng-Yang FU1,Bin YU2,Hui-Feng DING2,3(),Guo-Dong SHI2,Yu-Fang ZHU1()   

  1. 1. School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
    2. Department of Orthopedics, Shanghai Public Health Clinical Center, Shanghai Medical School, Fudan University, Shanghai 200032, China
    3. Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China
  • Received:2018-10-06 Published:2019-04-20 Online:2019-04-15
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  • Supported by:
    National Natural Science Foundation of China(51872185);The Science and Technology Commission of Shanghai Municipality(17060502400);The State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University(LK1616);Academic Leaders Training Program of Pudong Health Bureau of Shanghai(PWRd2017-03);Science and Technology Development Fund of Shanghai Pudong New Area(PKJ2015-Y37);"Pu Jing" Training Program of Shanghai Pudong hospital(PJ201503)


3D printed bioceramics derived from preceramic polymers are of great interest in bone tissue engineering due to their simplified fabrication processes. In this study, three-dimensional (3D) porous β-Ca2SiO4 scaffolds incorporated with ZrO2 were fabricated from silicone resin loaded with active CaCO3 and inert ZrO2 fillers by 3D printing. The fabricated scaffolds possessed uniform interconnected macropores with a high porosity (> 67%). The results showed that the increase of ZrO2 incorporation significantly enhanced the compressive strength, and stimulated cell proliferation and differentiation of osteoblasts. Importantly, the in vivo results indicated that the ZrO2-incorporated β-Ca2SiO4 scaffolds improved osteogenic capacity compared to pure β-Ca2SiO4 scaffolds. Taken together, the ZrO2-incorporated β-Ca2SiO4 scaffolds fabricated by combining polymer-derived strategy with 3D printing could be a promising candidate for bone tissue engineering.

Key words: β-Ca2SiO4, ZrO2, polymer-derived, 3D printing, bone tissue engineering

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